American Chemical Society's Weekly PressPac -- Aug. 8, 2007
...at luminescent silica nanoparticles did not damage cellular DNA. Our study indicates that the luminescent silica nanoparticle is a promising labeling reagent for various biomedical applications, the study concluded, citing the need for further research on potential long-term toxicity. ARTICLE #2 FOR IMMEDI...Unravelling new complexity in the genome
...re complex life forms. Increased functional and cellular complexity can be explained, in large part, by how genes and the products of genes are regulated. A University of Toronto-led study published in the latest issue of Genome Biology reveals that a step in gene expression (referred to as alternative spl...Doernbecher Children's Hospital scientist earns coveted Javits award
...e and Stroke (NINDS) for his pioneering workin the cellular and molecular cause(s) of brain injury in prematureinfants. NINDS is a branch of the National Institutes of Health. "I am thrilled the NINDS continues to recognize the potential of theunique research models we have developed - some of which are not...Gene regulation, not just genes, is what sets humans apart
...are relatively simple to break down and convert to cellular fuel. Humans, on the other hand, eat a wider array of foods, including many the chimps would simply not be able to digest like starchy root crops. The researchers found dramatic differences in the regulatory regions of their genes for breaking down m...MIT creates 3-D images of living cell
...re that you haven't somehow interfered with normal cellular function, said Badizadegan. The current resolution of the new technique is about 500 nanometers, or billionths of a meter, but the team is working on improving the resolution. We are confident that we can attain 150 nanometers, and perhaps higher r...Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
...ncer-causing molecules that would otherwise damage cellular DNA, thus rendering them inert. They actually convert known carcinogens to non-toxic chemicals, and studies have shown a correlation between deficient expression of these enzymes and increased risk of developing some cancers, Chow said. Expres...New, more direct pathways from outside the cell-to-cell nuclei discovered
... enormous impact on how scientists think about how cellular functions are regulated." Gavin has only observe...beads. Similarly, the researchers also labeled the cellular membrane with a fluorescent dye, and then observed the pinched off, internalized membrane move to th...Abnormal fat metabolism underlies heart problems in diabetic patients
...ells of diabetic mice lose an important lipid from cellular components that generate energy for the heart, and...membranes causing abnormal physical properties and cellular dysfunction." The important lipid that the researchers found to be decreased in diabetes is cardioli...ESF EURYI award winner aims to stop cancer cells reading their own DNA
...variety of diseases involving disruption to normal cellular functions and not just cancer. Dekkers work has a...le experiments have resulted in a prediction for a cellular effect, said Dekker. ...Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
... able to attach itself to a chaperone, an abundant cellular protein that helps other proteins to fold properly. These new compounds can tether bulky chaperones to the beta-amyloid fragments and prevent them from forming large clumps. As a result, these molecules are effective at reducing protein clumping at c...Antioxidant overload may underlie a heritable human disease
...ntegral to the release and storage of energy. Many cellular pathways are also sensitive to the prevailing redox condition. Oxidative stress, which consumes reducing equivalents, has been often implicated in numerous cardiac and other diseases, Benjamin noted. However, the possibility remained that an invers...JCI table of contents: Aug. 9, 2007
...ndrial-dependent necrotic cardiomyocyte death is a cellular event that contributes to heart failure in mice, l...lecular pathways that control feeding behavior and cellular energy expenditure are highly complex and not completely understood. In a study that appears onlin...European Science Foundation's Forward Look reaches out beyond the endless frontiers
...e.g. closing the gap between the molecular and the cellular technologies and the clinical diagnostic nanotechnologies Recommendations on organization and funding of Nanomedicine-related research activities Proactive risk assessment for nanomaterials needed Recommendations on commercial expl...Female gender provides an advantage in renal diseases
...enal injury. Estrogen especially may exert certain cellular effects on the kidney because it can suppress the growth of scar tissue as well as affect various growth factors which impact the kidney. Research Update: Estrogen in Renal Disease Previous studies using animal models have used hormonal manipu...Research aims to identify markers for menopausal women at risk for deadly blood clot
...Women The study focuses on platelets, which are cellular fragments in the blood. Platelets have a phenotype (i.e., a set of physical characteristics) that change and it is known that hormones affect platelet change. The team is examining what happens to platelets in the presence of hormones whether platel...Weizmann Institute scientists discover a control mechanism for metastasis
...cell wall, initiating a sequence of changes in the cellular structure. The cells internal skeleton an assembly of densely-packed protein fibers comes apart and the protein fibers then form thin threads on the outside of the cell membrane that push the cell away from its neighbors. In addition, a number of p...Role of thyroid hormones in slumber under investigation at Rutgers
...ted from a gland located in the neck and increases cellular activity in nearly all tissues of the body by acting inside cells. Thyroid hormones do so much more than regulate weight. Were really just beginning to learn the true extent of how these hormones impact our overall health, Martin says. The rese...Penn researchers discover how key protein stops inflammation
...intracellular system of checks and balances, where cellular proteins are flagged for disposal. During exposure to infection, Bcl-3 appears to overrule the p50 ubiquitination, stabilizing the presence of p50 on DNA and halting inflammation. Our study identifies another layer of information that controls the ...UCLA scientists produce functioning neurons from human embryonic stem cells
...e synapse network. We will be able to study the cellular properties of neurons in a very defined way that will maybe tell us what goes wrong in diseases such as Alzheimers and Parkinsons, Sun said. Were currently creating many models of human neurological diseases that may provide the answers were looking ...In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
...molecules of messenger RNA forms the basis of all cellular activities. Yet little is known about the dynamics of the process how efficient it is or how long it takes. Now, researchers at the Albert Einstein College of Medicine of Yeshiva University have measured the stages of transcription in real time. The...