Multicenter study nets new lung tumor-suppressor gene
...orming. Mutated versions may be unable to act as a brake on cancer. To find out, the investigators ran a series of experiments in mice with a defective form of a gene called Kras, which drives the formation and growth of lung cancer. They tracked the development of lung cancer in animals with mutated LKB...A new brake on cellular energy production discovered
...w identified the first known factor that acts as a brake on cellular energy production. Mitochondria release energy through a process known as cellular respiration - a chemical process inside each mitochondrion that results in the production of the cell's energy currency, the molecule ATP. As importan...American Chemical Society's Weekly PressPac -- July 18, 2007
...o-sized generator gets big power boost Automobile brake linings, tires remain major sources of toxic metal... ARTICLE #3 FOR IMMEDIATE RELEASE Automobile brake linings, tires remain major sources of toxic metals Environmental Science & Technology Particl...Researchers shed light on mechanism of action used by anti-cancer drug
...known as eIF2, a process that serves as a critical brake on protein translation in cells subjected to ER stress. Interestingly, they also found that sorafenib, by virtue of its ability to inhibit Raf, also prevented an increase in expression of a chaperone protein known as Grp78, which is classically induc...Common cancer gene sends death order to tiny killer
...e or miR-34a to stem tumor development, there's no brake in pancreatic cells and uncontrolled growth leads to cancer," says Anirban Maitra, M.B.B.S., associate professor of pathology, oncology and genetic medicine. Mendell and his team are looking for missing miR-34a in other cancers. If it's a widesprea...... been well studied, mechanisms that might act as a brake are poorly understood," said Solaro. "Identification of this previously unknown molecular mechanism for slowing the heartbeat may offer new avenues of diagnosis, drug design and treatment of many common heart diseases," said Solaro. "Further, now...Salk scientists hammer out a pathway that promotes muscle cell survival in mice
...cific genes in response to exercise by releasing a brake that normally keeps these genes off. Learning how ...lase (HDAC), stuck in place. Without loosening the brake by a chemical modification process known as phosphorylation, muscle-specific genes could not be acti...Largest physics meeting of the year, in Denver
...). LED light flourishes in niche markets, such as brake and traffic lights, and future conquests are in sight. Efficiencies of 138 lm/W have been achieved in the lab (but not yet in commercial devices) for low power devices and over 90 lm/W for high power devices. According to George Craford (Philips Lum...'Electric' fish shed light on ways the brain directs movement
... moving tube. "The fish were able to accelerate, brake and reverse direction based on a cascade of adjustments made through their sensory and nervous systems, in the same way that a driver approaching a red light knows he has to apply the brakes ahead of time to avoid overshooting and ending up in the mi...New test predicts blood cancer's sensitivity to experimental cancer drug
...ff, restrained only by its emergency brake; if the brake was released, the car would plunge over the cliff. Drugs such as ABT-737, in effect, release the brake. The drug molecules liberate the pro-death signaling molecules from their Bcl-2 captors. These pro-apoptosis molecules -- a key one is called BIM...JCI table of contents: January 2, 2007
...s ABT-737 that directly release the anti-apoptotic brake provided by BCL2 sequestration of BIM might provide effective therapeutics for the treatment of this cancer. TITLE: Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737 AUTHOR C...New study shows promise of toxicogenomics in environmental monitoring
...als are also used in industrial parts ranging from brake pads to batteries, and can be found in urban runoff. For the study, the researchers chose sublethal exposure levels that are comparable to what is found in the environment. For each metal, the researchers found a decrease in the expression of alp...Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
...tein called Scp1, at will. "Scp1 is an important brake that regulates the transition from neuronal precur...cal Institute investigator at Salk. "Loosening the brake with an inhibitor would allow us to influence the timing of neuronal differentiation," he adds. A...A switch between life and death
...o shut down cell division. With bantam around, the brake is off, and they continue to divide." Cohen and his lab have been studying microRNAs like bantam for some time because of their important role in the regulation of many vital processes across species. The next step will be to identify the RNAs that ...Think fast! Rice undergrad unlocks nerve speed secret
...r," McNew said. "We also knew there was a chemical brake in the system, something that held the pre-positio...r release. These new studies clearly show that the brake is a protein called complexin." Rice's study, which was conducted in McNew's lab, largely by under...Molecular 'brake' found for neurofibromatosis 1
...tially troublesome tumors along nerve fibers. This brake is a protein that appears to stop the cascade of molecular events that leads to the activation of a cancer-producing gene, or oncogene, that causes the tumors. The oncogene, called Ras, was one of the first oncogenes ever discovered and has been impl...Protein from the wrong side of the tracks aids cancer virus
...ruses, Green says. "We believe that HBZ acts as a brake on viral replication," he says. "Without HBZ, the virus replicates too fast, producing its proteins so quickly that the immune system readily detects infected cells and eliminates them." Green and his colleagues are now testing that hypothesis....Harvard Medical signs agreement with Merck to develop potential therapy for macular degeneration
...ay to stop the formation of lipofuscin is to put a brake on the vision cycle. In a 2005 issue of Biochemistry, Dr. Rando and his collaborators reported finding key elements in the visual cycle pathway and designed a group of novel small molecule antagonists for some of them. Their approach is illustrated b...Researches discover gene critical for protection against septic-shock-induced death
...se. "Sepsis syndrome is like a speeding car with a brake failure. Nrf2 may function like a brake that regulates the speed," said Biswal, senior author of the study and assistant professor in the Bl...Mutation in a single gene switches a fungus-grass symbiosis from mutualistic to antagonistic
... colonization of the host. Thus, the ROS act as a brake on the growth of the fungus, preventing it from becoming pathogenic and allowing it to maintain a beneficial, mutualistic symbiosis with the plant. When this gene is disrupted, the growth of the fungus is uncontrolled and the association becomes pat...