Gene-transcription machinery seen poised for action, held in check until needed
...rise a nucleosome, and long strings of nucleosomes coil in turn into chromatin, the basic material of chromosomes. Specific modifications to histones have been associated with either gene repression or activation. A key finding in the earlier study was that both the addition and removal of ubiquitin at di...Unraveling the physics of DNA's double helix
...uctures, Marszalek said. Single strands of adenine coil in a fairly regular fashion to form a helix of their own, while thymine chains take on a more random shape. The pure adenine strands exhibited an even more complex form of elasticity than had been anticipated, the researchers reported. As they stre...Researchers find gene that spurs development of the epididymis
...thing odd: In one specimen the normally convoluted coil of the epididymis was instead a stunted, straight tube. The lack of coiling had serious implications for the fertility of the mouse, Yao said. If you take sperm directly from the testis and put it into the female reproductive tract, it wont swim....Decoding protein structures helps illuminate cause of diabetes
... from an unordered mishmash into flat sheets, then coil into fibers. "No matter how fast they're moving, we can take pictures of them," says Zanni. Without their automated method, he says, such experiments would be nearly impossible. The technique also has potential application in other human diseas...NMR advance relies on microscopic detector
... other molecules. NMR probes normally consist of a coil that surrounds the sample being studied. The coil creates a magnetic field that interacts with the nuclear spin of atoms in the sample, and those inte...Penn researcher shows that DNA gets kinky easily at the nanoscale
...A: How can parts of such a rigid molecule bend and coil without requiring large amounts of force? According to a team of researchers from the United States and the Netherlands, led by a physicist from the University of Pennsylvania, DNA is much more flexible than previously believed when examined over ex...Gene-regulating enzyme is also a target for anti-depressive drugs
...rise a nucleosome, and long strings of nucleosomes coil in turn into chromatin, the basic material of chromosomes....Art of Science exhibit opens at Princeton
...und sculpture is a prototype of an electromagnetic coil used in an experimental fusion device. Exhibit organizers noted that the shape of the coil is a kind of mirror image to a sculpture by the famous artist Henry Moore on the Princeton campus. "...Lefties have the advantage in adversarial situations
...ils mate most effectively with snails whose shells coil in the same direction. The overwhelming majority of snail species are right-handed -- their shells coil clockwise. Dietl studied a species of snail that are lefties, and have shells that coil counterclock...New images capture virus in extraordinary detail
...lla bacteria. The photographs clearly show a long coil of DNA dangling inside the viral shell, waiting to be ejected via a protein channel just inside the shell exterior. "Now you can see the end of the DNA. You can see the cylinder holding it, poised to go into the cell," said King. To create the detai...Biologists build better software, beat path to viral knowledge
...uspects the core helps ease the release of the DNA coil into the bacterium, an event akin to shooting a spool of twine attached to a grappling hook across a wall at high velocity. But he said the impact of the team's research would likely be felt more by people who have wanted a tool to look at other viru...Unraveling the viral mechanism
...he surface shell entirely, they saw the concentric coil of DNA underneath. They also identified a protein ..., then you have trouble using it again. But if you coil the hose orderly, then it is easy to use again. I think the virus does the same thing. The virus gen...New cell transplantation technique restores insulin production in diabetics
...because of the layered applications of gelfoam and coil used to close the access site." Dr. Krishnamoorthy said that even though percutaneous islet cell transplantation is currently an experimental procedure, the sandwich closure is a safe method that prevents many of the complications common to previous ...Superconducting magnet attracts molecular research
...hough the large liquid helium tank surrounding the coil needs to be refilled every six weeks or so. Once the magnet has been fully tested, Brandeis researchers, as well as other Boston-area universities engaged in NIH-funded biomedical research, will use it around the clock. Experiments usually run in...Stimulating the brain makes the fingers more sensitive
...e finger. rTMS is applied with an electromagnetic coil in the shape of a figure-eight, placed on the scalp directly over the targeted portion of the brain. Short bursts of a strong magnetic pulse stimulate electrical currents within. Sensory input from each region of the body is represented on the surfac...Scientists get first glimpse at how plants, most animals repair UV-damaged DNA
... that contains the dimer to flip outwards from the coil and into the pocket. Then, when a photon of visible light hits the pocket, the enzyme becomes excited, and expels one of its own electrons into the dimer, which forces a rearrangement of the atoms in the DNA. "From our work, we see that in less than ...Molecular partners required for appropriate neuronal gene repression
...rise a nucleosome, and long strings of nucleosomes coil in turn into chromatin, the basic material of chromosomes. In the body's scheme for safely storing genes away until needed, DNA is tightly looped around the histones, kept secure by enzymes similar to the one studied by the Wistar team until made acc...Fundamental discovery -- bone fracture
... to absorb shock. When the stress is relaxed, they coil back to their original structure. The possible implications for human health are important, explained Georg E. Fantner, a UCSB doctoral student in physics and first author of the report. "The findings may lead to therapy for bone fracture, or ev...Scripps research scientists solve structure of a critical innate immune system protein
...e protein is described as a large horseshoe-shaped coil composed of 23 leucine-rich repeats (LRRs). The structure reveals details of TLR3 that have never been seen before, an essential step toward fully understanding the critical role this protein--and other TLRs--play in the human innate immune system t...Incubator company at NJIT develops lifesaving MRI coil for small animals
...ced today that it has begun developing a cryogenic coil to improve Magnetic Resonance Imaging (MRI) scanners. "The new coil will be well suited for animal imaging," said Supertron President Jon T. DeVries. "Small animal mod...