Counting heads or measuring space?
...escent bacterium Vibrio fischeri, which only shows bioluminescence from a certain cell density. Therefore, the release of signal molecules was first understood as a strategy to determine the cell density (quorum sensing). With its cooperative approach, however, quorum sensing does not provide a stable survival strat...Keeping the body in sync -- the stability of cellular clocks
...y environment? Using mouse fibroblast circadian bioluminescence recordings from the Schibler Lab at the University...w the stability of the oscillator directly affects bioluminescence recordings, explains Felix Naef, a systems biology professor at EPFL and the Swiss Institute for Exp......e 659), was implicated in FASPS. By monitoring the bioluminescence cycles of cell lines, the researchers demonstrated that mutation of Serine 659 causes a shortening of the luminescence period and recapitulates the FASPS phenotype. The researchers determined that the mutated form of Serine 659, which does not get ph...Deep sea explorer and marine conservationist wins MacArthur Fellowship
...ostly methods of hand sampling." A specialist in bioluminescence (the light chemically produced by many ocean organ...ng HIDEX, a bathyphotometer that measures how much bioluminescence there is in the oceans and LoLAR, a very sensitive deep-sea light meter. Most recently, Widder helpe...SNM names Sanjiv Sam Gambhir as recipient of 2006 Paul C. Aebersold Award
...logies such as micro positron emission tomography, bioluminescence optical imaging with a charge coupled-device camera, fluorescence optical imaging and micro computerized axial tomography for investigation with small animal models. He and his laboratory researchers have developed methods to image gene/cell therapy ...Penn clinical chemist wins prestigious Ullman Award
... first is his application of chemiluminescence and bioluminescence to clinical analysis. He was instrumental in the development of two of the three major chemiluminescent technologies currently used in routine testing, including an enhanced luminescence system for peroxidase labels and the 1,2-dioxetane substrate, n...Deep-sea exploration beneath Katrina's wake
...-in-the-Sea beyond basic observation is to use the bioluminescence lure and other techniques to learn how animals use the light they produce. Based in large part on the success of last year's expedition, Widder has been awarded a $500,000 National Science Foundation grant to build a more advanced Eye-in-the-Sea in ...Firefly protein lets researchers monitor molecule linked to cancer
...chers can employ an instrument known as an in-vivo bioluminescence camera to take real-time measurements of light from luciferase in cell cultures and in cells within live animals. To use the firefly protein to monitor IKK, Gross altered cell lines to genetically fuse the luciferase protein to IKB (IKappaB), the pr...Deep-sea jelly uses glowing red lures to catch fish
...ess of producing their own light. Some jellies use bioluminescence as a defense-they glow when disturbed in order to ...y in the siphonophore's behavior. Jellies that use bioluminescence for self defense tend to have lights distributed all around their body, which flash brightly when di...Peripheral timekeeping: Mammalian cells outside the brain have their own circadian clocks
...rn University, Dr. David Welsh and colleagues used bioluminescence imaging to monitor circadian rhythms of clock gene expression from individual rat or mouse fibroblasts. Robust rhythms of single cells persisted without diminishing for at least 12 weeks in culture. Cells were partially synchronized by medium change ...