Potential diagnostic marker indicates effectiveness of anti-angiogenic drugs
...struct blood vessels including those that feed the cancerous tumor. "For a cancer to survive, grow and spread, a tumor needs to make more endothelial cells and construct new blood vessels to provide oxygen and other nutrients," said NCI scientist Haiqing Li, Ph.D., first author of the study. "In addition to...Structure determined for key molecular complex involved in long-term gene storage
...e is crucial to the distinction between normal and cancerous cells and may inform our ability to treat this disease." The molecular complex studied by the scientists governs the assembly of an especially condensed form of chromatin, the substructure of chromosomes. The complex is called a histone chaperone co...New target for cancer therapy identified
...lomerase also plays a key role in the formation of cancerous tumours. "It's the best indicator of cancer 85 per cent better than any other tumour marker," Associate Professor Liu said. "What's more, telomerase is not associated with benign tumours; it's a marker for malignant tumours only. "If we can control...Natural anti-viral enzyme helps keep cancer cells alive, researchers find
...esponse is stimulated but was always active in the cancerous cells they studied. When they blocked the function of TBK-1 in both the cancerous and healthy cells, cancer cells died while healthy cells survived. A German research team has studie...Images develop clinical applications for new DESI technology
... aid surgeons in precisely and completely removing cancerous tissue," he said. "With these images, we can see the exact location of tumor masses and can detect cancerous sites that are indistinguishable to the naked eye." Current surgical methods rely on the trained ey...Intrinsic eye protein halts angiogenesis
...blood vessel growth, is what propels the growth of cancerous tumors and blinding conditions like macular degeneration. Because healthy corneas are avascular (free of blood vessels) they have long been the testing grounds for anti-angiogenesis drugs intended to treat conditions in other areas of the body. The ...HYPER-CEST MRI breaks new ground in molecular imaging
...) concentrations. The sooner that the presence of cancerous cells is detected, the better the chances are for successful treatment. In addition to high sensitivity and target specificity, HYPER-CEST MRI is also unique from other molecular imaging techniques in that it provides both spatial and biochemical in...HFI-1 gene has key role in both oxygen sensing, heat shock pathway
...could prove beneficial in turning away oxygen from cancerous cells, choking them off by not allowing oxygen in, Johnson said. The rush of oxygen back into cells after a period of hypoxia also works against wound healing. In healthy cells, the researchers theorize, HIF-1's turning on of heat shock proteins is ...Scientists design a PSA-activated protoxin that kills prostate cancer
... revealed that when the protoxin was injected into cancerous prostate tissue, it had a significant effect. "In the lab, PRX302 produced significant and often complete regression of the prostate cancer. Since the PSA gene is only found in primates and humans, we then injected either 0.35 or 4.1 micrograms as ...Genes offer researchers a 'crystal ball' to help them prevent, diagnose and treat cancer
...of 95 percent (meaning it could correctly identify cancerous lesions) and with a 98 percent specificity (the ability to detect truly negative cases). The researchers are continuing to study, validate, and perfect the assay, and test its ability to identify pancreatic cancer at early, treatable stages. Althou...Exercise, aspirin consumption and childbirth may alter cancer risk
...d in response to inflammation and precancerous and cancerous tissues, and its inhibition has been associated with significant reduction in breast cancer tissue. A few large research studies have also shown a reduction in risk of breast cancer among NSAID users. While COX-2 research has found a promising as...Thyroid cancer discovery points to new treatments, prevention
...ated RET protein implicated in a condition causing cancerous thyroid tumours. The model allowed him to predict and compare the protein's molecular actions and to see that the protein was ten times more active than normal in cells associated with Multiple Endocrine Neoplasia 2B (MEN 2B) syndrome, an inherited c...New vaccine stimulates colorectal cancer patient's immune systems to fight cancerous cells
...olorectal cancer patients' immune systems to fight cancerous cells. In a clinical trial of 67 patients, resear...re administered before and after surgery to remove cancerous tumors, they helped stimulated immune cell production in up to 70 percent of patients. These results...JCI table of contents: November 16, 2006
...which constantly active ALK causes cells to become cancerous and to survive long-term are not known. Now, in a ...roteins that are required for ALCL cells to become cancerous and/or to survive long-term. Giorgio Inghirami and colleagues analyzed the genes expressed in ALCL c...Team at CNSE and Einstein receive grant to develop world's smallest cancer detection device
...a next-generation microchip that, when placed in a cancerous mass, can gather information on the presence of metastatic cells that would demand more aggressive cancer therapy. "By integrating cutting-edge science and engineering at the nanoscale level with vital biomedical research, it is our intent to provid...NCI funds Einstein and U. Albany NanoCollege to make world's smallest cancer detection device
...a next-generation microchip that, when placed in a cancerous mass, can gather information on the presence of metastatic cells that would demand more aggressive cancer therapy. "The NCI has placed a very high priority on understanding the 'dialogue' in tumor microenvironments that appears crucial for causing ......ering the DNA. Abnormal methylation patterns in cancerous cells were discovered more than 20 years ago. Yet tumor cells have so many things wrong with them, including methylation abnormalities, that a precise cause-and-effect relationship between cancer and epigenetic alterations has been difficult to pin d...First familial pancreatic cancer gene identified
...ate genes and compared normal pancreas tissue with cancerous pancreas (both from a Family X member and from unr...f palladin RNA in an independent set of normal and cancerous pancreatic samples, and in precancerous pancreatic tissue taken from family X members. This analysis...University of Washington-led team discovers a gene that causes familial pancreatic cancer
...lace and basically to behave," said Brentnall. "In cancerous cells, the cytoskeleton doesn't work correctly, an... were over-expressed in abnormal pre-cancerous and cancerous tissue. "We finally found what we had so doggedly pursued -- a gene that was expressed 21 times more...Researchers find stem-cell therapy effective in targeting metastatic cancer
.... Most chemotherapy drugs affect both normal and cancerous tissue, which is why they also are toxic to naturally fast-growing cells in the body such as hair follicles and intestinal cells. Aboody and her colleagues have developed a two-part system to infiltrate metastatic tumor sites, and then activate a che...