NIH awards Emory and Georgia Tech $10 million for partnerships in cancer nanotechnology
...and proteins, potentially identifying and treating cancerous cells at much earlier stages than currently possible. The National Cancer Institute has awarded a five-year grant of $7.1 million to establish a multidisciplinary Bioengineering Research Partnership (BRP) in cancer nanotechnology. ...Stony Brook University medical researcher developing new medication to prevent colon cancer
...ently not diagnosed in its earliest stages because cancerous lesions in the colon grown slowly and often without symptoms. More than 148,000 new cases of colon cancer are diagnosed in the U.S. each year and more than 56,000 Americans die of the diseases annually, according to the American Cancer Society. In...Genetic data crunching achieves milestone at Stanford
...pecially useful for comparisons between normal and cancerous tissues or between different stages of development. Researchers use them to nose out the genes associated with such changes. The problem, however, is that experiments with microarrays yield vast amounts of data. "Microarrays allow researchers to do i...Molecule that helps DNA replicate may make good target for cancer therapy
...in stopping the uncontrolled cell division seen in cancerous tumors. The work grew out of a desire to learn the identity of the "tugboat," said Anja Bielinsky, an assistant professor of biochemistry, molecular biology and biophysics, in whose laboratory the work was performed. The first author on the paper is ...Newly discovered protein suggests novel tumorigenic pathway
...hat cells with impaired PICT-1 function may become cancerous because of the resulting instability in PTEN. This would represent a new tumorigenic pathway that is not due to a defective PTEN gene but rather a loss of PTEN function caused by PICT-1. If this is the case, then this new type of tumor may be treat...NYU team develops enhanced algorithm for detecting changes in cancer genomes
...ism data and were unable to separate variations in cancerous and non-cancerous genes in a single framework. Mishra's team, which forms NYU's Bioinfomatics Group, has previously examined new genomic technology for mapping and sequencing with single molecules, models of genome evolution, and computational and sy...New gene target found for common brain tumors in children
...ctivation of all Notch proteins, reduces growth of cancerous cells in culture by 80 percent, although unwanted side effects and dosing problems may make it a poor choice for treating human brain cancer. But the investigators are testing more potent drugs of the same class and developing new ones that block on...By impounding iron, FHC foils cell suicide, fuels inflammation
...il to die, plays a key role in the accumulation of cancerous cells and then protects those cells from radiation and chemotherapies designed to provoke tumor cell suicide. Drugs that inhibit NF-kB are already in use for inflammatory bowel disease and certain cancers, such as Hodgkin's lymphoma and multiple myel...JCI table of contents, December 1 2004
...h normally attack and destroy foreign, infected or cancerous cells to act against tumor-derived cells. This data indicates that NK cells are key players in tumor surveillance in such malignancies. The authors suggest that people deficient in TYK2 may be predisposed to the formation of tumors. In addition, the...Encouraging results from validation study of trial of personalized treatment in breast cancer
...hival tumor material of 291 node negative (without cancerous cells in the lymph nodes) patients aged < 60, diagnosed through 1998, and who had received only surgery or radiotherapy. The 70-gene signature outperformed existing standard criteria (St. Gallen, Nottingham Prognostic Index, and Adjuvant Online) ...Gene therapy reduces skin cancer to sunburn in mouse model
...tations in the gene Xpa suffer from XP and develop cancerous lesions on their skin within three weeks after UV light exposure. Dr. Errol Friedberg, professor and chair of pathology at UT Southwestern, in collaboration with Dr. Carlos F.M. Menck of the Institutes of Biomedical Sciences in Sao Paulo, Brazil inje...Purdue scientists hunt for 'secret X' to treat liver cancer
...sed on the X protein could potentially target only cancerous cells, slowing their growth." The research, whi...ells in the body - the healthy ones along with the cancerous ones - we would like to target the cancer cells alone. We are taking the next steps toward that goal...Vitamin E in plant seeds could halt prostate, lung cancer, says Purdue scientist
... to test their hypothesis they exposed cultures of cancerous prostate and lung cells to the vitamin. Normal prostate epithelial cells were used as a control group. "We discovered that as we increased the quantity of gamma-tocopherol, the cancer cells grew more slowly," Jiang said. "But the normal prostat...New pathway identified in angiogenesis
...harmful when it creates new feeder lines that help cancerous tumors grow and spread. Investigators in The Ohio State University Davis Heart and Lung Research Institute say angiogenesis appears to be manageable by stimulating monocytes certain white blood cells in the immune system with high doses of a nat...JCI table of contents, December 15 2004
...apysimultaneously facilitating metastasis of their cancerous cells?" Gutpa and Massagu stress that any effective therapies that modulate platelet activity will need to be specific for the pathological tumor cellplatelet interaction, without effecting normal platelet function. Platelet-specific integrin inhibit...Fundamental finding yields insight into stem cells, cancer; opens door to drug discovery
...he hedgehog pathway can lead to the development of cancerous tumors. The researchers report their findings in the Dec. 24, 2004, issue of Science. The work was funded by the National Institutes of Health. "Studies have found a wide breadth of functions for beta-arrestins, but none had revealed a role for these...Scientist discover the cellular roots of graying hair
...es of melanocytes, which are the cells that become cancerous in melanoma, we would love to identify a signal that would make a melanoma cell stop growing." Fisher and the report's lead author, Emi K. Nishimura, MD, PhD, also of the melanoma program, are in the Department of Pediatric Oncology at Children's Ho...UCSD discovery shows how embryonic stem cells perform 'quality control' inspections
...fic cell types, thus preventing the development of cancerous cells." "These findings will open new avenues of research for those of us who study mouse embryonic stem cells on how these cells maintain genetic stability and self renewal," he adds. "They will also provide a foundation for future studies inv......t, unknown. This is important because what makes a cancerous cell different from a noncancerous cell is the set of genes that are turned on or off. These instructions or regulatory regions are believed to be far more numerous than genes, but it was not clear how to identify them." "We developed a novel techniq...... compound is found in all cells and, therefore, in cancerous cells. And this is why the metastasis regenerates. Thus, in order to obtain beneficial effects using IL-2, the glutation in tumorous cells would have to be reduced in an alternative manner, and this was achieved by means of oxothiazolidine-carboxilat...