NHGRI seeks next generation of sequencing technologies
...produce conical nanopores in a synthetic membrane, coat the pores with gold, modify the pores to control DNA transport and then introduce chemically modified DNA. The goal will be to detect different signals from each of the four types of nucleotides as DNA passes through the pores. Andre Marziali, Ph.D.,...Mystery unwrapped: Texas A&M team uncovers mummy secrets
... Coast, where native Indians used the substance to coat canoes and boats. But that occurred about 2,000 years after the Egyptians learned the trick. "Another interesting thing we learned was that some of this tar used by the Egyptians didn't come from nearby areas, but from hundreds of miles aw...Visualizing the end of the human genome
...n't a multiple of six." Cech said. "If you need to coat something that has a repeating motif of six, you need to bind some multiple of six." To understand how human POT1 recognized and bound to the telomere, the researchers crystallized a form of POT1 bound to the critical ten-nucleotide segment of ...Common lineage suggested for viruses that infect hosts from all three domains of life
...es studied, one vertex of the apparently symmetric coat is different and used for DNA packaging. With this...s could explore whether human viruses with similar coat proteins also have a unique vertex devoted for DNA packaging. If so, new anti-virals could be devel......phological traits such as body size, skull traits, coat color, and striping patterns--may be flawed. To get a clearer picture of the genetic structure of existing tiger populations, Shu-Jin Luo, Jae-Heup Kim, Stephen O'Brien, and colleagues have performed a comprehensive genetic analysis of over 130 tige...UCLA scientists transform HIV into cancer-seeking missile
...A. Second, the scientists stripped off HIV's viral coat and redressed it in the outer suit of the Sindbis virus, which normally infects insects and birds. By altering the Sindbis coat, they reprogrammed the AIDS virus, which ordinarily infects T-cells, to hunt down and attach to P-glycoproteins -- molecu...Tiny particles could solve billion-dollar problem
...onsists of a gold nanoparticle covered with a thin coat of palladium atoms. As metal particles get progressively smaller, a higher percentage of the atoms in the particle are found on the surface of the particle instead of being locked away inside the metal where they cannot interact with other chemicals....To control germs, scientists deploy tiny agents provocateurs
... harmful and beneficial. In one role, biofilms can coat plant roots and symbiotically aid ecological processes such as nitrogen fixation. But at the darker end of the scale, biofilms can form infection-inducing layers on implanted medical devices and cause deadly lung infections in cystic fibrosis patient...Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
...cells might also contribute to fatty buildups that coat arteries and lead to heart disease, UT Southwestern Medical Center researchers have found. The molecule, called apoptosis inhibitor of macrophage or AIM, inhibits cell death in macrophages, which circulate in the bloodstream and help the body fend of...Why do amyloid diseases strike different tissues?
...-line in some generic factory. A person in a white coat examines each package as it goes down the line, compares it to a standard, and if any package is damaged, then discards the damaged product. Quality control in protein secretion was thought to function similarly: any protein not comparing favorably t...Method shows how precisely gene expression signals are copied in DNA replication
...s. "In a calico cat, different genes that express coat color are on and off in different parts of the cat's coat, so you get patches of different-colored fur," Genereux said. Methylation typically passes from genes in a DNA strand to the same genes in a daughter strand created during DNA replication. Th...Can our genes tell the story of our divergence?
...illion to 6 million years ago, we shed our hirsute coat and heavy brow, mastered bipedal locomotion, and acquired a knack for abstract thought while our next of kin learned to use tools, and developed the skills to construct tree-bound nests high above the forest floor. We differ by just a tad over 1% at ......egnancy. There is no immediate survival value when coat thickness is determined, but later on it matters a lot to the offspring. Many human traits are likely to operate in a similar manner. Some programming traits are even passed onto subsequent generations possibly by affecting genes, eggs within a de...Photos reveal new primate species
...peratures frequently drop below freezing; its long coat is probably an adaptation to the cold. The taxonomic name of the species, Lophocebus kipunji, recognizes the monkey's local Kinyakyusa name (pronounced kip-oon-jee) used by a few hunters around Mt. Rungwe. The highland mangabey is extremely rare and ...Quantum dots provide a faster, more sensitive method for detecting respiratory viral infections
...olecular structures that are unique to the virus's coat and the cells that it infects. In a paper appearin...SV virus infects lung cells, it leaves part of its coat on the cell's surface. Quantum dots have been linked to antibodies keyed to structures unique to RSV...Scientists streamline method for making key virus
...ells, the virus switches gears, acquires a protein coat for its DNA, and begins to churn out particles to ...late the complete genome of the virus in a protein coat by adding the key components of the virus -- its DNA and the protein molecules that make the virus c...Deep thinking: Scientists sequence a cold-loving marine microbe
...nty of extracellular polysaccharides (sugars) that coat cell membranes. Aside from its cellular outerwear, C. psychrerythraea generates a range of potential cold-protective compounds. One example is a family of polyesters, known as polyhydroxyalkanoate (PHA) compounds, that may also boost reserves of n...Scientists develop nanotech-laser treatment that kills cancer cells without harming healthy tissue
...tamin known as folate. The researchers decided to coat the nanotubes with folate molecules, which would only be attracted to diseased cells with folate receptors. The experiment worked as predicted. Most of the folate-coated nanotubes ended up inside cancer cells, bypassing the normal cells--like Troja...New technique could alter field of mouse genetics
...fluorescent protein and an enzyme that changes the coat color of a white mouse to grey or black. The transposon acts as a genetic beacon, so researchers can easily track its location without having to sequence the entire genome, as can happen with the chemical mutagen technique. In three months, the two ...A powerful new tool for decoding gene functions in mammals and Man
...fluorescent protein and an enzyme that changes the coat color of a white mouse to grey or black. The genes carried by the transposons have been stably inherited and expressed through five generations. "The transposon acts as a genetic beacon, so researchers can easily track its location without having to...