Hot on the TRAIL of controlling inflammation in bacterial meningitis
...mmation of the spinal cord and brain, which causes brain cell death in this life-threatening disease. Pne...lammation of the protective membranes covering the brain and spinal cord and is caused by infection with the bacterium Streptococcus pneumoniae. The observed...JCI table of contents: June 14, 2007
...mmation of the spinal cord and brain, which causes brain cell death in this life-threatening disease. Pne...lammation of the protective membranes covering the brain and spinal cord and is caused by infection with the bacterium Streptococcus pneumoniae. The observed...A possible mechanistic link between stress and the development of Alzheimer tangles
...llary tangles. While plaques accumulate outside of brain cells, tangles litter the inside of neurons. They ...when you think about stress-induced changes in the brain is glucocorticoids because they are such pervasive mediators of stress responses, says Rissman. But ...Study suggests other causes for childhood brain aneurysms
...the commonly held scientific belief that childhood brain aneurysms are caused by trauma, infection or underlying vascular malformations. In a retrospective review of 53 Ohio children with intracranial (brain) arterial aneurysms, Todd Abruzzo, MD, found that the most common type of aneurysm among all age ...Other highlights in JNCI, June 12
... multiforme, the most aggressive form of a type of brain tumor called glioma. The median survival for pa... lines, in samples from glioma patients and normal brain tissue, and in mouse models. They found that the overexpression of the CCRK gene was associated w...NIH awards nearly $21 million to fund cutting-edge research equipment
...of performing such demanding studies as functional brain and cardiac imaging in a variety of animal species..., as well as investigations involving neuronal and brain slice imaging. At the University of Wisconsin School of Medicine and Public Health in Madison, pos...Researchers identify fifth gene responsible for Joubert syndrome
...he cerebellum and brainstem, the structures in the brain that coordinate movements and regulate basic funct...ance imaging (MRI), where the abnormally developed brain stem resembles the shape of a molar tooth. The researchers discovery of mutation in the gene (RPGRIP...Scientists propose the kind of chemistry that led to life
...d process: different rates of neuron firing in the brain lead to new connections between neurons and ultimately to the mature wiring pattern of the brain. Similarly, social ants first search randomly, then discover food, and finally build a short-term memory for the entire colony using chemical trails. T...Agonized death throes probable cause of open-mouthed, head-back pose of many dino fossils
... results from the agonized death throes typical of brain damage and asphyxiation, according to two paleonto...many other possibilities exist, including disease, brain trauma, severe bleeding, thiamine deficiency or poisoning. "This puts a whole new light on the mod...Hormone that signals fullness also curbs fast food consumption and tendency to binge eat
...thought to control food intake by signaling to the brain when we are full, said Christian Weyer, M.D., the ... many diet pills, which typically block individual brain chemicals, hormone-based therapies such as pramlintide work by enhancing existing physiological path......exts in which episodes occur engages a part of the brain called the hippocampus. The laboratory of Nobel La...ule (the NMDA receptor) in a particular network of brain neurons (the dentate granule cells of the hippocampus) is essential for these rapid discrimination p...2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
...ation into the relationship between an individuals brain chemistry and his report about his behavior toward...f molecular imaging is its ability to relate human brain chemistry and behavior, said Henry N. Wagner Jr., SNM past president and historian, who announced th...Genetic 'fellow traveler' discovered in Alzheimer's
...he abnormal formation of protein tangles that kill brain cells, said the researchers. To explore the genes role, they experimentally silenced the gene in neurons, observing an increase in the form of a key protein that contributes to such tangles. Discovery of this novel LOAD susceptibility gene provides...University of Pittsburgh scientists find new contributor to aggressive cancers
...f cancer, including cancer of the prostate, liver, brain (glioblastoma) and muscle (leiomyosarcoma). They found mutations in the integrin 7 gene, particularly those that resulted in an abnormally shortened protein product, or truncation, in 16 of 28 prostate cancers. They also found truncation-inducing ...New clues to stroke role in Alzheimer's
... discovered key details of how stroke or traumatic brain injury can trigger Alzheimers disease (AD) by enha...nts established that executioner enzymes that kill brain cells during stroke or head trauma also interfere with the normal disposal of an enzyme that helps g...Crucial progress in understanding Fragile X mental retardation protein
...loss of FMRP, which is abundantly expressed in the brain and testes. Without this protein, brain development is hampered and nerve cells cannot communicate with each other appropriately, resulting ...Neuronal activity gives clues to working memory
...oups of cells," Dr. Aksay says. But how do these brain cells communicate which each other to coordinate t...quite difficult to test the function of individual brain cells in primates and higher animals during behavior, but the goldfish's memory centers are much mor...Research team identifies new Alzheimer's gene
...gest the healthy form of the GAB2 gene may protect brain cells from developing tangles, one of the hallmark...at the GAB2 gene is unusually active in vulnerable brain cells from Alzheimers patients and that the GAB2 protein produced by this gene is present in those b...Cancer drug enhances long-term memory
...n the untreated mice. The scientists also examined brain tissue and found that neural connections in the hippocampus were stronger in the samples treated with HDAC inhibitors. After an event, a critical window exists when memory consolidation is occurring. During that time, genes associated with memory n......ient in Plexin-B2 ( Plxnb2 -/- ) displayed severe brain abnormalities, including failure of neural tubes to close (exencephaly). These defects arose from retarded GPC proliferation and migration. Hypertrophied ventricular zones of all Plxnb2 -/- mice, even the small proportion without exencephaly, indic...