New use for a cell toxin found to inhibit survival proteins in cancer cells
...s, so just by over expressing the protein the cell changes so that it cant live without that protein. The next step in this research is to use the assays his lab developed to cast a wider net to find additional compounds that have similar properties to 2-Methoxy antimycin, Hockenbery said. This strategy has...A stepwise retreat: How immune cells catch pathogens
...selves into a system and have to react flexibly to changes within the system. Precisely these properties we have now observed in filopodia retraction. The fascinating principles, which we are beginning to understand, will certainly influence the design of such machines....Modified herpes virus keeps arteries 'free-flowing' following procedures
...erpes simplex virus during angioplasty had minimal changes in the arteries. The smooth muscle cell proliferation which causes the restenosis was very low in the group treated with herpes and remained high in the untreated group. One undesirable, yet expected outcome of angioplasty and stent placement is th...Study provides new data about the laws governing embryo development in organisms
...they divide, their form and their behaviour. These changes are coordinated through a series of instructions that must be correctly interpreted within the cell, and this means that the information must pass along a pathway of signalling molecules. These pathways have been conserved across evolution, and there...Fat horses face health problems
...dative stress, a malady that occurs as a result of changes to metabolic processes that alter the delicate balances between the destruction and creation of new cells in the body. Oxidative stress is an imbalance between the production of free radicals and reactive oxygen species and the bodys anti-oxidant d...A spoonful of sugar helps your waistline go down
...p combining the sugar-containing diet and activity changes recorded the greatest positive health outcomes, compared with diet or exercise alone. Significant reductions were observed in body weight (4.7% loss), waist circumference and percentage body fat. Measures of blood fats (total cholesterol and LDL) had...Neutral evolution has helped shape our genome
...he genetic bits and pieces that drive evolutionary changes do not confer any advantages or disadvantages to h...ic belief of evolution was that all random genetic changes that manage to stick around have some selective advantage, says Nicholas Katsanis, Ph.D., Associate ...Loss of hemlocks will affect water dynamics in southern Appalachian forests
... leader. With the loss of this species, we predict changes to streamflow, streamside forest structure, and so...t and timing of stream flow. The duration of these changes will depend on how other vegetation responds to the loss of hemlock. ...It don't mean a thing if it ain't got that (modern) swing
...is learned, it takes on regional variations and it changes with time. For the remainder of her doctorate thesis, Derryberry is studying song styles in 15 populations of white-crowned sparrows from Washington to California. Interestingly, many of the regional songs are changing in the same direction, with ...Internal clock, external light regulate plant growth
Most plants and animals show changes in activity over a 24-hour cycle. Now, for the first time, researchers have shown how a plant combines signals from its internal clock with those from the environment to show a daily rhythm of growth. Using time-lapse photography, postdoctoral rese...Tiny tweezers and yeast help St. Jude show how cancer drug works
... used the microscopic magnetic tweezers to monitor changes in the length of an individual DNA molecule caused by the action of a single topoisomerase I enzyme; and to study how the binding of a single topotecan molecule to this enzyme-DNA complex alters DNA uncoiling. Based on the results of those studies, s...Size and positioning of floral anthers facilitates pollen collection by bees
...ry sequences that do not encode proteins. Slight changes in these networks or in the non-coding sequences can change the developmental pattern of a flower and thus its morphologyeither dooming it if its pollinators can no longer fit properly or guaranteeing the success of the species if it acquires new pol...Size and positioning of floral anthers facilitates
...tory sequences that do not encode proteins. Slight changes in these networks or in the non-coding sequences can change the developmental pattern of a flower and thus its morphologyeither dooming it if its pollinators can no longer fit properly or guaranteeing the success of the species if it acquires new pol...A gene that protects from kidney disease
...numbers of kidney cells die. The organ shrinks and changes in its architecture occur which affect normal kidney function. To find out if GLIS2 has the same effect in humans Friedhelm Hildebrandt and his team at the University of Michigan carried out a genetic screen of patients suffering from NPHP. They fo...Specific type of cell death may accelerate decompensated heart failure
...ular disease, autophagy might also lead to harmful changes in the heart muscle, particularly in decompensated heart failure an inability of the muscle to function and maintain adequate blood flow, the UT Southwestern researchers reported. In the study, Dr. Hill and his colleagues genetically engineered mi...University of Cincinnati receives $1.7M to research molecular treatment of brain injury
... unable to prevent or manipulate these progressive changes that follow traumatic brain injury. Strauss and other researchers previously found that the enzyme COX-2 is one of the contributors to harmful inflammation. COX-2 increases following injury and, to the brains detriment, remains elevated for many da...Investigating Life in Extreme Environments report gives hints on facts of life
...ong other issues, the report has stated how global changes in the recent decades have turned some environments setting into becoming extreme conditions for the normal ecosystems (e.g. acidification of the oceans). Therefore the understanding of tolerance/adaptation/non-adaptation to extreme conditions and ec...Common environmental chemicals in diet affect fetal ovarian development
...ith those seen in sheep, and investigating whether changes induced in the sheep fetus could be a problem for the developing human. They also intend to look at the mechanisms by which exposure to environmental chemicals can cause defects in reproductive development in order to determine what might be done to ...Link between immune system and mammary gland could shed new light on breast cancer
...ments: The breast undergoes tremendous and amazing changes during and after pregnancy. The body generates milk producing cells using signalling mechanisms adopted from the immune system and once a child is weaned these cells die and the mammary gland returns to its pre-pregnant state. It is vital that we und......yer thickness. As the oil layer thickens, the oil changes its appearance from bright green to bright red. The observed color is neither dependent on the angle of observation nor on the direction or type of light. Secondly, the shift in color is due to the unique characteristics of the cells in the human ...