Tag: "clotting" at biology news

Cigarette smoke a culprit in poor healing and increased scarring

...d tissue remodeling. It features an exotic cast of clotting and growth factors, specialized cells and structural proteins, each of which must time their entrance and exit perfectly. Nothing messes up this timing like cigarette smoke. Clinical studies have consistently shown that individuals exposed to cigaret...

A new New Year's reason to work out: Exercise improves three measures of heart protection

...omen who are more physically fit have better blood clotting profiles than women who are unfit. These positive ...so they tested blood-clotting variables, including clotting and fibrinolysis the ability to prevent or break up blood clots. The study, "Relationship of physic...

Despite causes of lupus proving complex, critical 'checkpoint' suggesting new therapy is revealed

...y failure, seizures and neurological damage, blood clotting and respiratory inflammation -- associated with the disease. The findings are reported in two new publications, one in the January 28 edition of Science and another in January's Nature Immunology. "Our Science publication makes an important new poin...

Embryonic stem cells treated with growth factor reverse hemophilia in mice

... (Feb. 15). The genetically altered mice lack the clotting substance factor IX, which in humans results in the hereditary bleeding disorder known as hemophilia B. This disease, much less common than hemophilia A, affects roughly one of every 35,000 people, primarily males. Although embryonic stem, or ES, ce...

Polymers with copper show promise for implanted sensors

... to mimic what occurs in the human body to prevent clotting on the walls of your own blood vessels," said Meyerhoff. "Your endothelial cells---the cells that line all of your blood vessels---generate nitric oxide. The nitric oxide produced in this layer of cells diffuses back into the blood vessel walls, wher...

JCI table of contents April 1, 2005

...rin to explore how such therapy would impact blood clotting and reproductive functions. The mice generated have reduced levels of prostaglandin H synthase 1 (PGHS1), a platelet protein that contributes to the heart-healthy effects of aspirin therapy. The authors find that these mice had the expected decrease...

Birthing a new model of aspirin therapy in preeclampsia

...rin to explore how such therapy would impact blood clotting and reproductive functions. The mice generated have reduced levels of prostaglandin H synthase 1 (PGHS1), a platelet protein that contributes to the heart-healthy effects of aspirin therapy. The authors find that these mice had the expected decrease...

U of M researcher examines newly emerging deadly disease

... it is typically characterized by the depletion of clotting factors in the blood and skin lesions. Purpura fulminans refers to widespread severe purpura with extensive tissue damage and sloughing of skin. Purpura are skin lesions that may be many centimeters in diameter caused by the leakage of blood into t...

Pregnancy complications related to low levels of anticlotting proteins

...y in pregnancy may act together with other genetic clotting tendencies to adversely affect pregnancy, accordin...eins can help determine which women with inherited clotting problems are at risk for pregnancy complications and how they should be treated. The study included ...

Gene therapy completely corrects hemophilia in laboratory animals

...troduced into the animals' cells a gene that makes clotting factor VIII, a protein missing because of a geneti...ch in many other cases eventually blocks the blood clotting activity of introduced factor VIII in hemophilic animals. Since treatment more than a year ago, the ...

Gene variants predict bleeding after heart surgery

...resence of specific variants of genes that control clotting and the contractility, or "tone," of blood vessels...ory system, three main factors control bleeding or clotting blood vessel constriction, platelet activation and the activity of clotting factors that circulate ...

Seeing what protein C is all about

Protein C (ProC) is a protein involved in blood clotting and inflammation. Patients with defective ProC activity suffer from thrombotic complications, which can result in stroke and/or hypertension. There was thus a need to develop an animal model for severe ProC deficiency. This has been difficult since...

Researchers find genetic link to cerebral hemorrhage and porencephaly

...uence of fetal trauma and/or genes affecting blood clotting that predispose to hemorrhage. An international team discovered a genetic defect that weakens blood vessels in the brain, making an infant much more vulnerable to hemorrhaging. The team was led by Dr. Douglas Gould a postdoctoral fellow at The Jackso...

Genetic variation alters response to common anti-clotting drug

...the anticoagulant drug warfarin to prevent harmful clotting after a heart attack, stroke, or major surgery. Bu...earned that variations in a gene involved in blood clotting may explain why certain people require a lower or higher dose of warfarin to get its full benefits. ...

'Laser tweezers' reveal microscopic mechanical properties of blood clots

...ical properties are essential for its functions in clotting and also are largely responsible for the pathology of thrombosis that causes most heart attacks and strokes." By understanding the microscopic mechanical properties of a clot and how that relates to its observed function within the circulatory system...

Redesigned protein accelerates blood clotting

...e reactions," Fay said. Study Details Blood clotting involves more than a dozen clotting factors, many named with roman numerals. They form a cascade of chemical reactions inside blood ves...

Key process in gene regulation occurs in blood platelets, Univeristy of Utah researchers find

...ly the heart; when blood has too few platelets and clotting is impaired, hemorrhaging can occur. Blood platelets are formed in bone marrow when a parent cell, a megakaryocyte, sends out arm-like extensions called proplatelets. Platelets bud off from these extensions, separating from the cell body and nucleus,...

NIH renews network focused on how genes influence drug responses

...y to medicines, including aspirin, used to prevent clotting and treat cardiovascular disease. (Alan R. Shuldiner, M.D., University of Maryland School of Medicine) Pharmacogenetics of Phase II Drug Metabolizing Enzymes --$12.6 million provided by NIGMS and NCI to characterize variations in genes encoding...

Improved blood safety measures from Pall can increase platelet availability

...lets are the blood component responsible for blood clotting functions, and are typically diminished in patients undergoing chemotherapy, treatments related to organ transplant or victims of severe burns. They are essential blood products in times of emergency such as radiation exposure during an environmenta...

Carbon nanoparticles stimulate blood clotting, researchers report

...y experiment on human platelets blood's principal clotting element and in a model of carotid artery thrombosis, or blockage, using anesthetized rats. "We found that some carbon nanoparticles activate human platelets and stimulate them to aggregate, or clump together. We also demonstrate that the same nano...

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(Date:10/17/2014)... news release is available in German . ... only a very few drugs. When treating overdoses, doctors are ... is especially difficult if there is a combination of drugs ... playing and accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe ... wanted to find an answer to this question. "The task ...
(Date:10/16/2014)... William and Mary,s Virginia Institute of Marine Science ... Environmental Protection Agency to identify the streams and ... develop tools to help local governments and citizens ... critically on a dataset of tidal-marsh observations first ... with this historical baseline can today,s researchers accurately ...
(Date:10/16/2014)... Melbourne researchers have challenged conventional thinking on how the ... new mechanism for how bowel cancer starts. , The ... maintaining and regenerating the ,crypts, that are a feature ... are involved in bowel cancer development, a controversial finding ... existence. , Using 3D imaging technologies, Dr Chin Wee ...
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