Normal chromosome ends elicit a limited DNA damage response
...ch ensures that each daughter cell receives a full complement of chromosomes would inevitably rip the fused chromosomes apart. "Such fusion breakage cycles scramble the genome over time, and cause genome instability, which is a hallmark of cancer cells," explains Karlseder. "This demonstrates the importance of...An insecure role for Securin in chromosome segregation
...s, is that the progeny cells must receive the full complement of chromosomes. Failure of this mechanism, which sometimes happens in cancer cells, leads to rampant chromosome loss and mutations that encourage proliferation and increase instability. Understanding how normal cells unerringly transmit a full chromo...Nerac delivers new research solution
...180 degrees to offer self-search capabilities that complement the research of our scientists and engineers," said Nerac's CEO Kevin Bouley. The technology powering Nerac 180 was custom developed by Elsevier Engineering Information (Ei). Ei has been providing end user focused web solutions for engineering res...Shade trees getting 'scorched' by plant disease
...rees, and design new tree plantings with a diverse complement of tree species. More on the symptoms of BLS and disease management options is available in this month's APSnet feature article at http://www.apsnet.org/online/feature/bls/ ....Institute for OneWorld Health hosts panels at ASTMH
...here is a need to develop and implement tools that complement the current standard treatment in developing countries of Oral Rehydration Therapy (ORT). OneWorld Health brings together a panel of clinicians and global health experts to review the current situation and practice of ORT in developing countries, an...New nanosensor uses quantum dots to detect DNA
...s made of synthetic DNA. Each of these probes is a complement to the DNA sequence the researchers are searching for. Therefore, the probes seek out and bind to the target DNA. Each DNA probe also has an important partner. Attached to one is a Cy5 molecule that glows when it receives energy. Attached to the sec...DOE Joint Genome Institute issues new call for large-scale sequencing proposals
...ory Y12 Security Complex. Sequences generated will complement biogeochemistry, hydrology, microbiology, and engineering studies to help evaluate the impacts of contaminants and remediation treatments on microbial community dynamics. The tropical grain Sorghum bicolor is expected to provide an improved bluepri...The Euroscience Open Forum 2006 announces the conference programme
...rie Lehn, as well as Erasmus awardee Sadik al-Azm, complement the programme and touch upon the most critical issues in the speakers' fields. These lectures are designed to endorse dialogue between key representatives of the sciences and the general public and will therefore be freely accessible. ESOF2006 especi...GlycoFi announces the first production of antibodies with human glycosylation in yeast
...alf-life, tissue distribution and interaction with complement proteins. Currently glycoproteins comprise about 70% of all approved therapeutic proteins and the therapeutic protein market is expected to grow at over 20% annually over the next decade. GlycoFi is now working to expand its library of glyco-engineer...Pleasing plant shapes explained by new computer model
...periments by providing a tool botanists can use to complement and interpret their traditional laboratory experiments. It also promises to lead to accurate models of how other organisms, including animals, develop from primordial stem cells. "This was a great example of the synergy you can have between biology a...Vaccine provides 100 percent protection against avian flu virus in animal study
...irus-based vaccine could be a critically important complement to them. Because it appears to be so successful in immunizing chickens against H5N1, widespread inoculation of susceptible poultry populations could provide a significant barrier to the spread of the virus via that route in this country and other cou...Airborne and satellite radars record Frascati grape harvest
...mpaign was called BACCHUS-DOC, and was intended to complement a number of radar and optical satellite acquisitions by ERS-2, SPOT, Landsat, IKONOS and QuickBird. Following processing of raw data, the results are now under study by a team from ESRIN, ESA's European Centre for Earth Observation located within t...Report lists top 20 most-vulnerable African carnivores
... at which areas in Africa have retained their full complement of large carnivore species and which areas need more conservation action. Populations of the lion, listed in the report as "most vulnerable" have dropped steadily in recent decades, primarily due to conflicts with humans, destruction of habitat, and ...New brain hormone puts brakes on reproduction
...tive system. The inhibiting or braking hormone may complement the "gas pedal" role played by another recently discovered hormone, kisspeptin, that stimulates GnRH. The discovery in rats, mice and hamsters of this new system for regulating reproduction strongly suggests that the hormone plays a similar role in t...Satellites support businesses working for sustainable development
... aspects of sustainable development. As such, they complement other ESA activities, including the TIGER Initiative for sustainable water management in Africa and the activities within the Data User Element, which focus on institutional and government aspects of sustainable development....Genomics-based vaccine could prevent deadly cattle disease
...s taken from cattle immune to East Coast fever. To complement TIGR's gene selection strategy, ILRI also incorporated a random screen of T. parva DNA for vaccine candidates. In total, the team found five candidate vaccine antigens. In lab tests, these antigens triggered a response from cattle immune killer T ...New partnership focuses on prostate cancer diagnostics
... and prognosis of prostate cancer. This work could complement or significantly improve the current PSA blood test, which suffers a lack of specificity." Through the collaboration, CPDR's oncogenes may be studied in combination with other promising prostate cancer markers owned by Gen-Probe, including PCA3 and A...HHMI awards $10 million to graduate programs that combine science and medicine
...and basic clinical training. This certificate will complement a thesis granted from any of their existing degree programs. University of Pennsylvania has proposed to develop a certificate program that will consist of three modules that present core principles that underlie medical sciences, focus on human phys...Chromosome rearrangements not as random as believed
...e in the broader structure of the genome--the full complement of DNA sequences in sets of chromosomes. Recent research by Drs. Emanuel, Kurahashi and colleagues have detected other palindromic repetitive DNA sequences at the breakpoints of other translocations, suggesting that these unstable structures may play......, those with Sry with either the XX or XY - sex complement behaved similarly, other genes on the sex chromosome also played a role in these behaviors in gonadal females. 4. Probing Myelin Protein Zero Gain ofFunction Mutants Lawrence Wrabetz, MaurizioD'Antonio, Maria Pennuto, GabrieleDati, Elisa Tinelli,...