Children's Hospital Oakland, Calif.'s new iron regulation discovery
...roblem with targeting DNA is that both healthy and cancerous cells have the same DNA, but they also have different mRNAs. Consequently, our research findings could help scientists design medications that target mRNAs," said Dr. Theil....Profiling of cancer genes may lead to better and earlier detection
... analyzed 45 of these new genes in both normal and cancerous tissues from the same patients and found that many of the genes were methylated specifically in the tumor samples. "We ended up with a large number of genes that are involved in the development of lung cancer that, despite years of work in the fie...Two studies: Speeding development of novel tracer for prostate cancer
...tient, and it is drawn in higher concentrations to cancerous areas. The highly sensitive PET scan picks up the metabolic signal of actively growing cancer cells. The CT scan generates a detailed picture of internal anatomy, locating and revealing the size and shape of abnormal cancer growths. When these two re...'PET/CT in Cancer Patient Management' examined in Journal of Nuclear Medicine Supplement
...harmaceutical is drawn in higher concentrations to cancerous areas. The highly sensitive PET scan picks up the metabolic signal of actively growing cancer cells. The CT scan generates a detailed picture of internal anatomy, locating and revealing the size and shape of abnormal cancer growths. When these two re...Other highlights in the January 3 JNCI
...otein, a step that often leads to the death of the cancerous APL cells. Contact: Susan E. Knapp, Dartmouth Medical School, 603-646-3661, Susan.E.Knapp@Dartmouth.edu Study Examines Drug Delivery With Liposomes Several chemotherapy drugs can only be given at certain doses because they're highly toxic...Jefferson scientists find guardian gene's choices crucial to stopping cancer process
...cision." "p53 is such an important player in the cancerous process it's nearly always mutated or inactivated in cancer that continuing to understand more about how it works will likely have significant implications for cancer research," says Dr. McMahon. "We wouldlike to understand the interplay between th...Scientists discover how body fights to control spread of cancer
...ctive shield of a protein called MUC1 in which the cancerous cells are eventually destroyed by our immune system. Scientists have now discovered how this protective shield is broken down, allowing cancer to spread throughout the body. Dr Lu-Gang Yu, from the University's School of Clinical Sciences, explains...JCI table of contents -- January 11, 2006
...ors One feature of tumor cells that makes them cancerous is their ability to grow in the absence of the signals that normal cells require to grow. For example, breast cancer is often associated with the ability of the tumor cells to grow in the absence of a growth factor known as EGF. In many cases, the tu...Researchers first to map gene that regulates adult stem cell growth
...gene plays in transforming healthy stem cells into cancerous ones, such as in leukemia and lymphomas. If the gene does in fact play such a role, it is possible that it also could provide the keys to new therapies. Van Zant describes his discovery as an elation. He worked on the project for six years with Ying...'Quiet revolution' may herald new RNA therapeutics
...R gene could help prevent the growth of neoplastic cancerous cells, ordinary cells which develop into tumour cells, such as in prostate cancer cells," explains Dr Akoulitchev. "In fact, the first anti-cancer drug, Methotrexate, acts by binding and inhibiting the enzyme produced by this gene." Dr Akoulitchev ...New test predicts blood cancer's sensitivity to experimental cancer drug
...year, is an easy mark for the new drug because the cancerous cells are strongly dependent on a particular survival molecule, Bcl-2, that keeps the self-destruct signals at bay. They showed that the investigational drug neutralizes the Bcl-2 action, unleashing molecules that trigger suicide in the cancer cells,...Scientists identify pancreatic cancer stem cells
... in pancreatic cancer, the research team implanted cancerous tissue from human pancreatic specimens removed during patient surgery in "xenograft" mice with compromised immune systems. Researchers removed tumors after they grew, and then sorted millions of cancer cells to isolate those that had one or more of t...Good for the goose, not so great for the gander
... p53 gene, which encodes a protein that suppresses cancerous growth but also shortens life span. Scientists' initial surprise at these results was rooted in the assumption that aging was biologically identical in male and female. It's an assumption Tower began to seriously question about a year and a half ag...New medications, cancer diagnosis goals of UH engineers with $1M in grants
...tes. A small biological sample suspected of being cancerous would be extracted from a patient using a nearly p...mples bond. Should bonding occur, the presence of cancerous cells would be confirmed. The key advantage of such a system, Willson said, is that it would com...Cancer cells more likely to genetically mutate
...s. That chemotherapy drug may kill off some of the cancerous cells, but millions of other cells in the tumor will live on. To be effective, a chemotherapy treatment may have to target more than one oncogene so-called combination chemotherapy. Not all of the news is bad, though. Loeb believes this research ...CSHL researchers show RNA splicing factor may be new target for cancer therapy
...novel variant of this kinase, S6K1, can make cells cancerous and appears to be required to maintain some tumor cells in a cancerous state.......ours. Van Lohuizen has found that stem cells in cancerous tissues are locked in an immature state in which t...as seen that the cells become invasive and trigger cancerous growth. This may be why gliomas are such lethal tumours, because these stem cells become highly migr...CSHL research ties harmless viruses to cancer
...bnik. According to this model, cells can be made cancerous by viruses that fuse cells. Fusion abruptly unites two or three cells under the same membrane, a change that triggers massive CIN and creates diverse cells whose properties change over time. The researchers found that some of these cells can become c...Genetic analyis for personalizing of treatment of lung and colon cancer, certain sarcomas
... of a genetic analysis of a blood sample or of the cancerous tissue where the existence of certain mutations or polymorphisms are observed and enable us to predict what drugs are the most suitable for that particular patient. The analysis provides us with information about the most effective therapeutic option......ch and the Ovarian Cancer Institute (OCI). Using cancerous and non-cancerous tissue straight from the operating room, Bowen and fellow OCI researchers are engaged in investigating the molecular profile of ovarian cancer tissue in order to discover the causes of ovarian cancer, develop a reliable diagnostic b...