Penn receives grant for initiative to help understand genes' effects on medications
...f drug and device studies. His research focuses on cardiac pharmacoepidemiology, with a particular interest in the effects and proper use of drugs and devices for patients with coronary artery disease. This release can also be found at: www.uphs.upenn.edu/news...Good news: As you age, leg blood vessels adapt so you can still exercise without fainting
... compensatory mechanism for their reduced level of cardiac output during exercise," they reported. In other w...rhaps as a compensation for their reduced level of cardiac output. This indicates that the balance between vasodilation and vasoconstriction in exercising mus...Most promising clinical uses for stem cells from fat agreed on by international society
...nt blood supply, and for treating acute or chronic cardiac and peripheral vascular diseases. Moreover, the group felt the best use of the technology should be to develop therapies using patients' own cells, as opposed to cells that might be donated by other individuals. Because adipose is both abundantly...Embryonic stem cells correct congenital heart defect in mouse embryos
...rotein, called Id "knock-out" mice, display severe cardiac defects and die at mid-gestation. "In this curren... mother can cross the placenta and influence fetal cardiac development in the Id knock-out embryo. The Id knock-out embryos were born, but with partial rescue ...Flies have morning and evening clocks
...eping and waking, fluid balance, body temperature, cardiac output, and oxygen consumption. In the fruit fly Drosophila, however, the circadian clock has its most overt effect on the fly's level of activity. In both flies and humans, the clocks are circuits of neurons that naturally oscillate with a circad...Fat buildup found in hearts of obese or diabetic heart failure patients
...r hearts and greater molecular evidence of haywire cardiac metabolism, a research team led by cardiologists a...oxic heart, which has been shown to cause improper cardiac contraction in the rodents, said first author Saumya Sharma, M.D., a cardiology fellow and researche...Pediatric cardiology researchers describe findings in neurologic outcomes, heart devices
...Ds) are known to be effective in preventing sudden cardiac death in patients who have previously survived cardiac arrest. Researchers from Children's Hospital found that ICDs were equally effective in preventing su...Duchenne Muscular Dystrophy research focuses on early mechanisms
... aspects of neuromuscular system, and skeletal and cardiac muscle. This research impacts all Virginians and helps the College enhance the quality of life for all."...New gene therapy promising for treating Fabry disease
...ng vessel walls, causing constriction. Eventually, cardiac disease, kidney disease or strokes result. "Patients with Fabry disease either don't make enough of the enzyme alpha-galactosidase A or improper synthesis means the enzyme isn't active enough," says Jeffrey Medin, a U of T associate professor in the...Novel AT2R gene transfer prevents hypertension-related enlarged heart, cardiac fibrosis
...e angiotensin II type 2 receptor (AT2R) influences cardiac hypertrophy (enlargement) and myocardial and periv...ndicators However, when protected by AT2R through cardiac transduction LVWT was 85% lower, HW/BW was 91% and myocardial fibrosis was 43% lower after a two-wee...Thyroid treatment can trigger homeland security detectors
...rocedures, including FDG PET scans, bone scans and cardiac scans, can have a similar effect, although for shorter periods. "The nuclear medicine community has been aware that patients set off detectors, but now we expect it to become a more common occurrence with the increasing number of extremely sensiti...JCI table of contents, December 1 2004
...tem cells are able to home to injured skeletal and cardiac muscle, however in the past, marker proteins that ...hese stem cells would be recruited to skeletal and cardiac muscle to restore delta -sarcoglycan expression. Surprisingly, upon examination of many thousands of...Salt-water minnow research helps explain human cardiology
...Those differences explain much of the variation in cardiac metabolism of both sugar and fat, the researchers ...some of us can eat fatty foods and not suffer from cardiac disease," said Crawford, "and why some drugs or medical treatments work on some individuals but not ...Exercise doesn't work for us all
...mprovement at all. Similar patterns were seen with cardiac output, blood pressure, heart rate and other markers of fitness. Bouchard reported that the impact of training on insulin sensitivity- a marker of risk for diabetes and heart disease- also varied. It improved in 58 per cent of the volunteers followi...New system reduces risk of burns during interventional X-rays
...onary angioplasty, stent placement, radiofrequency cardiac ablation and vascular embolization. "With the equipment that currently is being used, the physician can minimize the chance for burns by moving the X-ray source instead of keeping the intensity on one spot," explained Darold Wobschall, Ph.D.,...Red wine lovers, take heart: More evidence points to the drink's cardiac heath benefits
...ssue by limiting the effects of a condition called cardiac fibrosis. Diseases such as hypertension and heart ...sue. This condition arises when heart cells called cardiac fibroblasts are activated. These cells secrete collagen, a protein that provides structural support ...MIT team aims to mend broken hearts
...ssue that displays many of the hallmarks of mature cardiac tissue, including regular contractions. "We have ...eart," she said. The MIT approach involves seeding cardiac cells, in this case from a rat, onto a 3D polymer scaffold that slowly biodegrades as the cells deve...Body's biological clock found to affect cardiac rhythm patterns in healthy adults
...a.m., the time of day most often linked to adverse cardiac events in individuals with heart disease. The BU...d statistical physics methods to investigations of cardiac dynamics, probing for hidden patterns. Previous statistical evaluations of heartbeat fluctuations b...JCI table of contents, 3 January 2005
...e been deprived of vital oxygen, such as angina or cardiac arrest. TITLE: Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. AUTHOR CONTACT:Peter Carmeliet Center for Transgene Technology and Gene Therapy, Leuven, Belgium. Phone: 32-1......ll School of Medicine have shown that a protein in cardiac muscle cells may play a crucial role in heart fail... muscle-specific RING finger 1, and helps regulate cardiac cellular molecules involved in abnormal enlargement of the heart. This condition, known medically as...