Other highlights in JNCI, June 12
...Extensive and complete chronic toxicity testing in clinical trials is warranted before the further development of deguelin as an anticancer therapeutic agent, the authors write. Contact: Laura Sussman, press office, M. D. Anderson Cancer Center, 713-745-2457, lsussman@mdanderson.org Also in the June ...BRCA2 carriers at increased risk for deadly form of prostate cancer
... diagnosed with cancer. Nonetheless, the immediate clinical utility of these findings is limited, despite unusually rigorous design and analysis, the authors write....Breakthrough developments in rheumatoid arthritis reported
...rch subjects with rheumatoid arthritis. With these clinical features at his side, he turns to the basic building blocks of life the human genome to figure out what makes these people susceptible to the disabling inflammatory condition. Dr. Gregersen has finally closed the circle between key genes identi...'Lucky 13' as new gene discovery offers further hope for childhood blindness
... Hospital, London, recently announced the start of clinical trials for a gene therapy involving injecting gene...our findings, together with the recently announced clinical trials, hold great promise." Mutations in LCA5 are relatively rare. As it is a recessive gene, a c...Genetic defect links respiratory disease and congenital heart disease
... ciliary dysfunction," said Dr. Blair V. Robinson, clinical associate professor of pediatrics at UNC-Chapel Hill and an author of the study. "In addition, the associations between ciliary function, the heart defects and the organization of organs in the chest and abdomen will hopefully lead to better understa...Methodist, University of Houston, Cornell combine biomedical imaging expertise
...n this growing field of biomedical science and its clinical applications. The three institutions have jointly founded the Institute for Biomedical Imaging Science (IBIS). This Institute will create interdisciplinary programs in the sciences of biomedical imaging and will foster joint training programs to...Researchers shed light on mechanism of action used by anti-cancer drug
...eral such targeted agents are currently undergoing clinical evaluation in patients with various malignancies....ChemGenex announces publication confirming activity of Ceflatonin in T315I-Positive CML
...ature publication Leukemia confirming the positive clinical activity of the company's lead compound, Ceflatoni...hieved after three cycles of therapy. Based on the clinical results, the authors believe that the rapid and complete disappearance of the T315I mutation might s...University of Liverpool launches 10 million small animal teaching hospital
...ities will enable Liverpool to provide world-class clinical treatment for cats and dogs as well as support a programme of research projects into diseases affecting small animals. Our veterinary students will be trained in the most-up-to-date techniques available, which mean our graduates will consequently ...Boosting key milk nutrients may protect against cancer
...Journal of Clinical Nutrition. (1) The four-year clinical trial included more than one thousand women over t...encouraged by these findings. This is the first clinical trial to show that boosting vitamin D status can affect the overall risk for cancer a proposition t...Hormone that signals fullness also curbs fast food consumption and tendency to binge eat
...the studys senior author and executive director of clinical research at Amylin Pharmaceuticals, Inc., in San Diego, Calif. The findings of our clinical study further suggest that satiety hormones such as amylin can exert multiple effects on human eatin...Studies to find better ways to preserve human eggs, ovarian tissue under way
...ysterectomy for benign disease, says Dr. Song, MCG clinical associate professor at MCG and director of research for Augusta-based Xytex Research/Xytex International. Collaborators at the University of Texas Health Science Center and M.D. Anderson Cancer Center are doing the same. With some of the tissue, th...SNM advances professional definition for 'molecular imaging'
...concrete information on an emerging scientific and clinical specialty, said David A. Mankoff, chair of SNMs MICOE Standard Definitions Task Force. Input from task force memberswith a broad range of backgrounds and expertise, including individuals outside of nuclear medicinewas key in generating the molecular ...Talcum powder stunts growth of lung tumors
...ng properties would lead to a cure for cancer. But clinical trials have been disappointing, possibly because m...ients life, Antony said. Yossef Aelony, M.D., a clinical professor of respiratory and critical care medicine at the Harbor-University of California at Los An...Largest ever study of genetics of common diseases published today
...h and in inflammatory bowel disease and could have clinical significance in the future. "The link between type 1 diabetes and Crohn's disease is one of the most exciting findings to come out of the Consortium," says Professor John Todd from the University of Cambridge, who led the study into type 1 diabetes...University of Pittsburgh scientists find new contributor to aggressive cancers
... level of integrin 7 expression is associated with clinical relapse of human cancers. They also investigated whether integrin 7 has tumor suppressor activity. To determine whether mutations in integrin 7 contribute to cancer, Dr. Luo and his collaborators sequenced the integrin 7 genes from 66 human cancer...Research team identifies new Alzheimer's gene
...ture of how life works and ultimately allow better clinical management of patients, said Dr. Dietrich Stephan,... will enable Kronos to develop a test that aids in clinical diagnosis and help determine a persons genetic predisposition for developing Alzheimers disease. T...New algorithms classify outcomes of nonsmall cell lung cancer patients
...ch teams have developed models for classifying the clinical outcomes of patients with nonsmall-cell lung cance...ups, who were not treated with the drug. In the clinical development of biomarkers for the individualization of therapy, it is important to distinguish betwe...Cisplatin is more effective than carboplatin for treating nonsmall cell lung cancer
...rboplatin does not justify its preferential use in clinical practice. However, all the progress in the treatment of advanced NSCLC has been made in small increments, the authors write. In an accompanying editorial, Christopher Azzoli, M.D., and colleagues at the Memorial Sloan-Kettering Cancer Center in Ne...Older men may not live as long if they have low testosterone
...searchers agree only randomized placebo-controlled clinical trials can determine whether testosterone suppleme...nnor and a team of UCSD researchers have conducted clinical research visits with the participants every four years for more than three decades. The clinical...