JCI table of contents May 2, 2005
...The researchers find that affected individuals and carriers of the disease in a large family had a mutation in...infects T cells. Most individuals remain lifelong carriers without any symptoms, but 2-3% of infected people develop adult T cell leukemia (ATL) and another sm...Washington University chosen as NIH Program of Excellence in Nanotechnology
...r Craig Hawker (UC-Santa Barbara), will be used as carriers for diagnostic imaging agents and also therapeutics. Add a protective agent and then a permeation peptide that allows entry into cells, and the nanomaterial becomes more sophisticated. Incorporated into the nanoparticle will be a chelater that w...A human parasite with a streamlined mitochondrion
...ent specialized versions. In humans, these diverse carriers are needed to import and export the varied chemicals required, or produced, by our complex mitochondria. The presence of a single carrier in the Entamoeba mitosome means that it must be able to do far fewer jobs than our own mitochondria. Further exp...UCLA researchers discover new method to generate human bone
...other clinical applications, we will need moldable carriers that can hold the UCB in place better. By making l... that may assist in the development of appropriate carriers for UCB. The Musculoskeletal Transplant Foundation, the nation's largest tissue bank, has signed a ...African-American women less likely to undergo genetic testing than white women
...ill remain unrealized for the majority of mutation carriers until efforts are increased to define and bridge the racial, ethnic, economic, and knowledge-based disparities that contribute to the unequal access and utilization of preventive medical services. Only by improving the ability to recognize and define...SSRI antidepressants involve dopamine as well as serotonin signaling
...ke by inhibiting the action of the molecular cargo carriers called transporters that recycle serotonin back to the neuronal storage sacs called vesicles. Now, however, Fu-Ming Zhou (presently at the University of Tennessee) and colleagues at Baylor College of Medicine have revealed that SSRIs can have more co...BRCA1 causes ovarian cancer through indirect, biochemical route
...ll-known breast cancer gene, BRCA1, not only gives carriers of its mutated form a four in five chance of developing breast cancer, it also confers a 40 percent risk of developing ovarian cancer by the age of 70. How that risk is imparted, however, had been harder to pin down. "We've known for a long time that...Antioxidant blood levels key to MnSOD gene
...arly sensitive to oxidative stress. Conversely, if carriers of this genetic variant have low levels of these v...idants in their blood. Compared to MnSOD VV or VA carriers with low selenium those men in the lowest quartile of the study group MnSOD AA males had an 89 per...Histamine, anxiety and alcoholism
...more abundant among nonalcoholics, suggesting that carriers of the Ile105 allele might be protected against the development of alcoholism. Since harm avoidance was also lower among nonalcoholics, it would appear that the protective effect of the Ile105 allele against alcoholism is mediated by lower harm avoi...UCLA scientists store materials in cells' natural vaults
...s likely to elicit an immune response than foreign carriers like viruses. IMPACT: The UCLA discovery will enable many potential applications, including: Therapeutic delivery, such as homing cancer drugs directly to a tumor cell without harming healthy tissue Enzyme delivery to replace missing or defect...Georgia Tech research indicates immune complications associated with combination medical devices
...ic cell maturation may be best suited as polymeric carriers for vaccine delivery and those that do not support dendritic cell maturation may be used as sponges in tissue engineering. "It seems that there may be a way to control the immune response to a biological component through the use of different bioma...Tips from the Journals of the American Society for Microbiology
...rnal Applied and Environmental Microbiology. Known carriers of viral and bacterial pathogens, seafood and shellfish accounted for 7.42% of food poisoning related deaths attributed to Salmonella between 1990 and 1998. Characterized by fever, abdominal cramps, and diarrhea, salmonellosis is responsible for app...Novel sulfide-binding mechanism found in deep-sea tubeworms
..., including as an artificial substitute for oxygen carriers in human blood. Tubeworms living near hydrothermal...nal hemoglobins as possible substitutes for oxygen carriers in human blood. "The newly characterized molecule is substantially smaller than the hexagonal hemog...Certain genetic test helps detect mutations that may be missed by conventional DNA test
...ion and interpretation of mismatch repair mutation carriers is essential for clinical management of colorectal cancer patients and for scientific studies in which the mutation status of participants is an important variable. Currently, most genetic testing is performed by genomic DNA sequence analysis, but ce...Removing prions that cause mad cow in humans from blood
...cteristic poses the key question: How many dormant carriers of vCJD are out there who are at risk of developing clinical disease and who also may be blood donors? There is currently a ban on blood donations from people who lived in countries with bovine spongiform encephalopathy (BSE) infected cattle, which...Mutations in transporter protein shed light on neurodegenerative disorders
...ced activity. From the work of others we know that carriers are asymptomatic even with a 50 percent reduction in sialic acid transport activity. This suggests that for the milder form of the disease increasing the level of expression or stability of the protein could be one way to treat the disease," conclude...Yo-yo diet redistributes toxins in body tissue; Olestra+caloric cut boosts toxic excretion
... need for future studies into the possible role of carriers of HCB. HCB was cleared more rapidly from chylomi...ds generated during fat metabolism." "How plasma carriers facilitate HCB entry into the brain is an interesting question with potential physiological implicat...Mutant gene linked to treatment-resistant depression
...eria for major depression, the three control group carriers also had family histories of psychiatric problems and experienced mild depression and anxiety symptoms. This points up the complexity of these disorders, say the researchers. For example, major depression is thought to be 40-70 percent heritable, bu...World's largest population study on BRCA1/2
...a population level. Data about the risk in BRCA1/2 carriers are often contradictory, so a population-based data analysis in families eligible for BRCA 1/2 mutation testing may help to establish a consensus about the association of these mutations with cancer at sites other than the breast and ovary. "This stu......ggest the child of a couple where both parents are carriers has a 1:4 chance of developing a severe form of co...om Ontario. Compared to non-carriers, the MYH gene carriers had a higher risk of acquiring colorectal cancer. ...