Tag: "channel" at biology news
A sensory organ, not the brain, differentiates male and female behavior in some mammals
...ngs Xu studied female mice mutant in TRPC2, an ion channel
whose absence disables the vomeronasal organ, which works along with the nose to detect pheromones. They found that these females, when placed in a cage with a sexually experienced male, would engage in typically male courtship activity: chasing th...
Altering a protein makes mice less fearful
...inhibition of a protein, known as acid sensing ion channel
protein (ASIC1a), reduces innate fear behavior in ...se. "Showing that pharmacologically blocking the channel
reduces innate fear behavior, in theory, sets the stage for investigating whether therapies that blo...
Forsyth scientists gain new understanding of adult stem cell regulation
...showed that when one of many specific gap junction channel
types was abolished, the adult stem cell pool disappeared along with the regenerative capabilities, suggesting that gap junction-permeable signals are necessary to maintain stem cell state and tissue regeneration. This research demonstrates a novel r...
News tips from the Journal of Neuroscience
...ty in two ways: by overexpressing a leak potassium channel
or by inhibiting AMPA receptor trafficking. In both cases, there was a compensatory increase in membrane excitability as a result of increased amplitude of voltage-gated sodium currents. From Ribbon Synapses to Spike Trains Peter Heil, Heinric...
Study points to new way to predict death risk from torn aorta
...-imaging scans: the presence of blood clots in the channel
created when the layers of the aorta separate like..., small openings at the bottom of the newly formed channel
will allow the blood to flow out. But if the openings arent large, blood flow inside the false lumen...
Nicotine rush hinges on sugar in neurons
...rge and important group of molecules, known as ion channel
proteins, that allow signals to pass between neuro...t when a chemical such as nicotine binds to an ion channel
protein on the cell surface, the protein starts a conformational wave that propagates a signal throu...
Scientists a step closer to understanding how anaesthetics work in the brain
...to happen, the stabilising action of the potassium channel
has to be overcome. Earlier studies on great pond ... identified a specific amino acid in the potassium channel
which, when mutated, blocks anaesthetic activation. Lead author, Biophysics Professor Nick Franks fr...
Tumor painting revolutionizes fight against cancer
...few as 200 cancer cells traveling in a mouse lymph channel
could be detected. Chlorotoxin:Cy5.5 is applicable to many cancers, but is especially helpful to surgeons operating on brain tumors. Not only would it reveal whether theyd left behind any bits of tumor, it would also help them avoid removing normal...
Geologists witness unique volcanic mudflow in action in New Zealand
...ar pathway before the breakout to assess pre-event channel
conditions. Although the event was predicted to occur in 2007, the recent decreased filling rate of Crater Lake suggested that the lake bank actually would not be overtopped until 2008. However, several days of intense rainfall and increased seepag...
Sour taste make you pucker? It may be in your genes
...tructures such as the recently-discovered PKD ion channel
are correlated with individual differences in sensitivity to sourness. For any given candidate receptor, a strong association of genetic with perceptual variation would support the likelihood that the receptor detects sour taste. The findings, ...
JCI Table of Contents -- July 2, 2007
...have been mutations in the cardiac calcium release channel
known as the ryanodine receptor (RyR2), which result in calcium leak from the sarcoplasmic reticulum (SR) that can trigger fatal cardiac arrhythmias during stress. In the July 2 issue of the Journal of Clinical Investigation, Jonathan Seidman and col...
Doing nature one better: Expanding the genetic code in living mammalian cells
...agenesis to introduce mutations into the potassium channel
but it didnt give us any answers, says Paul A. Sle...a signal travels along a nerve cell, the potassium channel
Kv1.4, which belongs to a class of so-called fast-inactivating ion channels, opens briefly and then ...
Discovery could help bring down price of DNA sequencing
...tters (PRL). DNA is pulled through the nanopores channel
by an electric force, but there also is a resistiv... of the fluid surrounding the molecule through the channel
with it. The lubrication forces arising in this fluid layer create the resistance that opposes the e...
Bright future for nano-sized light source
...s, and made nanoribbon optical waveguides that can channel
and direct light through circuitry, the new nanowire light source lays firm groundwork for future nanophotonic technology. Photonics, a technology in which the movement of light waves replaces the movement of electrons as information carriers, promis...
News tips from the Journal of Neuroscience
...rozygous mutations in the plasma membrane chloride channel
ClC-2 have been linked to human epilepsy in three ...ficient in Clcn2 . This widely expressed chloride channel
is activated by cell swelling, lowered pH, and voltage. Mice lacking Clcn2 showed spongiform vacuo...
Menthol receptor also important in detecting cold temperatures
New Haven, Conn.The ion channel
activated by menthol also detects a wide range of ...inding solves the mystery of how important the ion channel
TRPM8 is for alerting the body to cold temperatures. TRPM8 is the primary, if not sole, determina...
Cornell lab confirms deadly fish virus spreading to new species
...sport fish), northern pike, walleye, yellow perch, channel
catfish, brown bullhead, white perch, white bass, ...stating impact on aquaculture and particularly the channel
catfish trade, which constitutes about 80 percent of aquaculture business in the United States, said...
Elastic interactions of membrane proteins
...ing their shape to perform specific tasks, such as channel
proteins, which allow the flow of ions in only one formation. Ursell created a physical model which shows that the membrane itself can communicate structural and hence formational information between membrane proteins. Hence, proteins can "talk" and ...
J&JPRD discovery may lead to new treatments for chronic sensitivity, pain caused by cold
...sts used a line of mice that lacked a critical ion channel
receptor called TRPM8, also referred to as the cold menthol receptor 1. Then, they tested how these mice reacted to cold stimuli, and found that not having these receptors reduced their adverse reactions to the cold, both under normal and pathologic...
Scripps research team sheds light on long-sought cold sensation gene
... their paw and lick them. TRPM8 codes for an ion channel
found at the tips of sensory neurons, which innervate the skin. When opened, ions flowing through TRPM8 lead to the activation of the sensory neuron, which in turn sends a signal to the brain. The Patapoutian teams results support the idea that activ...
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