Genome of Clostridium botulinum reveals the background to world's deadliest toxin
...s the one real weapon in the genome of Clostridium botulinum and less than 2 kg the weight of two bags of suga...nown as Botox. The genome sequence shows that C. botulinum doesnt have subtle tools to evade our human defences or tricky methods of acquiring resistance to an...Botulism bug has few genome wrinkles
...s the one real weapon in the genome of Clostridium botulinum and less than 2 kg - the weight of two bags of sug...quence, reported in Genome Research, shows that C. botulinum doesn't have subtle tools to evade our human defences or tricky methods of acquiring resistance to a...Pioneering research into health benefits of beauty treatment
...arrying out a randomised trial involving injecting botulinum toxin into the bladders of women who have overacti...ency to pass water and sometimes incontinence. The botulinum toxin relaxes the bladder muscle so it cannot squeeze so hard, and so reduces the need to pass water...Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
...toxic substances known to scientists. One subtype, botulinum neurotoxin A, is a 100 billion times more potent t...ut extremely rare illness. There are seven related botulinum neurotoxins (A through G), although each acts differently and only four attack humans. The toxins ki......at occurs when spores of the bacterium Clostridium botulinum contaminate a wound, germinate, and produce botuli...putting the patient on a ventilator and giving him botulinum antitoxin. The patient made a full recovery. The team of doctors who treated the man, a team by l...Study reveals molecular basis of botulism toxin's deadly activity
...al basis of the remarkably strong interaction that botulinum toxins form with nerve cells, a union so robust th...nd Stevens, an author of the paper who has studied botulinum toxins for many years. The toxins responsible for botulism are produced by the bacterium Clostridiu...Seeing a neurotoxin's deadly grip
...ntly have discovered new information about how the botulinum neurotoxin shuts down neurons with deadly efficien...re are seven structurally and functionally related botulinum neurotoxins (BoNTs), called serotypes A through G, with each acting in a slightly different manner. ...Botulism study could lead to new vaccines and treatments to counter bioterrorist attacks
... in the bioterrorist arsenal, none is as potent as botulinum neurotoxin, which causes botulisma potentially fat... the limbs and respiratory muscles. Just 1 gram of botulinum neurotoxin, evenly dispersed and inhaled, could kill more than a million people, according to a 2001...Study helps explain why botulinum toxin is so deadly
...rch Institute shows how the astonishingly powerful botulinum toxin uses a similar strategy to latch onto nerve ... blocking this signaling molecule, tiny amounts of botulinum toxin can cause paralysis and even death through respiratory failure. The bacteria that makes this t...Three UCSF faculty elected to Institute of Medicine
...oclonal antibodies that potently neutralize type A botulinum neurotoxins and which can be mass produced to prevent or treat botulism. John L.R. Rubenstein, MD, PhD, is the Nina Ireland Distinguished Professor in Child Psychiatry and a basic science researcher in the Department of Psychiatry at UCSF. His r...Encoded metallic nanowires reveal bioweapons
...allpox virus, and protein toxins such as ricin and botulinum toxin. If a simultaneous test for all of these is desired, the anthrax antibody would be attached to stripe pattern 1, the smallpox antibodies to stripe pattern 2, and the toxin antibodies to stripe pattern 3, for example. If the corresponding model ...Technique used commonly in physics finds application in neuroscience
...e technique also to develop a sensor for detecting botulinum toxin, responsible for an often fatal type of food poisoning. "Our sensor is extremely sensitive because it is capable of detecting interactions between two single molecules," Mohideen said. "As a result, the sample size you need for testing can...Researchers discover botulism toxin's insidious route into nerve cells
... neurotoxins produced by the bacterium Clostridium botulinum -- enters nerve cells has proved elusive for scien...s that it has identified the cellular receptor for botulinum neurotoxin A. The group's work was published in the March 16, 2006, edition of ScienceXpress, which ...Scientists reveal how deadly toxin hijacks cells
MADISON - Scientists have pinpointed exactly how botulinum neurotoxin A - a potential agent of biological war...ich may block the entry of toxins into cells." The botulinum toxins, of which there are seven types, are made by a bacterium commonly found in soil, known as Clo...Newly discovered small molecules
...oratory that conducted the study, said, "Since the botulinum neurotoxin is the most poisonous toxin known, finding a compound to activate it might seem somewhat counterproductive. But the range of clinical uses for the toxin have increased well beyond its cosmetic use--multiple sclerosis, stroke, cerebral pals...Tips from the journals of the American Society for Microbiology
...rapid simultaneous detection of staphylococcal and botulinum toxins in food. Their findings appear in the Sept...crobiology. Staphylococcal enterotoxin B (SEB) and botulinum toxin A (BotA) are common causes of food poisoning in humans and pose high risk as potential biologi...Tetanus toxin found to have therapeutic properties
...in is a neurotoxin belonging to the same family as botulinum neurotoxins, which cause botulism. These have been successfully used as a therapy to treat disorders caused by abnormal muscular contractions such as strabismus, cerebral palsy, anal contractions and torticollis. Recently these toxins have been used ...Tips from the journals of the American Society for Microbiology
...searchers found genetically similar isolates of C. botulinum in both. The study noted that the child had been ...tulism were identified. "For the first time the C. botulinum isolates from an intestinally colonized infant and from household dust from the infant's home were d...Researchers show how botulism toxin ensnares its target
...ites, Breidenbach created crystals of a particular botulinum neurotoxin bound to its target SNARE. The research...s compared the amino acid sequences of the type of botulinum toxin they studied with other known toxin sequences, they found that the region they had found to co...Scientists solve the mystery of how Botox attacks nerves and eliminates wrinkles
...ous substances known. Exposure to large amounts of botulinum bacteria can cause a paralytic, sometimes-fatal di... a cheap, non-FDA-approved imitation of Botox. The botulinum toxin works by invading nerve cells, where it releases an enzyme that prevents muscle contraction. I...