Twist on chest pain drug improves heart attack outcome
...al after a heart attack is to return blood flow to blocked arteries as quickly as possible. But that sudden b...flow of the nutrient solution. After 30 minutes of blocked blood flow, the solution injections were started again, and continued for 45 minutes. The research...U of I scientist develops enzyme inhibitor that may slow cancer growth
...cavity into the mouse's liver, where the inhibitor blocked the BHMT-catalyzed reaction as we thought it would." Garrow believes BHMT inhibitors may work best in concert with other drugs. "In today's medicine, there's rarely one magic-bullet drug. We know that when you decrease the availability of methionin...Speeding discovery of the 'human cancer genome'
...ay a role in skin cancer's spread, the researchers blocked the protein in both mouse and human metastatic melanoma cells. Cancer cells without active Nedd9 lost their ability to invade. Similarly, primary melanomas, when made to express too much Nedd9, became invasive, identifying Nedd9 as a "bona fide melan...Bacteria, beware: New finding about E coli could block infections, lead to better treatments
...ed receptor in a strain of Escherichia coli can be blocked to avert infection, a finding that might aid in developing better therapies to treat bacterial infections resulting in food poisoning, diarrhea or plague. Researchers at UT Southwestern Medical Center are the first to identify the receptor, known as ...Researchers reverse Parkinson's symptoms in animal models
...ansport between the ER and the Golgi. Proteins are blocked from navigating this crucial route, and the cell dies. This isn't just a general toxic effect caused by any misfolded protein. It is specific to alpha-synuclein, the protein associated with Parkinson's Disease. "All this was done in yeast," says Gi...Study identifies new tumor suppressor
... University in Taiwan, and colleagues increased or blocked the expression of HLJ1 in lung carcinoma cells in the lab and examined the gene's expression in tumor and surrounding tissue cells of 71 patients with non-small-cell lung cancer. HLJ1 is a protein involved in a cell's defense mechanism against outsid...U. of Colorado team solves mystery of carcinogenic mothballs
...e enzymes from both nematodes and from humans were blocked after exposure to naphthalene, indicating a "comparable pharmacology" between worms and humans, said Xue. Understanding how carcinogenic compounds can trigger tumor growth is important for federal regulatory agencies that deal with human exposure to...New understanding of COX-1 and COX-2 enzymes could revise classification of pain meds
COX-1 and COX-2 enzymes may be blocked by pain medications such as Advil and Vioxx in a more complex manner than was previously understood, a Queen's University study has found. "The results of the study have potential implications for how we classify the commonly used anti-inflammatory a...Harvard Medical signs agreement with Merck to develop potential therapy for macular degeneration
...uscin, administration of the inhibitors completely blocked formation of the A2E lipofuscins, the most common components of lipofuscin found in the eye. "Our own work focuses on basic, mechanistic chemical approaches to understanding the biology of vision. Now that it is time to translate this work into the c...Acetaminophen safe to use after heart attack but doesn't protect the heart
...on as possible following a heart attack to get the blocked artery open and to save as many heart muscle cells as possible. Reperfusion therapy, which may use balloon angioplasty, surgery, or clot dissolving drugs, is used in about 40% of heart attack patients, and its use is becoming increasingly common, Gor...Unique dual target specificity of kinase inhibitor key for success against cancer
...lines. One compound, PI-103, uniquely and potently blocked the growth of glioma cells. The cellular activity of PI-103 was traced to its ability to cooperatively inhibit both the p110 subunit of PI3 kinase and a downstream molecule called mTOR that also plays a critical role in cell growth. Although both of ...Research uncovers signaling pathways related to brain-immune system links
...uglas showed in 2001 that another NK-1R antagonist blocked HIV replication within macrophages in cell culture. The hope is that aprepitant may show a similar protective effect in patients. "We postulate that blocking NK-1R may send signals to turn off the CCR5 receptor for HIV, closing the door to the virus,...Nanotechnology shows early promise to treat cardiovascular disease
...into micelles, Mogue tested them for how well they blocked LDL uptake. "We're employing the tools of nanotechnology specifically tailoring the structure of the molecule, changing groups on the ends of the chains and closely analyzing which forms of the particles bind to the different macrophage receptors," ...News tips from The Journal of Neuroscience
...d no effect on PPI, a 5-HT 1A receptor antagonist blocked the antihyperkinetic effect of amphetamine. There also was an amphetamine-induced increase in activity in prefrontal cortex as measured by c-Fos labeling. Although not quite an animal model of ADHD, the Adcyap1−/− mouse may help explain...Selectively blocking inflammatory signals may protect mice from MS
...suppressor of cytokine signaling 1, or SOCS1) that blocked the response of myelin-producing cells to interferon-gamma. Although transgenic mice with low levels of interferon-gamma showed no symptoms of nervous system damage, 18 out of 20 mice exposed to higher interferon levels developed difficulty walking, ...Neurons find their place in the developing nervous system with the help of a sticky molecule
... by their neuronal progeny that form layer 2/3 and blocked their ability to make MDGA1 protein. When Takeuchi and O'Leary examined the neocortex a few days later when the mice were born, they discovered that nearly all neurons containing the interfering RNA were stalled in aberrant deeper locations, indica...Inhibition of iron-metabolizing enzyme reduces tumor growth
...ere given specific pharmacological inhibitors that blocked heme oxygenase-1 activity showed a significant reduction in tumor growth without apparent side effects. "Considering that heme oxygenase-1 is overexpressed in human Kaposi's sarcoma lesions, the inhibition of intratumoral heme oxygenase-1 activity by...A broken stress response system can contribute to Gleevec resistance
...an enzyme (BCR-ABL) whose activity is specifically blocked by Gleevec treatment. The work reveals that loss of a gene known as Arf, which is frequently mutated in patients with ALL, but not CML, can cause some leukemias to resist Gleevec treatment. Patients with CML who are taking Gleevec readily go into...Single microRNA causes cancer in transgenic mouse
...We believe that miR 155 initiated the process that blocked further differentiation of these cells," says Costinean. Croce says the results are consistent with previous study findings. "We know that miRNAs often act just like oncogenes, in that they promote abnormal cell growth that leads to cancer. Others, ...Research provides clues to obesity's cause and hints of new approach for curbing appetite
...sions containing both leptin and high doses of CRP blocked the action of leptin. The mice continued feasting, getting even fatter, and were no longer protected against diabetes. Giving CRP alone affected neither food intake nor body weight. In a different experiment, the researchers found that when exposed ...