Gene linked to greater risk of heart disease in type 2 diabetes
...n contributing to atherosclerosis -- the dangerous buildup of plaque that can lead to partial or complete blockage of the artery, leading to heart attack or stroke. In the first part of this study, the researchers mapped the structure of the CD36 gene, which consists of hundreds of nucleic acids strung toget...Trojan-horse therapy blocks buildup of Alzheimer's plaque
...eople with Alzheimer's disease develop through the buildup of amyloid protein chains from individual units called A peptide. "There have been many attempts by pharmaceutical companies to develop A peptide inhibitors -- mainly by screening for small molecules that would bind to those aggregates and hoping tha...Research uncovers role of Apolipoprotein E in Alzheimer's disease
...n that the inflammatory protein ApoE can speed the buildup in the brain of amyloid plaques, the major pathological hallmark of Alzheimer's disease. These deposits of plaques are composed primarily of the amyloid-beta protein (AB). However, the mechanism by which ApoE exerted its ill effects on Alzheimer's d...Fat buildup found in hearts of obese or diabetic heart failure patients
...to the heart. What we are finding now is that the buildup of fat doesn't stop in the blood vessels, it's act...iling hearts. The research team associated this buildup of triglycerides in the heart muscle, called lipotoxicity, with dysfunctional expression of genes re...Study links polycystic ovary syndrome with early vascular changes of heart disease
... alone and endangers their hearts by causing early buildup of calcium in coronary arteries, researchers at the University of Pittsburgh's Graduate School of Public Health report in the November issue of the Journal of Clinical Endocrinology and Metabolism. "Our findings indicate a strong correlation between ...New gene therapy promising for treating Fabry disease
...ple. Due to genetic defects, Fabry patients have a buildup of lipids (fats) in endothelial cells lining vessel walls, causing constriction. Eventually, cardiac disease, kidney disease or strokes result. "Patients with Fabry disease either don't make enough of the enzyme alpha-galactosidase A or improper syn...Gene therapy shows promise in model of Parkinson's disease
... Both these forms of the disease involve buildup of alpha-synuclein in the cell, and result in cell degeneration and death. All the evidence pointed to the possibility that parkin might play an important role in protecting neurons from toxic overaccumulations of alpha-synuclein. Aebischer, PhD stud...Dwarf mistletoe reveals its sexual secrets
...ich the seed blasts out of the fruit. This extreme buildup of water pressure as a seed dispersal system is rare in the plant world," says Dr. Cynthia Ross, an assistant professor at the University College of the Cariboo in Kamloops, British Columbia. Dr. Ross, who describes herself as a "plant gynecologis...Gene vaccine for Alzheimer's disease shows promising results
...r's disease, immunization with amyloids slowed the buildup of plaque on the brain and appeared to slow cognitive loss. "Although human clinical trials are still at least two years out, theoretically, we are on the right track," he said. Other UT Southwestern authors involved in the study were Dr. Liping Li,...Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
... molecular chain of events from eating fats to the buildup of cholesterol and triglycerides in the blood were unknown. "What we have found is a missing link, a mechanism by which saturated fats and trans fats can do their dirty work," said Spiegelman, who carries out basic research on fat cells and metabolic...Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers
...r bodies is equally important to prevent its toxic buildup in tissues. "Even in our own case, our bodies have to supply oxygen to our tissues, but they must also keep out excess oxygen to prevent oxidative damage to the tissues. This damage is closely related to aging. Hence, perhaps, the many anti-oxidative......off the atoms by the strong laser field impede the buildup of an intense wave from the faint "atomic" waves. The Vienna-Wrzburg-Munich team have overcome these problems by irradiating the atoms with the world's shortest high-intensity laser pulses, lasting merely 5 millionths of a billionth of a second (=...Researchers investigate 'whole farm' approach to reduce dairy pollution
... looking at how a single change affects phosphorus buildup and runoff, researchers will investigate how the various strategies reinforce one another. "It's really a matter of fine-tuning a system that isn't necessarily broken but could run better," Muir said. "We have also included the dairymen as full partn...UCI researchers identify trigger for onset of Alzheimer's, aiding search for new therapies
...researchers found occurred in combination with the buildup of beta amyloid in neurons of the hippocampus, amygdala and cerebral cortex regions of the mice's brains. While the hippocampus is thought to play a key role in learning and memory formation, the amygdala is involved in computing the emotional signi...Researchers develop mouse model for studying blinding diseases in humans
...lipofuscin (including the fluorophore A2E). This buildup of waste causes degeneration of the RPE cells in the central retina and results in progressive vision loss in both humans and mice with the mutation. "To date, these mice provide one of the best models to study both Stargardt disease and a dry form ...Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
.... The AIM-protected macrophages go on to encourage buildup of fats on the interior walls of arteries, accordi...raging other cells to accumulate and worsen plaque buildup in arteries. "The oxidized lipids are cleared out by macrophage cells, but the lipids themselves are...Winners of Tyler Environmental prize announced
...heory of climate change. His record of the gradual buildup in atmospheric carbon dioxide since 1958, measured high on the mountain Mauna Loa in Hawaii, has come to be known as the Keeling curve. Keeling developed the first instrument and the techniques to measure atmospheric carbon dioxide concentrations ac...Fish oil holds promise in Alzheimer's fight
...an biology--the high-DHA group had 70-percent less buildup of amyloid protein in the brain. This sticky protein makes up the plaques, or patches, that are a hallmark of Alzheimer's. A similar study by Cole's group published in Neuron last fall showed that DHA protected against damage to the "synaptic" area...Researchers discover molecule that causes secondary stroke
...tment researcher Joseph Clark, PhD, results from a buildup of toxins caused by bleeding from the initial stroke. "Normally the cerebral spinal fluid that envelopes the brain carries off wastes and exchanges them for nutrients at what's called the blood-brain barrier," Dr. Clark says. "After a hemorrhagic str...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...ntroduce the functioning gene and correct glycogen buildup in heart and skeletal muscle. The findings suggest that such an approach should be considered as a potential gene therapy strategy for Pompe disease patients, the researchers report in a forthcoming issue of Molecular Therapy (now available online). ...