Study identifies new gene therapy tools for inherited blindness
...lements that turn on the healthy gene in the right cells and at the right levels." Corbo and colleagues us...ates, photoreceptors are the most energy-intensive cells in the human body, consuming more power than any other cell type. Unfortunately, high energy also br...Call for EU to launch major project to map out all our proteins
...ons, involve disruption to regulatory processes in cells or tissues with associated changes in the abundanc...y rarely or under specific conditions expressed in cells or tissues, or that the mRNA, which is the intermediate product between the DNA of the genome and th...Scratch no more: Gene for itch sensation discovered
...nd in a very small population of spinal cord nerve cells where pain and itch signals are transmitted from t...tood out because it is present in only a few nerve cells in the spinal cord known to relay pain and/or itch signals to the brain. So they began to study some...News tips from the Journal of Neuroscience
...olic scavenging also potentially serves to protect cells from the toxic effects of monoamines. In fact, VMAT is a member of the toxin-extruding antiporter gene family with the interesting acronym TEXAN. Accordingly, Caudle et al. examined whether reduced VMAT2 leads to degeneration of dopamine neurons. The...Drug protects brain cells in Huntington's disease model, researchers find
...oms of Huntingtons disease prevents death of brain cells in mice genetically engineered to mimic the heredi...toms appear. The drug can actually prevent brain cells from dying, said Dr. Ilya Bezprozvanny, associate professor of physiology at UT Southwestern. Its mu...CTRC enrolls first patients in novel phase II study for sarcoma -- living virus destroys cancer cell
..., not a chemotherapy drug, that is toxic to cancer cells but not harmful to normal cells. This novel thera...the reovirus replicates in and destroys the cancer cells within the patients body, said Mita. Cancer cells have several molecular and genetic abnormalities....Monell researchers find metabolic defect in liver that can lead to obesity
...burn fat. Fat is one of the fuels that the bodys cells burn to provide energy. This process, known as fat oxidation, takes place inside mitochondria, the cells power plants for generating energy. If the ability to oxidize fat is impaired, the bodys capacit...Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
...ury combining radiation therapy to destroy harmful cells and microsurgery to drain excess fluids significan...efforts during the second or third week by certain cells that block the repair process. In earlier research on rats with cords that were completely sever...Enzyme discovery sheds light on vitamin D
...ography mass spectrometry, the researchers studied cells from animals in both categories. They changed the human enzyme in certain key places to see if this would affect its pathway pattern. Surprisingly, they discovered that altering a single amino acid completely changes the enzyme from a human pattern...Faster-acting antidepressants closer to becoming a reality
..., one of the chemical messengers that enable brain cells to communicate with each other. The glutamate system has been implicated in depression recently, leading to efforts to unravel its molecular machinery in search of abnormalities and of better targets for antidepressant medications. This focus on t...American Chemical Society's Weekly PressPac -- July 18, 2007
...g In This Edition: Toward giving artificial cells the ability to move Nano-sized generator gets big...FOR IMMEDIATE RELEASE Toward giving artificial cells the ability to move Journal of the American Chemical Society Got legs" Chemists in Japan and It...UB scientist discovers novel iron-copper alliance
...chemistry, discovered that when iron-absorption by cells lining the small intestine decreases during iron-deficient states, copper absorption increases. Collins now is exploring the relationship between these two trace minerals through a $1.38 million grant from the National Institute of Diabetes and Diges...Effects of aging in stem cells
...as there is plenty of disagreement as to why. Stem cells combat the aging process by replenishing old or da...generative capacity also declines with age as stem cells acquire functional defects. Stuart Chambers, Margaret Goodell, and their colleagues investigated...A novel molecular dictator 'with a conscience' discovered
...urally occurring mechanism in the body where "bad" cells that cause blockages in our blood vessels are kept under strict growth control, while "good" cells that keep our blood vessels free of clots and growths are left unaffected. The discovery is expect...Identified main genetic variants involved in response to HIV
...e system so that it is able to locate and destroys cells infected by HIV. This study has also identified a third genetic variation involved in immune damage of patients, particularly in a gene encoding a protein which seemingly participates in viral replication, and is also located in chromosome 6. Genet...'Preconditioning' helps protect brain's blood vessels from stroke
...y use today. And we know it can help protect brain cells -- neurons -- against stroke damage," Dr. Iadecola...oxious stimulus beforehand -- can strengthen brain cells against damage from a larger insult later on. This phenomenon occurs naturally in the human brain," ...Genomic analysis uncovers new targets for HIV vaccine
...s with specific gene variants in key immune system cells appear to be much better at controlling the proliferation of the virus after infection. These gene variants are known as polymorphisms. These results not only approximately double our understanding of the factors that influence variation amongst in...New clue into how diet and exercise enhance longevity
... pathway governs growth and metabolic processes in cells throughout the body. The pathway is activated when... Mice lacking one copy of the Irs2 gene in brain cells also showed an 18 percent longer lifespan, and the near complete deletion of brain Irs2 had a simi...Molecular detectors may refine cancer treatment
...ar probes to detect subtle differences in leukemia cells from patient samples, an achievement that could le.... UF scientists designed the aptamers to bind to cells and molecules associated with leukemia, a cancer of the blood and bone marrow that annually claims a...... was able to enter the gastrointestinal epithelial cells lining the gut of both Muc1-deficient and Muc1-intact mice, intestinal damage was more common in Muc1-deficient animals, and the authors determined that the prevention of the spread of infection was exclusively due to Muc1 on the surface of gut epith...