Tag: "beta" at biology news
Sickle cell disease corrected in human models using stem cell-based gene therapy
...globin gene and small interfering RNA specific for beta
S-globin, the globin mutant chain that causes sickle cell disease. "An innovative and sophisticated approach was needed to genetically engineer hematopoietic stem cells using a practical and clinically applicable process. The transferred gene must n...
Researchers discover how a high-fat diet causes type 2 diabetes
...o type 2 diabetes due to failure of the pancreatic beta
cells. The experiments point to a mechanistic explanation for why failing pancreatic beta
cells don't sense glucose properly and how that can lead to impaired insulin production, said Jamey ...
Brain plays key role in diabetes therapy
...ith diabetes due to a lack of so-called pancreatic beta
cells, which normally secrete insulin. The rats' condition mimics type I, or juvenile, diabetes, a form of the disease that begins in childhood most often due to autoimmune destruction of cells in the pancreas, which leave the organ unable to produce...
Study links Alzheimer's disease to abnormal cell division
...ght on the theory that the accumulation of amyloid beta
in the brain causes the neuron death in AD. Becau.... However, tiny clumps made up of several amyloid beta
molecules (called micro-molecular aggregates) form before the plaques and may trigger the disease. ...
Common molecular 'signature' identified in solid tumors
...noblastoma-1 (RB1) and transforming growth factor, beta
receptor 2 (TGFBR2). Croce predicts that miRNAs themselves may one day be used as treatments. "If we can replace miRNAs that are lost and block those that are overly abundant, then maybe we can prevent some of the very earliest changes that happen i...
New survey sheds light on MS Therapy
...n choosing a disease-modifying therapy, interferon beta
medication is the top recommendation among survey ...ology (AAN) panel, which observed that interferon beta
therapies have the strongest and most consistent evidence of effectiveness, and that high dose, high...
JCI table of contents, February 16, 2006
...are insulin-producing cells of the pancreas called beta
cells. Although beta
cells are renewed during adult life, during insulin resistant states the beta
cells become hyperplas...
Astronomer announces shortlist of stellar candidates for habitable worlds
...nbull's top candidate star for such radio scans is beta
CVn, a sun-like star about 26 light-years away in the constellation Canes Venatici (the Hound Dogs). (One light-year is about 5.9 trillion miles). Astronomers have been using currently available technology to search the star for accompanying planets ...
JCI table of contents, February 23, 2006
... that deposits of the small protein called amyloid beta
(Abeta) contribute to AD-associated memory deficits. In a new study appearing online on February 23 in advance of print publication in the March issue of the Journal of Clinical Investigation, Kelly Bales and colleagues at Eli Lilly in Indianapolis, ...
HPV subtype associated with squamous cell skin cancers
...ction with human papillomavirus (HPV) types called beta
HPVs may be associated with an increased risk of d...epithelial cancers such as cervical cancer. Genus beta
HPVs, which includes HPV types 5 and 8, have been detected in skin tumors, and previous studies sugg...
New evidence suggests statins could prove useful in treating MS
...oved to treat multiple sclerosis. Copaxone and the beta
interferons are used to treat relapsing-remitting ...2004 due to severe toxicity in patients also given beta
interferon, though the Food and Drug Administration is now reviewing the drug, for possible reintrod...
New research shows Pin1 enzyme is key in preventing onset of Alzheimer's disease
...P (amyloid precursor protein) cleavage and amyloid beta
production, thereby preventing the formation of pl...P is broken into fragments of two types of amyloid beta
peptides Abeta40 and Abeta42, with Abeta42 being extremely toxic. Unlike the segments in the normal...
Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice
...he pancreas' ability to produce insulin, new islet beta
cells must be provided, either by transplanting ce...ic patient's own cells. Second, to protect the new beta
cells, no matter what their origin, it is necessary to repair the breakdown in immunological toleran...
Efforts to replicate controversial diabetes therapy bring partial success
...e unable to find any evidence of insulin-producing beta
cells derived from donated spleen cells, initially.... "We saw no evidence, however, of spleen-derived beta
cells in the pancreas, despite using very sensitive tests." While the results provide a boost for ef...
Researchers reverse juvenile diabetes in animal model; Clinical trial FDA approved
...ructive effect of T cells on the insulin-producing beta
cells of the pancreas, a process that is known to ... T cells as they travel to the pancreas to destroy beta
cells. "We did this in mice, giving them six injections over the course of several weeks. The injec...
'Bad' enzymes may wear white hats after stroke
...py with tPA," she said. "I also did some work with beta
amyloid, the protein implicated in Alzheimer's disease. It seems that beta
amyloid might increase levels of MMP-9 where MMPs would harm rather than help, and statins might hel...
16-Year follow-up study reinforces Betaseron long-term efficacy, safety and tolerability in MS
... Berlex announced today that Betaseron (interferon beta
1b) remained consistently safe, effective and well tolerated over the long term, according to results of the Betaseron 16-Year Long-Term Follow-up (16-Year LTF) Study presented at the 58th Annual Meeting of the American Academy of Neurology. This is ...
Blood pressure medication may revolutionize treatment of Marfan syndrome
...ecently discovered that transforming growth factor beta
-- not simply a defect in a structural protein -- ...buted to an increase in transforming growth factor beta
signaling in a variety of tissues, including the lungs, aorta and mitral valve. The next logical ste...
LIAI scientists make major finding on potential cure for type 1 diabetes
...olerate, rather than attack, the insulin-producing beta
cells of the pancreas. By injecting the anti-CD3 ...ms the immune system and lessens the attack on the beta
cells, along with a piece of the nasal proinsulin peptide, which acts like a vaccine and induces a s...
Joslin-led study reveals findings on how insulin-producing beta cells grow and function
...sively that two receptors in the insulin-producing beta
cell do not affect developmental growth, refuting ...ts to isolate the growth factors that do stimulate beta
cell growth and understand the defects in insulin production and secretion that cause diabetes. The...
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