Tag: "cleaved" at biology news

JCI table of contents, November 15 2004

...sses. Produced in a precursor form, pro-SF must be cleaved in order to activate its receptor, Met tyrosine ki... tail of the cell surface receptor polycystin-1 is cleaved and released from the cell membrane by a process known as regulated intramembrane proteolysis where ...

Inactive form of scatter factor protein found to suppress tumor growth and spread

...sses. Produced in a precursor form, pro-SF must be cleaved in order to activate its receptor, Met tyrosine kinase. In the November 15 issue of the Journal of Clinical Investigation, Paolo Michieli and colleagues developed an uncleavable form of pro-SF and used it in a gene therapy approach in mice to inhibit...

Healthy cleavage: How statins protect against Alzheimer disease

...id-beta (A b ) peptide, a protein fragment that is cleaved off from the amyloid precursor protein APP. APP can be cleaved in two different ways. Amyloidogenic ("amyloid generating") cleavage by an enzyme called beta-secret...

Pro-inflammatory protein contributes to Crohn's disease according to UCSD School of Medicine study

...rsors, whose synthesis is stimulated by NF-kB, are cleaved and the mature protein can be secreted. Therefore finding high levels of IL-1 secretion in the mutant mice suggested that in addition to activating the NF-kB, that mutant NOD2 also stimulated the processing of the IL-1 precursor into its mature form....

Neuronal 'traffic jam' marks early Alzheimer's disease

...onal transport. A defective version of beta-APP is cleaved to form an aberrant form of amyloid beta (A-beta) peptide that makes up the plaques that surround the neurons of people with Alzheimer's disease. "With the findings from fruit flies as our guide, we decided to look at mouse models of Alzheimer's dise...

Nobel laureates to open ASBMB annual meeting in San Diego

...s the process by which membrane-bound proteins are cleaved and fragments are released into the cell's cytosol...ption factor that projects into the cytosol and is cleaved by RIP. By modulating the processing of SREBPs, RIP directly controls membrane lipid composition and...

Side effects

... the enzyme structure. While the prodrug is indeed cleaved by an active site near the bottom of the drug-converting enzymes' gorge, in AChE it is trapped in such a way that the active site can't cleave it. Instead, the prodrug blocks the enzyme like a cork, rendering it useless. "The enzymes are like locks ...

Combating antibiotic resistance

...response to the damaged DNA, the LexA repressor is cleaved and no longer inhibits transcription of the SOS response genes. Romesberg's group proposes that antibiotic-mediated DNA damage generates a reduction in the concentration of LexA that is sufficient to increase the expression of three nonessential DNA ...

Finding an Alzheimer's switch

...r protein 2), and Psn-1 (presinilin 1) -- which is cleaved into two parts in the mature complex, Psn-1 NTF (t...e molecular mechanisms by which the substrates are cleaved in various forms -- and the next crucial step to designing Alzheimer's disease therapeutics." "CD14...

MMP inhibitors may offer hope in the fight against prostate cancer-induced bone disease

...bone destruction. The researchers found that MMP-7 cleaved a molecule called RANKL into a soluble form that promoted osteoclast activation and bone degradation. Mice deficient in MMP-7 had little to no soluble RANKL and exhibited substantially reduced prostate cancer-induced bone degradation compared to cont...

Brain size may depend upon how neural cells are cleaved

...tion in which dividing neural progenitor cells are cleaved during development. The way these cells are sliced during development is critical because at later stages of neurogenesis, vertical cleavage gives rise to two mature neurons that are incapable of further division, while horizontal cleavage yields one...

Penn researchers discover key to how SARS virus infects cells

...irst examples of the need for these proteins to be cleaved during infection of the host cell. This work is a joint collaboration between the Bates lab and the research group led by Scott L. Diamond, PhD, Director of the Penn Center for Molecular Discovery, one of nine facilities that the National Institutes ...

'Smart' nanoprobes light up disease

...ystem, the Rice team used a peptide tether that is cleaved by the enzyme collagenase. The researchers first showed that luminescence of the quantum dots was cut by more than 70 percent when they were attached to the gold particles. They remained dark until the nanostructures were exposed to collagenase after...

Competing proteins influence strength of tooth enamel

...o tooth formation expresses a protein that is then cleaved into two proteins with seemingly opposite functions, according to a USC-led team of dental researchers. The team's study of the two proteins, dentin sialoprotein (DSP) and dentin phosphoprotein (DPP), has been accepted by the Journal of Biological C...

New gene regulation mechanism discovered

...cal mCAT2 messenger RNA in the nucleus was rapidly cleaved in response to interferon treatment, and that the protein coding portion of the molecule was then quickly exported to the cytoplasm and translated into protein (ILLUSTRATION AVAILABLE ON REQUEST). "This 'cut and run' mechanism is a completely new par...

Molecule does more than slice and dice RNA

...nvolved in downstream events, how it hands off the cleaved RNA and directs it to the right gene targets. Resolving the structure of Dicer, Doudna noted, was a technical challenge as the crystals are small. But she said that the work was facilitated by access to the HHMI-supported crystallography beam lines a...

Missing steps of jumping-gene replication discovered

...hen the retrotransposon inserts by binding to that cleaved DNA strand and copying itself onto that strand," she says. "It sneaks in there." How the retrotransposon finally integrated and pasted itself back together was unknown, until this paper. "What we saw in our insertions hinted at the possibility that ...

JCI table of contents: March 1, 2006

... lamin A or prelamin A, the latter of which can be cleaved to form mature lamin A, are healthy. The authors created these "lamin Conly mice" using two different model systems. The first method involved mutating the Lmna mouse gene. In addition, the researchers treated normal mice with short DNA molecules to ...

Computer simulation hints at new HIV drug target

...vity. That is where enzymes and other proteins are cleaved into the parts necessary to assemble infectious virus particles. Structural studies of this cavity helped scientists find the original protease inhibitors. Other scientists are trying to design drugs to bind to the whiskers and or to lock down the fl...

Prediction of a prokaryotic RNA-silencing system

...ences via the formation of a duplex, which is then cleaved by Cas proteins to destroy the foreign RNA....

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