Chemical that triggers hibernation may protect muscles
...an opiate receptor antagonist), HWP plus potassium channel blocker, and various control groups. After 30 minu... protective effects. They administered a potassium channel blocker with the HWP, using dimethylsulfoxide (DMSO) as a solvent. However, since DMSO is itself ass...New research provides evidence that Rh proteins act as CO2 gas channels
...ional evidence that the Rh protein serves as a gas channel for carbon dioxide (CO2). The study's conclusions,...ole is secondary to its original function as a gas channel for CO2," said Kustu. "It seems to be a newly evolving role that increases gas transport in red cell......isease. Pessah's research group works with calcium channel modulators and other biomolecules derived from plants and scorpion venom. But when Pessah and Molinski got to talking at a party some years ago, they quickly realized that they could apply the same methods to screen 124 sponges that Molinski's group ...Vampires beware: Scripps scientists describe molecular basis of raw garlic's pungency
... the allicin in raw garlic activates a pair of ion channel proteins called TRPV1 and TRPA1 that are expressed on pain-sensing neurons in the mouth. Garlic Has Caused Bad Breath for Thousands of Years Garlic ranks second only to salt, perhaps, in terms of flavoring humans have added to food through...Phase III clinical program evaluates lubiprostone
...egardless of gender. Lubiprostone is a chloride channel activator, a novel compound with a unique mechanis... in the GI tract by activating a specific chloride channel (CLC2). Chloride channels are proteins that carry chloride on cells lining the small intestine. Whe...JCI table of contents June 1, 2005
...nhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia AUTHOR CONTACT: Rene Bindels Radboud University Medical Center, Nijmegen The Netherlands Phone: +31-24-3614211; Fax: +31-24-3616413; E-mail: r.bindels@ncmls.ru.nl View the PDF of...Gene implicated in chronic kidney disease
...ead author of the study. Drugs that target the ion channel might offer an effective treatment to slow or prev...ow of calcium. "This gene represents the first ion channel to be associated with FSGS," Winn said. "It's a new mechanism for kidney disease, which may allow us...Newly discovered genetic disease sheds light on body's water balance
...nts inside the cell. Vesicles containing the water channel Aquaporin 2 (AQP-2) are shuttled from the cytoplasm to the apical membrane of the collecting duct kidney cells. This process increases water permeability and diminishes urine output from the kidneys. The group set out to prove that changing the amino...Environmental technologies earn award for PNNL
...n from activities associated with jetty repair and channel deepening, and aid restoration of critical estuarine habitat. PNNL and the National Oceanic and Atmospheric Administration have successfully tested the system for the U.S. Army Corps of Engineers on fish released at Bonneville Dam and monitored at th...River restoration field booms, matures
...anks to curb erosion, recreating the natural river channel to reduce downstream flooding, and removing dams to allow fish to migrate freely up and downstream. According to the authors of the paper, at least $14 15 billion has been invested in river restoration since 1990 an average of $1 billion per year. ...Scientists take major step to improve river restoration efforts
...anks to curb erosion, recreating the natural river channel to reduce downstream flooding, restoring wetlands to filter pollution, and removing dams to allow fish to migrate freely up and downstream. Restoring the natural form and function of rivers and streams helps reverse a decline in water quality. Pennsy...The state of river restoration in the US
..., water quality management, bank stabilization and channel reconfiguration. Project goals are similar in other Southeastern states, although land acquisition for stream restoration is less frequently done in Georgia than in other Southeastern states included in the database. Median cost of restoration proj...Wisconsin researchers identify sleep gene
...a (fruit fly) gene, called Shaker, produces an ion channel that controls the flow of potassium into cells, a ...utation. Because of the mutation, a functional ion channel could not be formed on the cell membrane and potassium therefore could not flow through it. When th...Scientists propose new method for studying ion channel kinetics
...y have developed a new method for the study of ion channel gating kinetics. An ion channel is a protein pore that lets ions (charged atoms such as calcium) pass through a cell's membrane. The...Putting ecology back into river restoration
...criteria is to do no lasting harm. "For example, a channel modification project should minimise loss of native vegetation during river reconstruction, and should avoid the fish spawning season for construction work," Palmer explains. The final criteria is ecological assessment. According to Palmer: "It is cr...Fat may affect electrical impulses in brain, heart
...a meter that measures charge in a battery, a Kv1.1 channel senses the amount of voltage between the interior ... the membrane packing, changes the movement of the channel protein and alters the voltage needed for it to open or close." The researchers identified the spec...Why do amyloid diseases strike different tissues?
...Kelly. For example, in cystic fibrosis, a chloride channel (CFTR) that is required on the surface of lung cells to make them function properly, is trapped instead in a partially folded state in the endoplasmic reticulum and degraded. By understanding the new rules that couple protein folding kinetics and the...Remote control flies?: Fly behavior controlled by laser light
...membrane. The small molecule ATP activates the ion channel chosen by the researchers, so ATP became the key. To keep the ATP from binding to the ion channel and jump-starting the nerve cell's activity before the proper moment, Lima and Miesenbck caged the A...Protein tags regulate key ion channel
...a new chapter to the book of how cells control ion channel function: reversible peptide linkage." Ion channel...nnel." Goldstein's team discovered the type of ion channel known as background (or leak) potassium channels in yeast cells in 1995 and in fruit flies in 1996. ......'t perform their basic, everyday functions. Sodium channel genes in different vertebrates are virtually ident...might think that this sort of change in the sodium channel would be too costly to the snakes," said Utah State University biologist Shana Geffeney, who conduct...