Tag: "congenital" at biology news
Embryonic stem cells correct congenital heart defect in mouse embryos
...ation. "In this current study, with the repair of congenital
heart defects in our Id knockout embryos, we observed that the stem cells provided normal signals to themselves and also to their neighbor cells to correct the organ as a whole," explained Diego Fraidenraich, Ph.D., the study's lead author. The resea...
Mouse study: 'Critical' Down syndrome region isn't
...ost common genetic cause of mental retardation and congenital
heart disease. "The simplistic idea that just one of the hundreds of genes on chromosome 21 affects development no longer holds up," says Roger Reeves, Ph.D., professor of molecular biology and genetics in Johns Hopkins' Institute for Basic Biomedic...
Children's Hospital Boston geneticist awarded for research on muscular dystrophy
...ly complex conditions, including autism, diabetes, congenital
heart disease, and obesity. A member of the National Academy of Sciences, Kunkel is a Howard Hughes Medical Institute investigator at Children's and Professor of Pediatrics and Genetics at Harvard Medical School....
Research team discovers possible genetic mechanism behind congenital heart defects
...ave discovered a possible genetic mechanism behind congenital
heart defects. This finding has implications for understanding how congenital
heart defects occur, and may lead to genetic tests for certain defects, such as proteins that determ...
Pediatric cardiology researchers describe findings in neurologic outcomes, heart devices
...h a heart defect, making it one of the most common congenital
defects affecting children. The Cardiac Center at ...he care of infants, children and young adults with congenital
and acquired heart disease. It is ranked as the best pediatric cardiology program in the United Stat...
JCI table of contents, December 1 2004
...bition of apoptosis improves outcome in a model of congenital
muscular dystrophy AUTHOR CONTACT: Jeffrey Boone Miller Boston Biomedical Research Institute Watertown, Massachusetts, USA Phone: 617-658-7737 Fax: 617-972-1761 E-mail: email@example.com . View the PDF of this article at: https://www.the-jci.org/pres...
New model of rare childhood blindness holds promise for testing preventive therapies
...h (MBR). The model for this disease, called Leber congenital
amaurosis (LCA), is especially important because no treatments are currently available to prevent it. There are not enough patients to enroll in large clinical trials to test new prevention treatments; therefore, any potential new therapy must have a...
...une diseases can also cross the placenta and cause congenital
heart block in the fetus. Scientists in Sweden no.... Autoantibodies had been implicated as a cause of congenital
heart block in the past, but nobody knew how they were working. This study shows that the antibodie...
Zebrafish may hold key to understanding human nerve cell development
...inical disorders including leukemia, colon cancer, congenital
heart defects, muscular dystrophy and other birth defects....
Cleft palate research receives 200,000 award
...ally, the more we can begin to analyse how and why congenital
malformations such as cleft palate occur." Dr Dixon, who was recently appointed to a Lectureship in Basic Dental Sciences, has been awarded more than 200,000 to carry out her studies. She was one of just 21 successful applicants to be funded by the s...
Recognizing new aneurysm syndrome can save lives
... severity, and some other abnormalities, including congenital
heart and brain defects and skeletal abnormalities such as early fusion of the bones of the skull or curvature of the spine, are seen in some patients. "It's too soon to know how common or rare the syndrome might be," says Dietz, "but we know that su...
Heart specialists call for cardiovascular screening for all young competitive athletes
...omyopathies, premature coronary artery disease and congenital
coronary anomalies." He said it was not sport that directly caused the deaths, but rather that it triggered cardiac arrest in athletes with underlying diseases predisposing them to life-threatening ventricular arrhythmias. The consensus group was als...
PET/MRI scans may help unravel mechanisms of prenatal drug damage
...rgeries, which are becoming more common to correct congenital
malformations, the mother is treated with narcotics for pain--and anesthesiologists are relying on the mother transferring the pain medication to the fetus via the placenta. But we actually do not know if what we give is sufficient to 'satisfy' the p...
Physicians recommend screening for toxoplasmosis for all pregnant women, newborns
...t in more than half of the mothers of infants with congenital
toxoplasmosis in a national study of children with...s during prenatal visits, as well as screening for congenital
toxoplasmosis in all newborns, become standard medical practice. The group also emphasizes that conf...
UCSD team discovers specialized, rare heart stem cells in newborns
...m five newborn human babies undergoing surgery for congenital
heart defects. Study author Sylvia Evans, Ph.D., a member of the UCSD Institute of Molecular Medicine (IMM) and professor of pharmacology, and co-first author Alessandra Moretti, Ph.D., IMM member, explained that the cells are programmed to become s...
Researchers find new technique to identify fetal genetic material from amniotic fluid
...amniotic fluid to test for hereditary diseases and congenital
defects in the fetus). "After extraction from the normally discarded fraction of amniotic fluid, RNA was amplified twice, labeled, and analyzed using gene expression microarrays." The researchers were able to study the expression of developmental...
Mechanical tension helps shape lung development
... compressed and cannot develop fully, often due to congenital
diaphragmatic hernias, which occur in 1 of 2,500 births. Kourembanas is directing an NIH-funded project on the pathology of lung development, of which Ingber is a part. "Don's work gives us an understanding of how normal lung growth occurs, and give...
Defining male and female
...sex assignment. Baby girls with a condition called congenital
adrenal hyperplasia (CAH), for example, may undergo clitoroplasty to reduce male-looking anatomy, as well as vaginoplasty if the labia are fused together. "The U.S. Constitution promises equality, rights and benefits for all citizens," Becker noted...
Kids with chronic illness face difficult transition to adult care
...nces ensured an unprecedented number would survive congenital
conditions that until recently would have killed t...ts such as cystic fibrosis, sickle cell disease or congenital
heart conditions. Many adult practitioners tend to work more independently and are less familiar wit...
Determining the fate of cells in the human body
... "From a pediatrics perspective -- there are many congenital
defects - holes in the heart, cleft pallet, webbed hands -- which are outcomes of inappropriate molecular programs due to miscommunication at the cellular level. If we can understand what is going wrong, we may be able to correct these problems befo...
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