DNA sequence controls expression of gene involved in cancer
...D - Scientists have discovered a DNA sequence that causes the destabilization, and hence decay, of the protooncogene bcl-2 (B-cell lymphoma/leukemia-2). Because the overexpression of bcl-2 is associated with cancer, this discovery may lead to new therapeutic strategies for treating the disease. The research...Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
...by low bone mass and structural deterioration that causes bones, most commonly of the hip, wrist and spine, to become brittle and susceptible to fracture. Approximately 200 million women worldwide suffer from osteoporosis, according to the International Osteoporosis Foundation. An osteoporosis-related hip...Stanford cooling tool may improve performance of athletes, soldiers
...of the air out of the chamber," he explains. "This causes blood to be pulled into the hand. Then we cool the overlying skin surface of the palm of the hand [by circulating cool water through a closed system on which the palm of the hand rests], which cools the blood in the hand's vascular heat-exchange stru...Research out this week helps us understand basics of how neurons communicate
... cells occurs when calcium enters a nerve cell and causes the cell to release a chemical called a neurotransmitter that then carries a signal to other nerve cells. Calcium cannot freely enter cells, and must wait for an opening of a molecular gate, which is called a calcium channel. "In this study we remove...Protein energy profiles offer clues about amyloids
...wn. The research could support efforts to find the causes for diseases involving amyloids, and it could prove useful for researchers studying proteins involved in even more prevalent diseases like cancer and heart disease. "We know now that most diseases involve proteins going wrong in one of two ways," sai...Biologists ID molecular block for social 'cheaters'
...lls produce a signaling molecule called DIF-1 that causes some members of the colony to differentiate themselves from the rest of the group and enter a prestalk stage of development. Using biotechnology, the research team created a mutant strain of Dictyostelium without the gene dimA, which codes for a key ...Interactive health information system to detect Japanese encephalitis in Asia
...ncephalitis kills one-third of those infected, and causes severe disabilities in half of those who survive. To successfully combat Japanese encephalitis, health officials need surveillance networks that allow them to respond quickly to reported cases and readily identify outbreaks. Voxiva h...Toward a better understanding of taste and smell impairments
...erson CCRC seek to characterize and understand the causes of taste and smell disorders and to develop treatm... the United States and one of the most significant causes of smell loss. Scientists currently have only a limited understanding of how CR impairs olfactory fu...U-M scientists see ubiquitin-modified proteins in living cells
...turned off, that's not normal. Prolonged signaling causes aberrant growth and other problems for the cell." "When ubiquitin is attached to Jun, the complex is transported to the lysosome getting it away from DNA in the nucleus and preventing Jun from continuing its normal gene transcription function,...T cell's memory may offer long-term immunity to leishmaniasis
...an offer immunity to leishmaniasis, a disease that causes considerable death and disfigurement across the globe and has been found in U.S. military personnel returning from Afghanistan and Iraq. In the October issue of Nature Medicine, the Penn researchers describe how the discovery can offer immunity to l...Drought in the West linked to warmer temperatures
... was important to understand some of the long-term causes of drought in North America," said lead author Dr. Edward R. Cook of the Lamont Doherty Earth Observatory's tree ring laboratory. The study revealed that a 400-year-long period of elevated aridity and epic drought occurred in what is now the western ...Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2004
... ]. BUILDINGS -- After the flood . . . Flooding causes more damage to buildings throughout the United States--particularly residential buildings-- than any other single natural event. Researchers at Oak Ridge National Laboratory have found through tests that damage to homes from future flooding can be mi...Environmental exposures before and after birth can harm children's lungs
...eculate how PAH exposure, in conjunction with ETS, causes respiratory damage," said Dr. Miller. "One possibility is that PAHs, which easily reach the fetus and damage DNA, affect the child's developmental programming, which then leaves the child's airways at risk for future harm." People living i...Acoustics meeting in San Diego
...on of animals, in efforts to better understand the causes of the beachings (2pAB8). In another talk at the ...A3) THE CAUSES OF STUTTERING: NEW INSIGHTS What causes stuttering, a condition suffered by an estimated three million people in the U.S. alone? Finding th...Study in Royal Society journals presents evidence for inherited factors in homosexuality
...a, Dr A Camperio-Ciani and Dr C Capiluppi Genetic causes of male homosexuality are often the argument of inflamed discussion. A strong opposition to the genetic explanation is the Darwinian paradox; in fact a genetic factor that reduces reproductive success should progressively disappear from the populatio...Gladstone researchers resolve key Huntington's disease mystery in Nature cover story
...ify the mechanisms by which the huntingtin protein causes Huntington's and may add to the understanding of other neurodegenerative disorders." Traditionally, scientists have tried to illuminate the role of the mutant protein within neurons by taking one-time snapshots of individual cells, a slow process tha...Study using robotic microscope shows how mutant Huntington's protein affects neurons
...contained a version of the huntingtin protein that causes HD. The huntingtin was fused to green fluorescent protein, a widely used marker that allows researchers to see where proteins accumulate. Many neurons with the mutated HD gene died without forming inclusion bodies, the researchers found. The f...Phillip A. Sharp to present 2004 Ullyot Public Affairs Lecture at Chemical Heritage Foundation
...ormation is important in understanding the genetic causes of cancer and other diseases. Sharp's research opened an entirely new area in molecular biology and forever changed the field. For this work he was awarded the 1993 Nobel Prize in Physiology or Medicine. Sharp is cofounder of Biogen (now Biogen Idec...Muscling in on a deadly cancer
...eatment.) Capecchi says the cancer causes tumors in various muscles throughout the body, pri...runs amok in cancer. Researchers believe Pax3:Fkhr causes cancer by triggering inappropriate muscle development. Unraveling the Workings of...Amphibians in dramatic decline; Up to 122 extinct since 1980
...nd water pollution and consumer demand are leading causes of amphibian decline. Still, scientists are confident that an immediate commitment of resources and effort could reverse many of the present negative trends. Creating new protected areas, captive breeding programs, better community engagement and...