UCSF study shows suppression of telomerase enzyme can inhibit spread of melanoma
...gment." "As the cells become too acidic from the buildup of lactic acid, the proteins that control pigment production can be turned off, suggesting that glucose metabolism plays a key role when combined with telomerase in metastasis." The ribonucleoprotein enzyme, telomerase, was discovered by study co-i...Nanotechnology enables low-dose treatment of atherosclerotic plaques
... on line. An atherosclerosis plaque results when a buildup of cholesterol, inflammatory cells and fibrous tissue forms inside an artery. If a plaque ruptures, it can block blood flow to the heart or brain, causing heart attack or stroke. While growing, plaques require an influx of nutrients, fats and cells, ...Tiny inhaled particles take easy route from nose to brain
...lar stress response, but they do not know yet if a buildup of ultrafine particles causes brain damage, said lead author Alison Elder, Ph.D., research assistant professor of Environmental Medicine. The study tested manganese oxide ultrafine particles at a concentration typically inhaled by factory welders. ...Wildlife Conservation Society joins Climate, Community & Biodiversity Alliance
...he unprecedented pace of climate change due to the buildup of greenhouse gases in the atmosphere," said Dr. John G. Robinson, Executive Vice President of WCS. "With over 500 projects in more than 60 countries around the world, WCS can place its tangible, field-based knowledge of how to protect forests and ot...Scientists discover age-regulated cellular activities that protect against protein aggregation
...ed the high molecular weight aggregates-the plaque buildup in the animals," explains Dillin. But the researchers also noticed an unexpected phenomenon. "Curiously," Dillin continues, "some animals were totally protected from proteotoxicity despite having high molecular weight aggregation buildup, while ot...'Sticky' mice lead to discovery of new cause of neurodegenerative disease
...ene are not executed properly, leading to a lethal buildup of malformed proteins in brain cells. The new st...n Laboratory point to a novel mechanism behind the buildup of the toxic sludge that accumulates in neurons. Researchers have long known that neurodegenerative ...Genetic clues to cardiomyopathy's origins revealed in mice
...mised, leading to dilation of the right ventricle, buildup of scar and fatty tissue, and arrhythmia. Towbin calls ARVC "underrecognized" in the United States primarily because of its relative newness and difficulty evaluating the right ventricle technically, which can lead to misdiagnosis and improper trea...Cholesterol implicated in progression of fatty liver disease
...rs that cause damage to the liver, they found. The buildup of other forms of fat in the liver, including free fatty acids and triglycerides, were insufficient to spark the events leading to worsening disease. The findings suggest a key role for the type, as opposed to the amount, of fat in susceptibility t...Researchers identify key step in cocaine-induced heart enlargement, sudden death
...s commonly sold on the street, causes the abnormal buildup of primitive proteins in heart muscle a process causing heart enlargement that can ultimately lead to sudden death, report researchers at the University of South Florida College of Medicine and James A. Haley Veterans' Hospital. The study was publ...Closing in on lethal heart rhythm in young athletes
...g structure. The inherited condition leads to the buildup of excess fatty and scar tissue in the heart's right ventricle, causing irregular beats and - unless diagnosed and treated with drugs or implanted defibrillators - triggering a fatal heart rhythm disturbance. Judge, an assistant professor at The Jo...Professor earns carbon sequestration research grant
...phere, underground or in oceans, which reduces the buildup of carbon dioxide--principally greenhouse gas--concentration in the atmosphere. The funding supports Dunia Urrego, a Florida Tech post-doctoral fellow leading the research under Bush....Cabernet sauvignon red wine reduces the risk of Alzheimer's disease
... levels of beta-amyloid peptides that cause plaque buildup in the brain, which is the main characteristic of AD. An estimated 4.5 million Americans have AD. Presently, there are no known cures or effective preventive strategies. While genetic factors are responsible in early-onset cases, they appear to play ...NASA satellite data helps assess the health of Florida's coral reef
... data was also used to measure the cumulative heat buildup over several weeks, shown to be particularly important to the health of reefs. "MODIS imagery is beneficial because it provides more detail than traditional satellites, allowing us to detect conditions down to hundreds of meters - the size of indiv...New study finds chocolate chip cookies lower cholesterol
...ased formation of fatty substances and cholesterol buildup in the arteries, even for individuals with total cholesterol levels under 200 mg/dl. The randomized, double blind study researched 33 healthy adults with moderately high cholesterol between the ages 3565 at the University of Connecticut, Storrs, CT...Seals protect brain, conserve oxygen by turning off shivering response on icy dives
..., seals maintain aerobic metabolism, avoid lactate buildup that occurs in the face of insufficient oxygen and require little time to recover, Folkow explained. Seals often spend 80-90% of their time at sea underwater, he said. Seals in the wild occasionally dive for so long that they use nearly all their o...Two drugs may stabilize plaques in atherosclerosis
...de arterial walls, which is a key component of the buildup of plaque that leads to a narrowing of the arteries and increases the risk of heart attacks and strokes. With the growing understanding that atherosclerosis, also known as hardening of the arteries, is in part an inflammatory disease, Mishra noted t...Gene linked to aggressive 'wet' age-related macular degeneration
...eveloping the wet form of AMD. According to Hoh, buildup of abnormal blood vessels in Caucasian patients is compounded by development of large waste deposits called drusen. Chinese patients, she said, develop little to no drusen and progress directly to wet AMD. This study demonstrates that these two major...Genetic experts investigate causes of harmful metabolic disorder
...erance and blood-fat disorders that promote plaque buildup in the artery walls. Deka and his team will attempt to establish a genetic basis for metabolic syndrome by identifying chromosomal regions associated with it. They will collect data from a genetically isolated population of about 80 large families ...Factors affecting kernel yield in maize
...ly as a mechanism for circumventing toxic ammonium buildup resulting from abnormally low GS1 activity. Phloem sap analysis revealed that, unlike glutamine, asparagine is not efficiently transported to developing maize kernels, which could account for the reduced kernel production in the mutants. Constitutive...After 2 years, study shows Revlimid patients live longer and remain transfusion free
... month. Repeated transfusions can lead to a toxic buildup called "iron overload" that severely damages the heart, liver and pancreas, and patients eventually succumb to the disease. The data presented by List showed that two-thirds of patients who received Revlimid were completely freed from the need for ...