Mutation in tumor suppressor gene causes pancreatic islet cells to reproduce
...lains Hua. In type I diabetes, the loss of islet beta cells is the leading reason why a sufficient amoun...ising new strategies to increase insulin-secreting beta cells and treating diabetes," notes Hua. "We did not expect the connection between a study about a...UF study sheds light on cystic fibrosis-related diabetes
...o eventually you get loss of the insulin-producing beta cells," said Michael Stalvey, M.D., an assistant p...ence to suggest there is an inherent difference in beta cell function." Cystic fibrosis patients suffer recurrent episodes of infection and inflammation t...Case Western Reserve University researchers find protein associated with brain cell death
...l surface complex to detect and respond to amyloid beta fibrils," the researchers write. "These receptor elements act in concert to stimulate intercellular signaling cascades as well as initiate a novel type of phagocytosis (cell death) in microglia." "Vav has been found to be the key regulatory eleme...Preclinical study shows chronic stress agitates ovarian cancer; reducing stress slows tumor growth
...f stress on tumor growth. The researchers used the beta blocker because the same hormone receptors, called beta adrenergic receptors, are found in the heart and normally work to maintain blood flow. "The concept ...JCI table of contents: August 1, 2006
... in which the body's own immune system attacks the beta cells of the pancreas, destroying or damaging them...shutting down the autoreactive T cells that attack beta islet cells is one therapeutic approach that researchers have been investigating. A molecule named c......named beta-thalassemia, which occurs when a mutant beta hemoglobin gene results in faulty production of he...ene, essentially creating an embryonic or juvenile beta hemoglobin gene that could make hemoglobin normally during adult life. ...Researchers devise new tools to help pinpoint treatments for heart failure
...ther cardiovascular diseases. The effectiveness of beta blockers has highlighted the need to better understand the system of biochemical signaling within heart cells. For example, the clinical observations and experimental findings of many scientists suggest that increasing the strength of heart cells c...ACS News Service Weekly PressPac -- August 2, 2006
...mptoms, but would inhibit the formation of amyloid beta -- the abnormal brain protein implicated in AD. ...n screening large numbers of compounds for amyloid beta inhibitors. They also describe its use in isolating new inhibitors. ARTICLE #4 "A High Throughput ...Defense peptide found in primates may block some human HIV transmissions
...research around the world has focused on alpha and beta defensins, the two types that humans still make. Cole studies theta-defensins called retrocyclins, which are no longer made by humans or advanced primates such as chimpanzees. However, theta-defensins are more active against HIV-1 than the other two ...New research points toward mechanism of age-onset toxicity of Alzheimer's protein
...itute shows that aging is what's critical. Harmful beta amyloid aggregates accumulate when aging impedes t... disease, on the other hand, are unable to control beta amyloid accumulation. For years, scientists have scrambled to find out why. To answer this vexing...Brain enzyme treatment relieves memory lapse in Alzheimer's mice
...therapies have almost exclusively targeted amyloid beta (A), the protein responsible for the "amyloid plaq...Shelanski of Columbia University. "While amyloid beta is certainly a key player in Alzheimer's disease--and efforts to reduce it remain a worthy goal--our...UCLA/LSU study details nutritional value of salad
...lic acid, vitamins C and E, lycopene and alpha and beta carotene in the bloodstream. Published in the September edition of the peer-reviewed Journal of the American Dietetic Association, the study also suggests that each serving of salad consumed correlates with a 165 percent higher likelihood of meeti...Molecules in blood foretell development of preeclampsia
...ly, a molecule known as transforming growth factor beta (TGF beta) binds to endoglin, and this binding is ...Dr. Levine added, so that more VEGF, PlGF, and TGF beta would be available for the blood vessels that need them. One company has developed the means to pro...Protein folding: Building a strong foundation
...that folds into a sandwich-like structure called a beta sheet, which is a common fold in nature that consists of two beta-sheets of amino-acid strands meshed together. "In folding study the right combination of expertise in computational and experimental approaches is vital for success," Ma said. "Our c...Slow brain waves play key role in coordinating complex activity
... second), alpha (8-13 oscillations per second) and beta (14-30 oscillations per second) to the most rapid firings in the human brain - gamma oscillations (30-60 oscillations per second). Because slow firings are detected when the brain is least active, while rapid firings accompany activity, neuroscientis...ACS News Service Weekly PressPac -- Sept. 20, 2006
...leagues exposed cell cultures of insulin-producing beta cells to methylmercury. They used concentrations ...ells. Liu and colleagues now have added pancreatic beta cells to that list. "Altogether, our data clearly indicate that methylmercury-induced oxidative str...ACS News Service Weekly PressPac -- Oct. 4, 2006
...urotransmitter degradation and reeducating amyloid beta aggregation, thereby simultaneously treating both the symptoms and progression of Alzheimer's disease." ARTICLE #1 FOR IMMEDIATE RELEASE "A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology" DOWNLOAD PDF htt...JCI table of contents: Oct. 12, 2006
... via its physical association with thyroid hormone beta receptor (TRbeta), which binds thyroid hormone (T3...tion of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression AUTHOR CONTACT: Sheue-yann Cheng National Cancer Institute, B...Molecular 'signature' protects cells from viruses
...or example, they then produce what is known as the beta interferon, thereby activating specific killer cells. They also initiate the cell's suicide programme apoptosis. The viruses cannot then continue to breed.' Up to now it was not known how cells distinguish their own RNA from that of the 'enemy'. T...Naturally occurring enzyme can break down key part of Alzheimer's plaques
...eady knew of three enzymes that break down amyloid beta (Abeta), a protein fragment that clumps together with itself to form the fibrils," says Jin-Moo Lee, M.D., Ph.D., assistant professor of neurology. "But the thinking up until now had been that Abeta might be clumping together so tightly that the fibr...