Estrogen protects male rats from aortic aneurysms
... called macrophages," Upchurch adds. "MMPs degrade collagen and elastin, two major proteins in the aortic wall. Typically production of MMP's are part of the body's natural healing response to injury, but left unchecked, MMPs in particular MMP-9 can cause extensive tissue damage and lead to the formation of...JCI table of contents November 1, 2004
...pulmonary fibrosis mouse model resulted in reduced collagen deposition and tissue destruction in addition to a...ted in well-defined thick layers of fibroblast and collagen matrix. Together, these data indicate that SEMA3F is a strong inhibitor of metastasis that affects b...New source for heart bypass replacement blood vessels: Fibrin-based TEVs
...arkable remodeling with considerable production of collagen and elastin, and significantly increased mechanica...ing polyglycolic acid (PGA) have shown promise and collagen gels also worked, though 7mm collagen-based TEVs needed Dacron mesh reinforcement. Prior to this st...Army-funded effort examines androgen's role in bone loss
...sensitive response to androgen." Using collagen DNA cloned from rats as a promoter, Wiren was able to drive overexpression of the androgen receptor DNA in the skeleton and at a high level. "When we characterized how much of the receptor was present, it was four-fold higher. It's higher than what y...Dinosaurs in bullet-proof vests
...isation microscope Torsten Scheyer discovered that collagen fibres were interwoven in the bone calcium of the ...bullet-proof vests except that in these cases the collagen mats are replaced by glass or carbon fibres. Collagen is a protein found in connective tissue, sine...Purdue researchers align nanotubes to improve artificial joints
... in the same direction, mimicking the alignment of collagen fibers and natural ceramic crystals in real bones.... direction. This orientation is similar to the way collagen and natural ceramic crystals, called hydroxyapatite, are aligned in bone, said Thomas Webster, an as...Patients' own stem cells used to cure incontinence
... and use of absorbents, such as adult diapers, and collagen injections, which show improvement during the first six months but often result in symptoms returning after a year. Dr. Frauscher also said the stem cell treatment appears to be more successful with women at this time. For men, incontinence is often ...Novel AT2R gene transfer prevents hypertension-related enlarged heart, cardiac fibrosis
...ormation of fibrosis an extracellular matrix like collagen -- that makes it harder for the heart to pump." Without AT2R protection, left ventricular wall thickness (LVWT) increased 123% and the heart weight to body weight ratio (measuring overall "enlargement") rose 129%. At the same time, myocardial fibros...Eating red meat may increase the risk of rheumatoid arthritis
...a predisposition for RA. "It may be that the high collagen content of meat leads to collagen sensitization and consequent production of anticollagen antibodies, most likely in a subgroup of sus...Red wine lovers, take heart: More evidence points to the drink's cardiac heath benefits
...a result, these cells produce excessive amounts of collagen a fibrous substance found in bone, tendons, ligam...connective tissues. "This hyper-secretion of collagen leads to a stiffening of the heart muscle," Bomser said. "So the heart has to work harder to pump bl...A key signaling molecule in osteoarthritis is identified
...g naturally-occurring mutant mice with a defective collagen gene, scientists at Harvard have identified a sign...nset osteoarthritis. However, the link between the collagen mutations and the pathogenesis of osteoarthritis is not clear. To further elucidate the relationship...Priming embryonic stem cells to fulfill their promise
...cluding laminin, fibronectin, and several kinds of collagen - that function as the extracellular matrix, or scaffolding, of most mammalian tissues. Until now, there has been no practical way to evaluate the daunting number of possible combinations of these proteins, any one of which could form the optimal "ni...Tufts-NEMC researchers identify enzyme that activates cancer cell growth and invasion
... means that MMP-1 is not only cutting up the tough collagen matrix that surrounds cancer cells, it is also activating PAR1 to enable the cancer to invade into other tissues." The researchers identified several cell-penetrating compounds called pepducins that block activated PAR1 from triggering cancer invasio...Signaling protein builds bigger, better bones in mice
...ls in bone marrow, MacDougald found high levels of collagen and alkaline phosphatase, and expression of transcription factors that turn on genes involved in bone formation. Bennett discovered another important clue when she found that Wnt10b expression shuts down activity of a gene called PPAR-gamma, which ...Dental researchers answer key enamel question
...at guides the formation of mineral in bone. Unlike collagen - which remains an essential part of bone structure, helping it to heal after fractures - amelogenin degrades and disappears during the process of enamel mineral growth, or biomineralization. Because its transient role makes it hard to study, ameloge...Tiny scaffolding allows stem cells to become working fat cells
... normal tissue. The fibers are about the size of a collagen fiber, several nanometers (a billionth of a meter) across, and provide tensile strength to support the growing tissue," Kniss said.The researchers then "seeded" that scaffolding with cells called pre-adipocytes cells that had begun their transformati...NC State scientist finds soft tissue in T. rex bones
...structures, or flexible matrix that resembled bone collagen from modern specimens. Current theories about fos...nary research shows that antibodies that recognize collagen react to chemical extracts of this fossil bone. If further studies confirm this, we may have the pot...JCI table of contents May 1, 2005
...ar, the researchers focus on the adipocyte-derived collagen VI and show that it is a critical factor that prom...y microenvironment in vivo. The authors show that collagen VI encourages proliferation and survival of malignant cells and mice that lack collagen VI have sign...A big fat contribution to breast tumor growth
...ar, the researchers focus on the adipocyte-derived collagen VI and show that it is a critical factor that prom...y microenvironment in vivo. The authors show that collagen VI encourages proliferation and survival of malignant cells and mice that lack collagen VI have sign......dividuals. Cells from these patients had abnormal collagen patterns. In an accompanying commentary, Francis Glorieux writes that these data "represent an important step forward in the understanding of the pathology of an elusive disorder." TITLE: Novel COL1A1 mutation in infantile cortical hyperostosis (Ca...