The power of one: A simpler, cheaper method for cell fusion
...ng hybrid, called a hybridoma. By manipulating the beta cells prior to fusion, scientists can create thousands of different hybridomas that produce antibodies effective against different viruses and diseases like cancer. Lu's research regarding the development and use of this technology was published on...Research yields new insights into the cause of diabetes
...e normally because they have few insulin-producing beta cells in their pancreas and the remaining cells do...e lack of this enzyme blocked the proliferation of beta cells, hampered the normal functioning of beta cells, and also kept beta cells from clustering into ...Beyond the book: Software automates access to brain atlases
...es. The software, now available in an experimental beta version for free download, is a robust and user-friendly interface that works on all the most popular computer operating systems. "Brain atlases are basic tools for researchers in neural science," says Gully A.P.C. Burns, a specialist in neuroinform...PLoS ONE is launched by the Public Library of Science
...technology will no doubt hold some surprises. The beta version5 of PLoS ONE that is launched today is a work-in-progress. It is presented in beta because PLoS wishes the community to help shape PLoS ONE, and the underlying publishing platform, in...Genetic mechanism helps explain chronic pain disorders
...o treatment with pharmacological agents that block beta 2- and beta 3-adrenergic receptors, which mediate COMT-dependent pain signaling, or that control mRNA secondary ...Genetic mutation alters response to heart failure drugs
The group of drugs known as beta blockers help slow nerve impulses traveling throug...ergic receptors present in cardiac cells. As such, beta blockers have become a mainstay of the treatment regimen for chronic heart failure. However, doctors...JCI table of contents: January 2, 2007
...eart failure drugs The group of drugs known as beta blockers help slow nerve impulses traveling throug...ergic receptors present in cardiac cells. As such, beta blockers have become a mainstay of the treatment regimen for chronic heart failure. However, doctors...JDRF forms partnership with MacroGenics
... autoimmune attack that destroys insulin-producing beta cells. In addition, JDRF will also fund research ...f new onset type 1 diabetes. Because it preserves beta cell function in newly diagnosed patients, anti-CD3 treatment has the potential to decrease insulin ...Genetically altered cells may help artificial skin fight infection
... produce higher levels of a protein known as human beta defensin 4 (HBD4) killed more bacteria than normal skin cells. HBD4 is one in a class of proteins that exist throughout the body as part of its natural defense system. Researchers have only recently begun targeting these tiny molecules as a way to...Genetic variation may reduce Alzheimer's risk
... but not yet scheduled for print, also showed that beta amyloid peptide, a major culprit in Alzheimer's, h...n the human brain to find those that interact with beta amyloid peptide. This approach uses a virus to infect a bacterium so the bacterium will copy the vir...Scientists find new genetic clue to cause of Alzheimer's disease
...ecursor protein, or APP, is processed into amyloid beta protein fragments that make up plaques in the brai...nts that demonstrate SORL1's role in production of beta amyloid fragments. Examining blood cells from people with and without Alzheimer's, the researchers...New gene uncovered for late-onset Alzheimer's
...that increases the production of the toxic amyloid beta (A]) peptides in the brain resulting in Alzheimer'...ocessing and the accumulation of its toxic amyloid beta (A) peptide derivative cause Alzheimer's, so we hypothesized that other genes associated with APP re......ocessing and the accumulation of its toxic amyloid beta (A) peptide derivative cause Alzheimer's, so we hypothesized that other genes associated with APP regulation might also cause the disease." SORL1 governs the distribution of APP inside nerve cells of the brain. When working properly, the SO...Cells passed from mother to child during pregnancy live on and make insulin
...eas and are functioning there as insulin-producing beta cells. The study, initially undertaken in the beli...e researchers found a small number of female islet beta cells in male pancreatic tissue (procured from autopsies) that produced insulin. Microchimerism is t...Joslin-led study uncovers role of appetite hormone MCH in insulin production
...e, plays a role in the growth of insulin-producing beta cells and the secretion of insulin. This finding h...that stimulate the production of insulin-producing beta cells in the pancreas. This latest research, conducted with researchers at Beth Israel Deaconess Med...... worm gene named unc-70 that makes a protein named beta spectrin. Humans have four beta spectrin genes, and mutations in one of them was identified previously as the cause of SCA5, a neuro...Taking heart failure to the MAT1
...sm. In fact, two forms of PGC-1 exist alpha and beta both of which have been reported by other groups ...y. Finding an essential partner of PGC-1 alpha and beta that enables them to switch genes on via these receptors should be helpful in that kind of work."...Targeting the adrenal gland could be key strategy against heart failure, Jefferson scientists show
...king a bad situation worse. The typical treatment beta blockers inhibit the beta adrenergic receptors on the heart, blocking the hormones that force the heart to work overtime. D...Unique tomatoes tops in disease-fighting antioxidants
...lycopene, and a tomato variety chosen for its rich beta carotene content. The tomatoes were grown at an ...ther featured sauce made from the tomatoes high in beta carotene. The participants were asked to avoid tomato and beta carotene-rich foods for 13 days befor...Joslin researchers discover a surprising culprit in the search for causes of diabetic birth defects
...lut2 transporter is expressed on insulin-producing beta cells of the pancreas and in the liver, the tissue... pancreas where the high glucose level signals the beta cells to release insulin, and in the liver, where it signals the liver to store the glucose. In a no...