Tag: "beta" at biology news
International support for Swedish stem cell research
...yonic stem cells to develop into insulin-producing beta
cells for transplantation into people with diabete...he right path to being fully developed functioning beta
cells. Dr. Henrik Semb from Lund University have already discovered that human embryonic stem ...
Scientists find gene in obese mice that increases type 2 diabetes
...e, which it does by growing more insulin-producing beta
cells or by ramping up insulin secretion. The Wisc...al for constructing the walls of blood vessels.The beta
cells of the pancreas, which are the critical insulin producing cells of the organ, are found cluste...
Ghrelin: A player in diabetes but not obesity?
...ereby increasing the sensitivity of the pancreatic beta
cell (the cell in the pancreas which produces insu...h this process, you increase ATP production by the beta
cell, you may in the long-term get oxidative stress which could eventually destroy the beta
UCSF Institute for Regeneration Medicine receives gift from Dolbys
...sts working to create insulin-producing pancreatic beta
cells to treat diabetes will be located in labs near one another, in so-called clusters. But they also will likely be based near a cluster of scientists working to create neurons to treat such brain diseases as Parkinson's disease, because stem cells...
OHSU researcher develops first animal model to treat devasting head and neck cancers
... lack expression of the transforming growth factor beta
receptor II (TGFbRII) in epithelial cells of the oral cavity. By then introducing activating mutations in either the H-ras or K-ras (two different isoforms of the Ras GTPase), the researchers were able to induce invasive HNSCC with 100 percent incide...
Modeling head and neck cancers
... lack expression of the transforming growth factor beta
receptor II (TGFbRII) in epithelial cells of the oral cavity. By then introducing activating mutations in either H-ras or K-ras (two different isoforms of the Ras GTPase), the researchers were able to induce invasive HNSCC with 100% incidence. The T...
New study reveals signaling pathways required for expansion of pancreas stem cells
... destruction of insulin-producing pancreatic islet beta
cells by the body's immune system. Islet beta
cells are spread throughout the pancreas and are made up of two types of cells: alpha cells, which m...
Other highlights in the May 17 JNCI
...amined the effects of medications epoetin alfa and beta
and darbepoetin alfa. They observed that epoetin and darbepoetin reduced the need for red blood cell transfusions and improved hematologic response. But use of the drugs with thrombogenic chemotherapy increased the risk of thrombo-embolic events, w...
Location, location, location: Transcriptional activity and nuclear position
...g the nuclear position and expression level of the beta
globin locus during various stages of erythropoiesis, the researchers found that beta
globin expression begins at the nuclear periphery, and as red blood cells mature, the beta
NIH panel urges more informed approach to multivitamin/mineral use for chronic disease prevention
...ts. Conversely, it found no evidence to recommend beta
carotene supplements, a form of vitamin A, for the general population, and strong evidence to caution smokers against taking them. Specifically, beta-carotene was linked to an increase in lung cancer among smokers who took the vitamin regularly. In ...
JCI table of contents, May 18, 2006
...DITOR'S PICK A non-invasive method for measuring beta
cell mass during diabetes Diabetes results from a reduction in the number of islet beta
cells in the pancreas, which leads to insufficient insulin secretion and high blood glucose levels (...
Research reveals control of potent immune regulator
...vity. It also looked at transforming growth factor beta
(TGFb), a substance also made by NK cells that lowers IFNg production. The research, by investigators with the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, found that th...
Gene therapy prevents the onset of diabetic symptoms in mice
...interleukin-10 (IL-10), into the insulin-producing beta
cells of non-obese diabetic (NOD) mice. Following gene delivery, expression of IL-4 in beta
cells prevented the onset of hyperglycemia in NOD mice, whereas beta
cell expression of IL-10 accele...
New treatment option breaks Leukemia's resistance to chemotherapy, radiation therapy
...particle therapy is much more potent than targeted beta
particle therapy or external radiation therapy," said Friesen. Low doses of alpha particles cause a prompt and complete cell kill in sensitive and resistant tumor cells, researchers discovered. "Our work considerably expands therapeutic options for t...
Researchers identify protein associated with severe preeclampsia
...nto.) A co-receptor for transforming growth factor beta
family proteins, endoglin is expressed on endothelial cells lining the blood vessels, and thereby plays an important role in maintaining the health and integrity of the vascular system. "Our further investigations revealed that the extracellular regi...
Gardenia fruit compound starting point for diabetes therapy
... causes of disease in insulin-producing pancreatic beta
cells. Insulin controls blood levels of glucose, t...sent a lead compound for agents aimed at improving beta
cell function in type 2 diabetes." Study coauthor Chen-Yu Zhang's familiarity with traditional Chine...
Increased sensitivity to nerve signals keeps diabetes at bay
... which the pancreas cells that produce insulin, or beta
cells, lack so-called M3 muscarinic acetylcholine ... genetically altered to harbor an excess number of beta
cell M3 receptors show the opposite: a profound increase in glucose tolerance and insulin release, t...
A sweet solution for Alzheimer's disease?
...er's disease has been that some compounds--such as beta
secretase inhibitors--cannot enter the brain easily, St George-Hyslop explained. Scyllo-inositol, on the other hand, readily passes through the blood-brain barrier where it is made available to the central nervous system. Even if scyllo-inositol does...
Teasing out tissue from blood
...rom brain and liver cells to the insulin-producing beta
islet cells of the pancreas. The idea is to revert a patient's blood cells to the stem cell stage and then chemically nudge them to re-specialise into particular tissue types that can be implanted to heal damaged tissue. A huge advantage over using ...
Bacteria, beware: New finding about E coli could block infections, lead to better treatments
...of adrenergic antagonists, drugs such as alpha and beta
blockers, to disrupt the receptor's sensing ability. They found that phentolamine binds to the QseC receptor and occupies the pocket that the receptor would use to recognize the host epinephrine and norepinephrine signals thus blocking the QseC rece...
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