Penn receives grant for initiative to help understand genes' effects on medications
...f each other," explains Kimmel. "But it has become clear that progress in medicine is a dynamic, multi-faceted process. The conventional divisions within biomedical research may hamper the pace of scientific discovery and ultimately, deliverable benefits to patients. This problem is particularly relevant i...32 new grants made for innovative technology R&D
...efits, the need for ATP funding, and evidence of a clear commercialization pathway and broad diffusion. As a non-regulatory agency of the U.S. Department of Commerce's Technology Administration, NIST develops and promotes measurement, standards and technology to enhance productivity, facilitate trade and i...Fungus knocks a frog down but not out, raising questions about amphibian declines
...frogs coexist with the fungus during that time, or clear it and then live as normal healthy frogs. Understanding that would give us some insight into how the fungus operates in the wild." The researchers found a steady rate of infection from year to year, but a higher rate of infection in samples ...Stanford cooling tool may improve performance of athletes, soldiers
...s. "Our technology would certainly give athletes a clear competitive edge," Grahn notes. "We've seen that the rapid increases in strength people get when using the device persist after they stop using it. So, whatever physiological benefit you get, you keep. That's the beauty of it." ...Putting physiology into the Nobel Prize: 2004 marks 100th anniversary of Pavlov's award
... "physiological function. From this time on it was clear that if integrative physiology was to be comprehensive, it had to deal with aspects of central neural integration that in this century have been claimed by psychology," Smith wrote. "That problem is still with us and is likely to remain for some time...'Immediately open access' option for the leading journal Genome Research
..., Managing Editor of Genome Research added, "It is clear that some scientists, many of them active in the genome science community, are personally committed to the philosophy of open access and have the resources to support the 'author-pays' model of publication charges. By making the immediately open acce...Brain circuit may permit scientists to eavesdrop on memory formation
...he lifetime of the memory. In addition, there is a clear need for the hippocampus and cortex to talk to one another." One candidate for the communication conduit is the temporoammonic (TA) projection, "a pathway that we have been chipping away at understanding for years," said Schuman. "We and others had s...The PSA bounce Does it have clinical significance?
...ary. For these reasons, it's important to develop clear guidelines." In this retrospective analysis, data were gathered from the records of 4,839 men treated only with external-beam radiation between 1986 and 1995 at nine institutions throughout the US. The median follow-up was 6.3 years. Treatment dur...UF scientists have bionanotechnology recipe to find elusive bacteria
...critical issue, I think our technology will have a clear edge."...Experimental drug prevents vaginal simian HIV transmission in monkeys Science study says
...uing its multi-step infection process. It is not clear what PSC-RANTES concentration would be needed to block HIV infections in humans -- if research were to progress that far. The concentration that prevented infection in all five monkeys is far greater than the concentrations sufficient to block infect...Perceptual decision-making hub pinpointed in human brain
...nding on a street corner in a downpour versus on a clear day. Hard to discern images evoke a relatively slower and reduced response in the decision-making area, as it mulls the strength of competing signals from specialized visual processing areas, where neurons fire only to the extent that they see certa...Multi-species herbivore outbreak follows El Nio drought in Panama
...98. Van Bael cautions: "It's becoming increasingly clear that we should pay attention to these harbingers of climate change. A better understanding of the deep natural history of these systems may help us to predict outbreaks involving crop pests or human disease vectors."...Manipulation of epigenome turns off as many genes as it turns on
...what effect all these changes might have, but it's clear that when scientists are looking only at the agents' effects on a particular gene or a few particular genes, they aren't seeing the whole picture," says Andrew Feinberg, M.D., M.P.H., King Fahd Professor of Medicine at Johns Hopkins. Their report app...Hormone therapy's effect on breast density is not the same for all women, Group Health study finds
...ct breast cancer on mammograms. But it hasn't been clear whether this increase happens for all women, or whether it differs based on various breast-cancer risk factors, the type of HT a woman uses, and the length of time she takes it. A new study, conducted by Erin Aiello, MPH, and colleagues at Group Heal...High fiber intake reduces estrogen levels in Latina women, according to researchers
...dence of breast cancer. "This study provides clear evidence of an association between dietary fiber intake and circulating hormone levels in postmenopausal Latina women," the researchers note, "and potentially provides a dietary means for lowering a woman's risk of breast cancer." ......l. By 7 weeks old (adulthood for mice), there were clear structural changes in the knee joints, and the articular cartilage was thinner and showed signs of wearing away. By 9 months old, the knees of the mutant mice largely lacked articular cartilage. All told, the joints in these mutant mice closely resem...Gene linked to greater risk of heart disease in type 2 diabetes
... factors are involved," said Dr. Doria. "But it is clear that in addition to high blood pressure, high cholesterol and environmental factors such as smoking, genes are important determinants of heart disease in people with type 2 diabetes." An International Research Team In addition to Dr. Doria, other J...Other highlights in the October 20 JNCI
...ot weigh more than their siblings. There was not a clear association between birth weight and risk of childhood AML. Contact: Lisa Lyngsie Hjalgrim, Statens Serum Institut, 45-32-68-39-51, lih@ssi.dk Study Suggests an Effective Treatment for Overdose of Intrathecal Methotrexate An injection of methotre...Mitochondrial mutation linked to blood pressure and cholesterol problems
... also linked to mitochondrial disfunction. The clear correlation of mutation and disorder in this study...on a rare mutation in mitochondria that provides a clear link to specific disorders, mitochondrial function is known to decline with age in normal people and...Single genetic defect links many risk factors for heart disease and stroke
...nheritance is complicated, and there hasn't been a clear understanding of what's driving this relationship." Various combinations of these abnormalities affect up to a quarter of the U. S. population, and they are contributing to a public health epidemic of heart disease and stroke. Lifton said that one ...