Tag: "biosynthesis" at biology news

32 new grants made for innovative technology R&D

...to enable simple, efficient genetic engineering of biosynthesis complexes to produce cyclic peptides for use as antifungal, antibacterial and anticancer drugs. Carbon Nanotechnologies, Inc. (Houston, Texas) "Free Standing" Single-Wall Carbon-Nanotube Fuel Cell ElectrodeDevelop a novel, free-standing single-...

JCI table of contents, December 1 2004

...ether specific bacterial genes are crucial for the biosynthesis of ganglioside-like structures and the induction o...e locus encoding genes known to be involved in LOS biosynthesis in Campylobacter jejuni strains associated and not associated with GBS. In the December 1 issue of t...

Cloned gene from sea animal may prove key in cancer drug development

...ignificant step forward inunderstanding bryostatin biosynthesis and eventually harnessing bry genes to produce bryostatins and derivatives inexpensively and in abundant quantities," the authors write in the paper, one of the first studies that describes such a cloning achievement from a marine symbiont organism. ...

EB and IUPS - Where cures of tomorrow can be seen in the science of today

...rs, lipid-protein interactions, and enzymes in the biosynthesis and tailoring of peptide natural products. American Society for Nutritional Sciences (ASNS) sessions cover diverse aspects of nutrition, such as dietary bioactive compounds and metabolism; carbohydrate and alcohol metabolism; nutrient-gene intera...

Protein tyrosine phosphatases to be topic of ASBMB-Merck Award lecture

... in his career, he was a leader in research on the biosynthesis and posttranslational processing of polypeptide hormones. He adopted the tools of molecular biology as they became available in the late 1970's, and his laboratory was among the first to use a synthetic oligonucleotide to identify and clone cDNAs enc...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

... of the mechanism activate many key genes of lipid biosynthesis involving the pathways of cholesterol and triglycerides; these genes directed the liver to manufacture more cholesterol, which it does in the form of very low-density lipoproteins. The investigators noted that in mice fed high-fat diets, the PCG-1bet...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

... certainly a "missing enzyme" from the pathway for biosynthesis of the iron scavenging agent mycobactin," recalls ...mycobactin are drug targets, because if mycobactin biosynthesis is stopped, the bacterium cannot acquire the iron that it needs for survival," explains Dr. Baker. "...

Whale bones and farm soil: Sequencing biodiversity

... predicted to be involved in DNA repair and in the biosynthesis of antibiotics. "Although only a limited number of pieces of the puzzle have been revealed through the many thousands of fragments of DNA from different organisms, they are sufficient to capture differences between the communities from genome sizes t...

Little microbe inside sea squirt makes big splash

...monstrated an important proof of principle for the biosynthesis of naturally occurring marine products."...

Marine sponge yields nanoscale secrets

...-fold more than man can produce, said Morse. "This biosynthesis is remarkable because this nanoscale precision can't be duplicated by man." Besides this remarkable precision, nature manages to produce silica at a low temperature, in an environmentally friendly way without the use of caustic chemicals, whereas man...

Researchers reveal basis for debilitating hereditary disease

...tations cause the enzyme to fail, disrupt the heme biosynthesis pathway and culminate in coproporphyrin accumulation," Raman said. Excess porphyrins are excreted in the feces and urine. As a result urine from patients suffering from coproporphyria turns red or purple when exposed to light. The CPO structure is ...

Important factors involved in the synthesis of starch in plants

... Spanish . The classic model for explaining the biosynthesis of starch in plant leaves has been seriously calle...e to date the accepted belief has been that starch biosynthesis is produced solely in the chloroplast, biologist Nora Alonso Casajs' PhD provides evidence to show t...

Novel protein complex enables survival in hostile environment

...le that M. jannaschii had this enzyme for cofactor biosynthesis and having it in advance gave the organism a selective advantage when oxygen, and consequently sulfite, appeared," Mukhopadhyay said. "Since we now know that methanogens had a way to handle sulfite toxicity, we could hypothesize that the rest of the...

CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts

...ndent filamentation in C. albicans and the capsule biosynthesis in C. neoformans. The authors go on to show that C...by providing bicarbonate substrates for fatty-acid biosynthesis and other cellular processes. In contrast, the CA enzyme is dispensible for the yeast's survival in ...

JCI Table of Contents, April 13, 2006

...s the beneficial effects of low-dose aspirin. PGE2 biosynthesis is catalyzed by the coordinate actions of COX enzymes and microsomal PGE synthase-1 (mPGES-1). In the effort to propose an alternative therapeutic option to COX-2 inhibitors, FitzGerald et al. showed that deletion of mPGES-1 suppressed PGE2 expressio...

The molecular post office inside the cell

... bacteria to humans. Particularly important during biosynthesis is sorting secretory and membrane proteins, which have to find the way to their final destination inside or outside the cell. Secretory proteins are those that later on leave the cell, like anti-bodies. Membrane proteins are proteins embedded into th...

Methane-belching bugs inspire a new theory of the origin of life on Earth

... natural gas. A detailed understanding of methane biosynthesis could lay the foundation for a new alternative energy source, by raising the possibility of cost-efficient conversion of renewable biomass into clean fuel. James G. Ferry is Stanley Person Professor of Biochemistry and Molecular Biology, and Christop...

Study points to genes responsible for malaria parasite's survival in attempts to eradicate it

...yclohydrolase gene, the first enzyme in the folate biosynthesis pathway. Downstream members of this pathway are targeted by several widely used antimalarials, and authors speculate that an amplification of the GTP cyclohydrolase enzyme facilitates parasite resistance to antifolate drugs. "I'm super excited about ...

UCI researcher named Pew Scholar

...r the award by UCI for her work in deciphering the biosynthesis of polyketides, a class of natural products derived from plants, fungi and bacteria that have been used extensively in drug development. Pew Scholars are chosen for excellence and innovation in their field through a highly competitive selection proce...

Key fat and cholesterol cell regulator identified, promising target

...nchpin for SREBPs control of cholesterol and lipid biosynthesis genes, which may provide a potential molecular Ach...e no longer able to activate cholesterol and lipid biosynthesis genes. To validate these findings in a physiological setting, the researchers turned to the microsco...

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