Penn receives grant for initiative to help understand genes' effects on medications
...inctive, and sustainable approaches to solving the complex biomedical problem of variable drug response. The team will work to generate strategies targeting barriers to interdisciplinary research on three fronts: Scientific: by producing study-design and statistical techniques and methodologies aimed at s...Commandeering cellular machinery: recognition mechanism to detect small molecules
Researchers have learned how to commandeer the complex machinery that cells use to recognize and respond ... small molecules, the nuclear receptors initiate a complex process that results in gene expression. Because these receptors play a vital role in controlling c...Daphne Koller named MacArthur Fellow
...of computational methods to resolve uncertainty in complex information sets, is one of 23 individuals honored...ugh questions." She says she hopes to resolve "the complex network of interactions between many genes, proteins, metabolites and signals" using computational m...NIH funds first nationaL SNP genotyping center at Broad Institute
...genetic regions that, in humans, may contribute to complex diseases such as diabetes and hypertension. "The tremendous potential of genetic research makes it critical that we develop this central resource so investigators around the country can access high capacity genotyping with the additional benefits of ...Marine Biological Laboratory summer investigator wins Nobel Prize in Chemistry
... he later identified a specific ubiquitin ligating complex that "targets cyclin B for degradation at the end ... Today Hershko is studying that ubiquitin ligating complex in both clam eggs and cultured human cells in hopes of learning even more about cell division in gen...Forum at Virginia Tech to address issues of human cloning
... cloning is with us. Both types of cloning involve complex social and ethical dimensions that merit public discussion," says Choices and Challenges co-director Eileen Crist of the Department of Science and Technology in Society. The forum is designed both to inform and to provide an opportunity for public pa...U-M scientists see ubiquitin-modified proteins in living cells
...l." "When ubiquitin is attached to Jun, the complex is transported to the lysosome getting it away from DNA in the nucleus and preventing Jun from continuing its normal gene transcription function," he adds. "This is a new way for the cell to eliminate the function of a transcription factor." U-...Component of volcanic gas may have played a significant role in the origins of life on Earth
...y sophisticated living organisms--with cell walls, complex metabolism, and DNA genes. The question of the origins of life is: what came before the stromatolites? Research on the origins of life has suggested the notion of an ancient RNA world--one in which RNA genes stored genetic information (something ...Yale scientists find cooperative RNA switches in nature
...ns is that modern RNA has what it takes to run the complex metabolism of life. It is like what would have bee...sociated with RNA. It is also surprising that such complex relics of an RNA World are seen in modern organisms. Breaker and his research team have pioneered th...Study describes basic mechanism in cell growth control involving damaged DNA
...basic biomedical research, studies are revealing a complex molecular choreography with implications for human...echanisms controlling cell cycle progression - the complex processes by which cells divide and DNA is replicated - and how this control becomes altered during ...Cooperation to create a new tuberculosis vaccine
...o prevent the outbreak of TB after an infection, a complex cellular immune response against the pathogen has to be stimulated. In other fields, MOLOGEN has already demonstrated that its DNA vaccines stimulate the cellular immune response against infectious agents much more efficiently than other current vacc...Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2004
...ment at Princeton Plasma Physics Laboratory. Using complex computer programs and mathematical models, ORNL team members Mike Cole, Paul Fogarty, Paul Goranson, Jim Lyon, Brad Nelson and David Williamson evaluated many different concepts. The final design -- shaped like a giant, twisted doughnut -- will help ...Cells in retina found to behave like soap bubbles
...ed it to design intricate cellular patterns within complex structures such as the eye." Similar to the colored dots in a Georges Seurat painting, though on a three-dimensional scale, the cell is the indivisible unit that gives shape to something larger and recognizable -- a butterfly, a maple tree, a human ...Researchers provide road map for generating B cells from stem cells
...xpect that other cell types will require similarly complex regulatory networks for their generation." "But the work is also promising," Singh added. "Once we order the components and gain insight into the design principles of such regulatory networks we may be able to make any kind of cell we want, or even ...Acoustics meeting in San Diego
...iscuss a technique to synthesize human laughter, a complex mode of expression that varies greatly from indivi...ment the standard in new and existing schools. The complex efforts to adopt the standard in new and renovated LosAngeles schools will be discussed by Angelo Be...Rutgers-led research offers new clues in the genetic mysteries of maize
... to its immense size, the corn genome is extremely complex due, in part, to positional instability as well as its genetic history. Messing and his colleagues concluded that maize genes are scrambled, having moved around to different locations throughout the genome an occurrence unheard of in other species, ...Study in Royal Society journals presents evidence for inherited factors in homosexuality
...A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consi...Professor H Ellegren The major histocompatibility complex (MHC) has an integral role in the immune system and the high levels of variability found among its g...Touching research: How white blood cells navigate
... work are daunting, partly because each cell has a complex surface topography, with dozens of small molecular projections that give it a ruffled appearance, kind of like a tiny raisin. Those projections serve as signals that help determine where white blood cells will exit the bloodstream and fight infection...Faces age due to fat loss, skin changes - not gravity
...al fat and sun damage are more contributory in the complex process of aging." In addition, the nature of facial skin changes over time becoming thinner, most notably around the eyelids. These changes are often accelerated by sun exposure, which damages the skin. "Plastic surgeons rejuvenate the aging ......ts that once a hair cell senses that its signaling complex has been damaged, it rapidly recycles the components of that pathway so they can be reused or replaced. "So we said, look, if the tip-link protein goes away when you separate the tip links, maybe other parts of the transduction machinery will go away...