Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...athway. Constitutive activation of NF-κB to block apoptosis has been implicated in various types of cancer, but the molecular mechanisms involved are not well understood. Two separate research groups used a variety of sophisticated genomic techniques to examine mutations in hundreds of MM patient sa...Bursts of waves drive immune system 'soldiers' toward invaders
... metastasis, the finding may lead to strategies to block cancer growth. Similarly, faulty regulation of white blood cell movement plays a role in heart attack - another promising target for applying the new insights of the regulation of cell movement, the authors say. White blood cells, or neutrophils, ...Weizmann Institute scientists discover a control mechanism for metastasis
... the scientists examined the effects of drugs that block the growth factor receptors on the cell walls. In patients who received these drugs, the harmful 'plug' proteins had disappeared from the cancer cells. Prof. Yarden: 'The mechanism we identified is clinically important. It can predict the development...Inflammation may cause preterm labor and fetal deaths
...discovery led Han and her colleagues to attempt to block the inflammatory process by using synthetic TLR4 a...4 receptors but were given a synthetic compound to block the receptors inflammatory response. Within eighteen hours, inflammation was present in the TLR4 mic...Lost forest yields several new species
...st has been isolated from much of the Congo Forest block for at least 10,000 years and as a result contains some new interesting species, said WCS researcher Deo Kujirakwinja, one of surveys participants. There is a real need to protect this forest and carry out more research in the area. The Democratic ...Penn researchers discover how key protein stops inflammation
...ity, we may be able to create an artificial way to block the inflammatory response. In the laboratory of senior author Youhai Chen, PhD, Associate Professor of Pathology and Laboratory Medicine, Carmody and others searched for clues as to how Bcl-3 controls inflammation by examining how Bcl-3-deficient m...New mechanism links smoking to lung damage
...ing drugs or other mechanisms that can selectively block these unpaired channels offers a novel approach to disease prevention."...Multicenter study nets new lung tumor-suppressor gene
...rth Carolina have found that a particular gene can block key steps of the lung cancer process in mice. The researchers report in the journal Nature that LKB1 is not only a "tumor-suppressor" gene for non-small cell lung cancer in mice, it also may be more powerful than other, better-known suppressors. The ...Marijuana component opens the door for virus that causes Kaposi's sarcoma
...an take away that effect by using antagonists that block the two cannabinoid receptors, which adds evidence that THC is the culprit, Dr. Groopman said. Once a cell is infected, the presence of THC may also promote the cellular events that turn it cancerous, the researchers say. They found that THC also...Altering a protein makes mice less fearful
...the stage for investigating whether therapies that block these ion channels in humans might be effective in anxiety disorders," said Wemmie, who also is a physician and researcher at the Veterans Affairs (VA) Iowa City Health Care System. The UI team found that ASIC1a is concentrated in brain regions tha......will be to screen compounds that could potentially block the action of this gene and other genes identified...ists plan to screen compounds to find ones able to block specific processes they have identified in the anthrax microbe....Molecule blocks gene, sheds light on liver cancer
...al Center. They show that high levels of miR-21 block the PTEN gene, he explained. This, in turn, activates chemical pathways that enable cancer cells to proliferate, migrate and invade other tissues, all of which are features of tumor formation. Patel and his collaborators began the study by measuri...47th Interscience Conference on Antimicrobial Agents and Chemotherapy
...deadline is August 17, 2007. As the ICAAC housing block often sells out quickly and far in advance of the housing deadline, journalists are strongly encouraged to pre-register as early as possible. The press room will be open for registration from 12 noon to 5 p.m. on Sunday, September 16 and sessions...Discovery in plant virus may help prevent HIV and similar viruses
...hese types of viruses, such as HIV, because if you block them, then the viruses simply can't replicate." The retrovirus HIV and the pararetrovirus CaMV both use reverse transcription to recruit the host's proteins in order to reproduce and spread infection. Transcription in cells is the process in which ...New target for HIV/AIDS drugs and vaccine discovered
... might aid the discovery of suitable drugs able to block the activity of this smart protein. Quaranta added, An exciting possibility is the design of a vaccine including a mutated Nef protein unable to assist the virus in the control of its host. The research findings also raise another intriguing possib...Gene-transcription machinery seen poised for action, held in check until needed
...urrent study, experimental techniques were used to block the removal of ubiquitin in order to illuminate the importance of the removal step and detail the resulting effects. When ubiquitin cannot be removed from the histone, the first thing seen is that a particular enzyme normally recruited into the pro...Scratch no more: Gene for itch sensation discovered
...like this, a lot of substances have been made that block the activity of GRPR. So now researchers can study the effect of these agents on the itch sensation and possibly move that research to clinical applications fairly soon."...Researchers watch antibiotics, bacteria meet at atomic level
...e elongation complex adds a nucleotide (a building block of DNA or RNA) to the growing RNA chain. This loop must open again to allow the next cycle to happen. If something such as an antibiotic keeps the loop from closing, RNA polymerase can't properly function and stalls. This loop is a target for antib...Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
...ing the second or third week by certain cells that block the repair process. In earlier research on rats with cords that were completely severed, Kalderon was able to show that radiation therapy, similar to that used in cancer treatment, given localized at the lesion site during the third week followin......responds by making more of this enzyme. If we can block the tumour response, we should be able to successfully treat some tumours with vitamin D compounds, says Dr. Jones, whose research is supported by the Canadian Institutes of Health Research. Vitamin D deficiency has also been correlated with other...