Childhood deficits in the cerebellum may be linked to adult alcoholism
The brain's cerebellum is key to the body's coordination of movement. Ne...ing can also cause progressive degeneration of the cerebellum for some alcoholics. Defects in the cerebellum itself, however, have never been considered as a pot...Mosaic mouse technique offers a powerful new tool to study diseases and genetics
... researchers used MADM to study the development of cerebellum granule cells, which are the most abundant cells i...f mice and humans. "Usually people think that all cerebellum granule cells are the same--they are born, and their final function is determined by their interacti...Study strengthens link between Foxp2 gene and language development
...he maturation of neurons in the development of the cerebellum (the part of the brain responsible for the coordin...ermine which genes are abnormally expressed in the cerebellum in these animals," says Dr. Buxbaum. "Those genes might be legitimate autism-susceptibility genes."...Human cerebellum and cortex age in very different ways
...ellows. "The fact that gene activity levels in the cerebellum remain more stable as a person ages suggests that ... and consistent. Changes in gene expression in the cerebellum were smaller and less coordinated. The study by Plotkin, Eisen, Berkeley graduate student Hunter B. ...Gene expression in the aging brain
...ndreds of genes. Only one non-cortical region, the cerebellum (whose principal functions include movement), showed little change in age-related gene expression. Intriguingly, the set of affected cortical genes was different between humans and chimps. Since humans and chimps diverged about 5 million years ago - ...Understanding Fragile X syndrome with the blink of an eye
...gation of the role of abnormalities in the brain's cerebellum in Fragile X syndrome. Fragile X syndrome is cause...n motor learning and the effects on neurons in the cerebellum of knocking out this gene. They found that mice lacking the gene showed deficits in a particular mot...Cerebellum found to be important in cognition and behavior
...al Boston is documenting an important role for the cerebellum previously thought to be principally involved in ...ediatrics, also demonstrates that the cerebrum and cerebellum are tightly interconnected. Sophisticated MRI imaging of 74 preterm infants' brains revealed that w...Experiencing the world through the neurons of Math1
...air cells in the inner ear and some neurons in the cerebellum and intestine. Now, mouse studies carried out by her and two graduate students, Matthew Rose and Vincent Y. Wang, demonstrate that Math1 plays a pivotal role in the formation of many of the neurons important in carrying hearing and vestib...Any way you splice it: FGF8 in development
...us. However, only FGF8b can transform midbrain to cerebellum whereas FGF8a causes an overgrowth of midbrain. Dr. Moosa Mohammadi's research team has solved the crystal structure of FGF8b in complex with the FGFR2c receptor, and shows that additional contacts between a single amino acid from the alternatively s...Mutation in brain cells of descendants of Abraham Lincoln suggest he suffered from movement disorder
...hich disrupts the ability of certain nerves in the cerebellum to respond normally to incoming chemical signals. Eventually, these nerves -- called Purkinje cells -- degenerate, and the person loses fine control of the leg and arm muscles. This would explain historical descriptions of Lincoln's uneven gait -- an......fish reared in tanks, but the relative size of the cerebellum compared to the rest of the brain was about the same as in fish reared in tanks with stones....Unraveling Alzheimer's: Clues may be found visualizing plaques in human brain, mad cowtype diseases
... in the cortex, colliculus, hippocampus, thalamus, cerebellum and pons. "Additional work needs to focus on the progression of disease in our animal model in vivo, and we must correlate the images with clinical symptoms," he added. ...Genetic parallels found between lung development and lung cancer
...stoma shares many common genetic features with the cerebellum in its earliest stages of development ( www.childrenshospital.org/newsroom/Site1339/mainpageS1339P1sublevel81.html ). ...News tips from the Journal of Neuroscience
...llum Reinhard W. Kster and Scott E. Fraser The cerebellum arises from the anterior hindbrain according to si...t the anteroventral base of rhombomere 1. When the cerebellum was ablated at 36 h after fertilization, GFP-labeled cells regenerated within a few days, and the fi...News tips from the Journal of Neuroscience
...4) is an unusual beast. Expressed predominantly in cerebellum Purkinje cells rather than glia, the molecule also functions as an anion-selective ion channel. The current model for transport is that a molecule of glutamate is transported independently by each subunit in the homotrimeric transporter. The crystal ...Untangling a pathology of Alzheimer's
... found higher levels of PSA gene expression in the cerebellum than in the cortex of patients with such diseases....ion in samples of brain tissue from the cortex and cerebellum of both normal humans and those with fibrillary tangle disorders. In both types of samples, they fou...Animals resistant to drunken behavior offer clues to alcoholism's roots
...the brain, and specifically to the cerebellum. The cerebellum is responsible for coordinating fine muscle movements and maintaining balance and is known to play a role in the loss of coordination characteristic of drunkenness. Indeed, the researchers found, their mutant mice were resistant to the "hypnotic an...Gene linked to autism in families with more than one affected child
...nal growth in the cortex and similarly shrinks the cerebellum abnormalities also seen in autism. To explore this possible connection, the researchers looked for associations between the brain disorder and nine markers in the MET gene, sites where letters in the genetic code vary among individuals. They tested...... week, Jahanshahi et al. examined the roles of the cerebellum and basal ganglia in several timing tasks. Using p...time reproduction tasks produced activation in the cerebellum and basal ganglia structures. When the time reproduction tasks were compared with the control tasks,...