OHSU turns mouse into factory for human liver cells
...micals in the liver, and you can't predict how the compound you developed in the lab will be converted," Grompe said. "Often, it's not the drug that's toxic, but the resulting metabolites. The conversion of drugs cannot be predicted with any current technology, such as computer models. You actually have to se...Inflammation may cause preterm labor and fetal deaths
...that had TLR4 receptors but were given a synthetic compound to block the receptors inflammatory response. With.... The TLR4 group that was not given the synthetic compound to block TLR4 from reacting to bacteria had a 50% increase in fetal death over the mice that had TLR......contamination of water supplies. Both the original compound and its subsequent products are being detected in surface water and shallow groundwater. This highlights the need to determine the extent of water risks during atrazine use and to develop conservation practices to minimize negative affects....UCF research links proteins, stem cells and potential Alzheimer's treatment
...gating whether a combination of phenserine and his compound (NBI-18), which increases brain stem cells by 600 percent, could become another way to treat Alzheimers. Increasing neurons may be important in improving brain function, especially in people with neurodegenerative diseases. Sugaya tempers his enthu...Under magnetic force, nanoparticles may deliver gene therapy
...carry a surface coating of DNA bound to an organic compound called polyethylenimine (PEI). The PEI protected the DNA from being broken down by enzymes called endonucleases that were present in the cell cultures and which occur normally in the bloodstream. The DNA was in the form of a plasmid, a circular mol...Nature's weapon against nerve agents
...l problems caused by exposure to paraoxon, a model compound for nerve agents such as sarin, soman and VX. GOTs ability to protect against neurological damage, the company claims, is down to the fact it can bind to, and chemically inactivate, a chemical called glutamate, also found in the blood and brain. In...Isoprene emission from plants -- a volatile answer to heat stress
Isoprene is a hydrocarbon volatile compound emitted in high quantities by many woody plant species, with significant impact on atmospheric chemistry. The Australian Blue Mountains and the Blue Ridge Mountains in the Eastern United States are so called because of the spectral properties of the ...JCI table of contents -- July 26, 2007
...s, show that activation of LXR-beta by a synthetic compound is able to reverse atherosclerosis and cholesterol...rprisingly, however, administration of a synthetic compound that activates LXR-beta, was able to compensate for the loss of LXR-alpha, reduce cholesterol overlo...Drug protects brain cells in Huntington's disease model, researchers find
...ne or Nitoman and blocks the action of dopamine, a compound that some nerve cells use to signal others. TBZ is approved for use in several countries, but not the U.S., to treat uncontrollable muscle movements in Huntingtons and other neurological conditions. Huntingtons is a fatal genetic condition that us...Jefferson scientist's patent dramatically improves
...e pairs finding, through trial and error, that the compound lithium boric acid in DNA electrophoresis is the optimal solution for this process. -more- Faster DNA separation -- 2In electrophoresis, solutions conduct electric current necessary to separate negatively charged DNA molecules. DNA is put through j...Nature's secrets yield new adhesive material
... thin layer of a synthetic compound. This unusual compound mimics the reversible bonding action of a mussel adhesive protein that Messersmiths group has studied for the past several years. In their initial experiments, which were led by graduate student Haeshin Lee, they found that the wet adhesive force ...Research study describes the role part of the brain plays in memory
...food preference. To do so, they applied a chemical compound to the experimental rats that neutralised the acetylcholine receptors (muscarinic cholinergic receptor) of this region. By blocking the receptor, the effect of the neurotransmitter was also neutralised and the changes in the animals' behaviour were o...Cardiac patches stimulate regeneration, improve function after heart attack
...rate in rats that a sponge-like patch, soaked in a compound called periostin and placed over the injury, can not only get heart cells to begin dividing and making copies of themselves again, but also improves heart function. Their findings appear in the July 15 online edition of Nature Medicine. Periostin i...A new plant-bacterial symbiotic mechanism promising
...d genes which allow synthesis of the Nod factor, a compound elaborated by the bacterium which enables the plant to recognize it, by molecular recognition, thereby allowing the microorganism to penetrate inside the plant by the root hairs. The finding raises the question as to what signalling pathway Bradyrhiz...HWI researchers determine structure of protein from pathogen associated with CF and TB
...roteins that are essential to make pyoverdine, the compound that Pseudomonas produces to obtain iron. Some of these proteins are essential, yet the role they play is unknown. The Gulick lab has determined the molecular structure of PA2412, one of these uncharacterized proteins. The structure of this protei...Chitin from lobster shell shows great healing and bio-stimulant properties
...ose is more abundant than chitin, which makes this compound a highly important renewable resource that can easily be found in arthropods, insects, arachnids, molluscs, fungus and algae. The fishing industry in Cuba generates great amounts of lobster waste, a pollutant rich in proteins and chitin, states Pro...A compound from olive-pomace oil gets 80 percent slowing down of HIV spread
...kin, alongside oleanolic acid. The effects of this compound in the fight against AIDS are simultaneously being... properties. Maslinic acid is also a very active compound in opportunistic parasitic infections seriously affecting HIV patients. In trials carried out by t...Early environmental exposure may accelerate age-related neurodegeneration
...new study in mice. The findings also showed that a compound that protects cells in the body from damage from certain forms of oxygen, a kind of antioxidant, could suppress such neural degeneration. Previous studies indicated that both early exposure to iron and later exposure to the herbicide paraquat ind...Damon Runyon names new class of rising stars in cancer research
...sing a chemical synthesis strategy for the natural compound Cortistatin A, a novel anti-cancer drug that targets metastatic disease. David S. Matus, PhD, with his sponsor David R. Sherwood, PhD, at Duke University, Durham, North Carolina, is using a powerful genetic model to identify the gene networks that c......e current issue of Science they describe how a new compound kills fungal pathogens by blocking an enzyme cruci...of skin, nails or lungs. We have discovered a new compound that has the potential to treat common chronic nail infections caused by fungi, says Dickon Alley, r...