Tag: "clathrin" at biology news
News tips from the Journal of Neuroscience
...ls stably expressing YPF-HA-DAT. Not surprisingly, clathrin
heavy chain and dynamin emerged from the screen as molecules critical for endocytosis. Knockdown of the ubiquitin ligase Nedd4-2 (neural precursor cell expressed, developmentally downregulated 4-2) also reduced endocytosis, consistent with the idea t...
Novel nuclear function of clathrin
... colleagues report on a novel nuclear role for the clathrin
heavy chain protein as a p53-dependent transcriptional cofactor. The researchers found that clathrin
heavy chain (CHC), which was heretofore solely recognized as a cytosolic component of the intracellu...
New insights into the mechanism for internalization of ubiquitinated cargo
...ifs) of endocytic adaptors, which are localized to clathrin
coated pits, function to mediate the internalization of ubiquitinated cargo. These two studies argue against monoubiquitinated cargo being internalized via caveolae. An accompanying commentary discusses how these results relate to the existing liter...
When it comes to cell entry, being average has its advantages
...n that flu viruses can invade cells even without a clathrin
coat. Along with Huajian Gao and Wendong Shi from Max Planck, Freund created a mathematical model that can account for this. Particle size plays a key role. According to the team's new model, cells take in viruses and other particles with a diameter ...
Researchers develop assay that could be applied to drug screening
...most important routes for cargo internalization is clathrin
mediated endocytosis (CME). CME is of fundamental ...aid. "For instance, it wasn't known whether single clathrin
coated pits give rise to single clathrin
coated vesicles. We have now shown directly that coated pit...