Speeding discovery of the 'human cancer genome'
...he ride with those that actually contribute to the cancerous cells' ability for unchecked proliferation or spread. Simply sorting through those differences one by one takes time and money, said Lynda Chin of the Dana-Farber Cancer Institute and Harvard Medical School. "There has to be a way to prioritize ...Coming soon: 3-D imaging that flies 'through' and 'around' cancer
...a with accurate anatomical information of possible cancerous tumors--from inside the body--provides a visual na... peel away the organs, highlight tumors and detect cancerous 'hot spots'--providing an omnipotent perspective of the body," he indicated. Stanford's 3-D fusion i...New strategy rapidly identifies cancer targets
...viously unknown genetic mutations that can trigger cancerous growth. By analyzing the proteins instead of the genes inside acute myeloid leukemia (AML) cells, the researchers have dramatically reduced the time it takes to zero in on molecular abnormalities that might be vulnerable to specific drug treatments...U of M researchers discover genetic key to treating deadly fungal infections
...al treatment." Berman also explained that some cancerous tumors contain isochromosomes, which means that the finding may yield clues about how some tumors become resistant to chemotherapy and how researchers can develop companion drugs that inhibit the development of that resistance. About 25,000 Ameri...Sunnybrook researchers identify which sets of molecules are required to induce T cells
...n that gamma-delta T cell injections can eliminate cancerous tumours, although much work remains to translate this research into viable clinical therapy. Ziga-Pflcker was recently identified by the prestigious Thomson Scientific Essential Science Indicators as one of the most cited researchers in the field o...Nanotechnology enables low-dose treatment of atherosclerotic plaques
...ct of fumagillin nanoparticles in the treatment of cancerous tumors. According to Winter, the use of inhibitors of blood vessel growth is a well-accepted therapy for cancer, suggesting the nanotechnology may prove beneficial in cancer therapy. Winter PM, Neubauer AM, Caruthers SD, Harris TD, Robertson JD, Will...Penn researchers find role for microRNAs in angiogenesis
...technology to screen MYC-positive and MYC-negative cancerous cells for the presence or absence of 192 known pro- and anti-angiogenesis molecules. They found that, while MYC did not lead to excessive amounts of pro-angiogenesis molecules, it did seem to depopulate an entire family of anti-angiogenesis molecule...Hunt for DNA amplified in cancers uncovers important target gene
...ys that drive the conversion of a normal cell to a cancerous one." says senior author Daniel Haber, MD, PhD, th...cells to grow in soft agar, an assay that measures cancerous potential. Parallel to Overholtzer and colleague's work, the lab of Scott Lowe, PhD, of Cold Spring ...Failure of 'scout cells' may lead to cancer in transplant patients
...ells are re-stimulated properly, they can kill the cancerous cells before PTLD develops, VanBuskirk says. But if that re-stimulation is weak or is blocked, not all of the cells are destroyed and cancer can develop. So it is critical that these two cell types work together effectively. The present study sugg...Rapamycin shown to inhibit angiogenesis
...he leaky, misshapen vasculature that characterizes cancerous tumors. The findings, published in the August 2006 issue of Cancer Cell, additionally demonstrate that rapamycin, a compound used for immunosuppression in transplant patients and currently under investigation as a cancer treatment, can successfully...New company will seek drugs against diabetes and cancer
...ug that aims to influence one gene responsible for cancerous growth. "With our method, we aren't asking what the target is -- we're letting the system tell us," Cagan says. "We're just asking for the bottom line. Do the flies get better? If you find the magic compound that hits everything that contributes t...Cigarette smoke blocks cell repair mechanism, University of Florida study shows
...a. -- Cigarette smoke can turn normal breast cells cancerous by blocking their ability to repair themselves, eventually triggering tumor development, University of Florida scientists report. While some cells nonetheless rally and are able to fix their damaged DNA, many others become unable to access their ow...Jefferson scientists explain cancer cell metabolism changes
... should be able to target that change and kill the cancerous cells." He explains that specialists can image tum...t allows us to develop therapies selective for the cancerous cells only," says Dr. Pestell. ...Researchers map out networks that determine cell fate
...in which a persistent mixed lineage seems to drive cancerous proliferation. Although the researchers worked only with blood-forming stem cells, they suspect that the same basic regulatory principles govern cell type determination in other tissues such as skin, brain and intestine. "We see elements of this f...Molecular motor helps cells tell which way is up
... top and bottom is often lost in cells that become cancerous and may be an important factor in metastasis. Cells depend on the location of a number of proteins and lipids to recognize and maintain their polarity. Moving these lipids and proteins from where they are produced to where they are needed is a dynam...Unusual three-drug combo inhibits growth of aggressive tumors
...e substances might drive the special metabolism of cancerous cells. Investigating experimental mice that develop metastatic tumors of the prostate's neuroendocrine cells, the researchers discovered that the tumor cells relied on molecules that transmit signals between neurons. They found that the tumor cells ...Genome code cracked for breast and colon cancers
... coding errors that transform a normal cell into a cancerous one. To locate the altered nucleotides, the scientists compared the genetic code of their tumor samples with normal ones. First, they used the Human Genome Project (HGP) to identify the sequences of best-known genes more than 13,000 in all roug...Vitamin D may cut pancreatic cancer risk by nearly half
...stablished by other laboratory studies. Normal and cancerous pancreas tissue contain high levels of the enzyme that converts circulating 25-hydroxyvitamin D into 1,25-dihydroxyvitamin D, the vitamin's active form. Other studies have shown an anti-cell proliferation effect of 1,25-dihydroxyvitamin D, potential...Sensitive and specific biomarker for early detection of prostate cancer identified
...itive to cancer. High PSA levels are found in both cancerous and healthy tissue, particularly in benign prostate disease, resulting in significant numbers of false positive cases. The DRE, based on physician touch and skill, relies on subjective judgment. As a result, a man who has prostate cancer can have bot...National Institutes of Health to map genomic changes of lung, brain and ovarian cancers
..., store, process, and distribute biomolecules from cancerous and normal samples to the Cancer Genome Characterization Centers and Genome Sequencing Centers for genomic analysis. TCGA's Cancer Genome Characterization Centers will analyze samples from the BCR to identify key genomic alterations, such as copy ...