DNA sequence controls expression of gene involved in cancer
...the bcl-2 gene that controls its expression may be big news for cancer therapy. Several drugs that reduce the amount of bcl-2 present in the cell are already used in chemotherapy to induce apoptosis and overcome drug resistance in cancer cells....Daphne Koller named MacArthur Fellow
...ime to think about it." The news always comes as a big surprise, since the selection process is confidential and no notification is given to fellows until final selections are made. Koller's research tackles questions of how complex information with high levels of uncertainty can be approached using ...Muscling in on a deadly cancer
...a number of cancers involve stem cells. So "it's a big deal for a [mature or nearly mature muscle] cell not be proliferating and then all of a sudden to be able to proliferate" to form tumors, Capecchi adds. Keller says other researchers previously found that maturing skeletal muscle...The long road to a promising malaria vaccine started at NYU School of Medicine
...the vaccine's protection will be, but it is a very big step forward." The vaccine, designated RTS.S/AS02A, contains a large portion of a protein called circumsporozoite (CS) protein, which coats malaria parasites that invade the liver. This protein, which the Nussenzweigs first isolated from pa...Scientists identify new cause of obesity
...he network of signals that controls appetite got a big boost in 1994 with the discovery of leptin. This protein circulates in the body at concentrations proportional to the mass of body fat. It initiates the signaling pathway that determines whether or not MC4R will trigger the body's urge to eat. MC4R i...To save dolphin's dorsal fin experts combine medical technology and teamwork
...issue. "Liko's story is a story of medicine with a big heart," said Rae Stone, D.V.M., a Dolphin Quest veterinarian and co-owner. "It shows extraordinary voluntary cooperation across several human medical and veterinary disciplines that has involved numerous experts with cutting-edge technology and speci...Study in Royal Society journal on how relationship status influences sex ratios
...ng. Amazingly, we can in this way prove one of the big open questions in entanglement theory, the "hashing inequality".Contact: Dr Andreas Winter, Department of Computer Science, University of Bristol, Merchant Ventures Building, Woodland Road, BRISTOL, BS8 1UB Phase mixing of...Large-scale forces shape local ocean life, global study shows
... led to another key finding: Latitude also plays a big role in local species richness. At the poles, partly due to the harsh environment and glacial scouring, there are fewer species. But moving closer to the equator, the number of species increases. While this is a long-held and widely acc...Molecule that helps DNA replicate may make good target for cancer therapy
...A strands where it can attach and go to work. "The big question was, How is polymerase alpha recruited to the first site?" said Bielinsky. "We found that Mcm10 brings the DNA polymerase alpha complex to the chromosomal sites where replication originates. It does this by attaching to the protein that keep...Darwin's greatest challenge tackled: the mystery of eye evolution
...lutionary origin. We had finally solved one of the big mysteries in human eye evolution."...Research to explore revolutionary gene sequencing: Threading the molecular needle
...olecular rings," explained Lindsay. "They are just big enough to slide a strand of DNA through. Conveniently, Mother Nature also makes them with neat little reactive groups on the side, so you do chemistry with them." Through the reactive groups on the side of the rings, Lindsay's technology p...Findings challenge Darwinian theory
Did that lobster on your dinner plate inherit its big crusher clawor did it evolve through need, without the help of genes? Genetics aren't the only triggers for the traits a species develops, according to findings from a University of Alberta professor. The research challenges the classical Darwinian...Bristol scientists find key to unlock body's own cancer defence
...rper, added: "After two years of hard work it is a big step to show that this protein works in real cancers. We hope to be able to take this forward in the next few years to work out how to treat patients with cancer, eye disease and other conditions where this protein is important."......hese organisms lived 600 million years ago before big animals. This the very first moment of animal evolution preserved in the fossil record." The research, "Animal Embryos from the terminal Neoproterozoic Doushantuo Formation: How did they hatch?," written by Xiao of Virginia Tech's College of Science,...Powerful 'toolkit' developed for functional profiling of yeast genes
...e. "We think our numbers are sufficient to get the big picture of how genes interact, and the technique has better potential to scale to the whole genome than other techniques." In one set of experiments, the new technique identified 116 genes that were synthetic lethal with a gene called cin8 a...Declining fish supply linked to wildlife consumption in West Africa, Science study reports
...ped together under the label "bushmeat." Primates, big cats, elephants, antelope, porcupines, giant snails, tiny songbirds and most any other wild land animal from the tropics that hunters kill and sell or consume themselves can be considered bushmeat. The multi-billion dollar bushmeat industry is a ke...Extinction in ocean's mud presages key ecological changes
...the bottom of the ocean, but also because it has a big impact on the rest of the marine ecosystem." In the mud and sediments that have accumulated during many thousands of years at the bottom of the world's oceans lives an astonishing array of animals - such as crabs, clams, sea urchins, brittlestars ...Order of species loss has important biodiversity consequences, grassland study reveals
...sprinkled around, but they can still be exerting a big effect on the way the system works. Zavaleta likens the ecosystem benefits of retaining rare species to the role of a child plugging a dike with his thumb. "It's a small difference that can have huge consequences," she said. "Most ecologists w...Building a tree of life needs less 'wood'
...rated quite easily. But existing databases contain big gaps, because some organisms have been studied ver... databases. They found that even though there were big gaps in the data, with many groups of organisms represented by a single sequence, it was still possi...Endurance running may be key to evolution of human body form
...vores for access to the protein needed to grow the big brains that we enjoy today." Protein and fat derived from prey are excellent food for growing the bodies and brains of predators; Lieberman suggests running may have fueled growth of the human brain by relaxing constraints on human acquisition of ...