Lab-on-a-chip device from Berkeley Lab to speed proteomics research
... the first report of a silicon/silica microfluidic channel that is integrated monolithically with a multinozzle nanoelectrospray emitter," said Wang. "This paves the way for the large scale integration of mass spectrometry and lab-on-a-chip analysis in proteomics research." Each emitter consists of a paral...National Academy of Sciences elects 2 Brandeis University scientists to membership
...ller studies the molecular mechanisms by which ion channel proteins open and close to switch the flows of ions across cellular membranes, allowing only the ion appropriate to the cellular task at hand to permeate. ...University of Texas researcher earns APS Bowditch award
...s equipped to perform real-time measurement of ion channel activity....Oxford physiology professor earns APS' Walter B. Cannon Award
...ley, discovered another malady associated with ion channel malfunction, a rare genetic form of diabetes that strikes children and is known as permanent neonatal diabetes mellitus. Their discovery produced dramatic changes in the lives of children born with the disease. As a result of their research, these ...Brain networks strengthened by closing ion channels
...c mutation in patients to the regulation by an ion channel of PFC neuronal networks," said Arnsten....What's in the water? Estrogenic activity documented in fish caught in Pittsburgh's rivers
..." said Dr. Volz. The study examined white bass and channel catfish caught in the Allegheny, Monongahela and Ohio Rivers. These fish are among those commonly caught as a food source by local anglers. The experiments to determine if estrogenic substances were present in the fish were performed in the labora...JCI table of contents: April 12, 2007
...lmodulin regulation of cardiac muscle Ca2+ release channel AUTHOR CONTACT: Gerhard Meissner University of North Carolina, Chapel Hill, North Carolina, USA. Phone: (919) 966-5021; Fax: (919) 966-2852; E-mail: meissner@med.unc.edu . View the PDF of this article at: https://www.the-jci.org/article.php?id=2...News tips from the Journal of Neuroscience
... transcription-PCR that the bulk of L-type calcium channel transcripts in granule cells encoded Ca v 1.2 subu...ss a metabolic sensor, the ATP-sensitive potassium channel K ATP . In rodent brain slices, ketone bodies (β- hydroxybutyrate or acetoacetate) slowed the f...... distress signals converge on a single pathway and channel the information to a nuclear master switch, the scientists report in the March 29 issue of Science Express. In response, hundreds of genes involved in photosynthesis are simultaneously shut off to ease the chloroplast crisis. Plants store the bulk ...Healthy coastal wetlands would adapt to rising oceans
...n sea level, the model builds a marsh platform and channel network (that rises) with the rate of sea-level rise, meaning water depths and biological productivity remain temporarily constant," said the new report. "If the vegetation is intact, it holds the system in place and enhances the trapping of sedime...Protein overexpression at heart of heart failure
...eta 2-subunit) that is responsible for the altered channel behavior in human heart failure. Similar changes o...sion transgenic mouse which was crossbred with the channel pore overexpressing mouse when still nonfailing (Adaptive phase). In the nonfailing double transgeni...First new waterborne aquaculture drug in 20 years approved
...h these diseases include trout, salmon, steelhead, channel catfish, and tilapia. Rosalie Schnick, National Coordinator for Aquaculture New Animal Drug Applications, said, The scientists at the Upper Midwest Environmental Sciences Center did an excellent job completing the major data requirements for obtaini...News tips from the Journal of Neuroscience
...le diameter. In mice lacking Kir4.1, the potassium channel that is expressed at glial endfeet adjacent to arterioles, light-evoked vasodilation was similar to wild-type mice. If its not potassium siphoning, what is it? The authors suggest that glial-derived arachidonic acid metabolites, known to contribute t...UC Davis researchers discover key to body's ability to detect subtle temperature changes
...colleagues now have shown that the subunits of one channel can come together with subunits from another channel or coassemble in laboratory cell cultures to form new functioning channels. Assuming this process al...Fruit flies may pave way to new treatments for age-related heart disease
... The study reports that mutations in a molecular channel found in heart muscle cell membranes caused arrhyt...function." The researchers focused on a membrane channel in the tiny Drosophila heart called KCNQ. This membrane channel, found in flies and humans, regulate......itch on for only very brief periods; and scheduled channel polling which synchronizes and schedules the liste...-MAC utilizes 'low-power listening,' which detects channel activity very quickly. "It further reduces the transmission cost by synchronizing the listening sc...The connector rotation hypothesis? Phage do not pack their DNA by rotation
...hat the DNA passes into the capsid shell through a channel formed by a structure called the connector. Scientists have speculated that rotation of the connector complex might feed the DNA into the capsid as it turns. In a new study published online this week in the open access journal PLoS Biology, researc...Neuroscientists explain inner workings of critical pain pathway
... colleagues discovered a unique form of the N-type channel in nociceptors, neurons that carry pain signals to the spinal cord. These are the channels that opioids act on. But what makes the channels in nociceptors so special? In their new work, Lipscombe and her team uncover the answer. All N-type channel...UTSA researchers examine effects of global warming on Antarctic
...through the ice and create a 25-mile long shipping channel that would allow for the delivery of annual supplies to NSF's McMurdo Research Station. On route to Antarctica, the ship passed through 1,700 miles of extensive sea ice cover that surrounds the continent annually. "We now know what the sea ice re......ny system of channels separated from each other by channel walls made of the water-repellent polymer. As a p...tesides and his team selected a clover-leaf-shaped channel system: A main channel branches into three tiny chambers. Different color reagents are introduced in...