New therapy for specific form of leukemia
...ion. It is crucial that kinases function in a very controlled manner within our cells. Loss of control of their functioning disturbs the normal functioning and division of cells. Thus, such disorders in the functioning of ABL1 are a major cause of certain forms of leukemia. Existing drug now used with T-ALL pa...DNA sequence controls expression of gene involved in cancer
...nd posttranscriptionally. One way bcl-2 levels are controlled is through an adenine and uracil-rich sequence of nucleotides in the 3' untranslated region of the bcl-2 mRNA. This sequence, called the AU-rich element, or ARE, recruits a number of proteins that destabilize the bcl-2 mRNA, resulting in its degradat...Plants provide model for new shape-changing materials
...signers also need a material with a surface that's controlled by sensors and electrical conductors that allow it to do that sensing and change shape accordingly. Properly engineered nastic materials might allow sensors that can be flexed. Don Leo, professor of mechanical engineering and a member of the Center f...Below the surface: New clues to plant signaling from the roots
...elopment. Although the growth-inhibiting substance controlled by BYPASS1 has yet to be identified, the authors show that it is different from previously identified plant hormones or signaling molecules and report evidence that it may be a novel carotenoid. ...September/October 2004 Annals of Family Medicine tip sheet
...gnificant differences in the number of arrests for controlled substance or liquor violations (0 vs. 8). The authors suggest that these compelling findings point to the efficacy of brief counseling one of the most important therapeutic modalities used by physicians. With alcohol-related mortality still the most...U-M scientists see ubiquitin-modified proteins in living cells
...to discover new information on how Jun turnover is controlled in cells," Kerppola says. The technology uses complementary fragments of a fluorescent protein, which are fused to ubiquitin and to the target protein being studied. When ubiquitin is linked to the target protein, the fragments of the fluo...Children's Hospital Boston wins $2.5 million in health surveillance grants
...ecognized expert on biosurveillance and personally controlled health records. The second grant, of $1 million, will focus on advanced technologies for investigating and managing disease outbreaks and was awarded to Dr. Aneel Advani, a new CHIP investigator in informatics and infectious disease. Advani will dir...Study in Royal Society journals presents evidence for inherited factors in homosexuality
...ers and breeders are of similar size. We show in a controlled laboratory experiment that helpers reduce this risk of eviction by maintaining a 'safe size difference' with the breeders: they grow slowly when helping small-sized breeders and grow quickly when helping large-sized breeders. We discuss whether this ......elp us identify the target genes that are normally controlled by TR4 and contribute to regulation of specific behaviors," she adds. Scientists have known that the receptor is present throughout tissues such as muscle, spleen, thyroid gland, the testes, and the cerebellum, but they didn't expect that knoc...Delay in cutting the cord helps premature babies
...s as they grow up. She is conducting a randomized controlled trial funded by the National Institutes of Health of early versus later clamping times in 74 preterm babies. In this study, the infants will be followed until they are 7 months old when developmental testing will be done. Eventually, she hopes to tr...New version of tumor-suppressor linked to progression of childhood cancer
...lting from altered splicing of TrkA transcripts is controlled in part by hypoxia, a condition where cells are deprived of oxygen that is known to contribute to cancer progression. The researchers found that TrkIII stimulated advancement of NB, in part, by interfering with the normal anti-oncogenic function of T...Incentives for US farmers reduce water waste
...onservation of water. Water pollution needs to be controlled to protect public health, agriculture and the environment. Other authors of the BioScience report were students in Pimentel's graduate-level class, Environmental Policy: Bonnie Berger, David Filiberto, Michelle Newton, Benjamin Wolfe, Elizabeth Kara...Yale professor named 2004 Biomedical Engineering Society Distinguished Lecturer
...ashioned biocompatible polymeric materials for the controlled delivery of drugs, proteins, and genes, and they have created polymer implants to promote the regeneration of diseased and traumatized tissues in the nervous system and to enhance the survival of transplanted cells and tissues. The annual award recog...Three years of Proba, the 'smart' satellite that runs itself
...es because Proba is maneuverable enough to perform controlled pitch and roll. That combined ability to retrieve hyperspectral and multi-angular data makes it especially useful for the study of land vegetation cover. It is also useful for studying the atmosphere and bodies of water. Around 60 scientific teams w...Soaking up signal: Endocytosis controls spreading and effective signaling range of Fgf8 protein
...chanisms by which the spreading of Fgf8 protein is controlled in a field of target cells are unknown. In seeking...nd that spreading of Fgf8 through target tissue is controlled by endocytosis--i.e., internalization of Fgf8 protein by the cell--and subsequent degradation of Fgf...Clues to the puzzle of 'talking' root cells
...id interior -- or whether transport occurred via a controlled process. To follow the transport of the protein, Benfey and his colleagues used a tracer molecule that enabled them to pinpoint the Short-Root protein in living root cells. These studies indicated that in the cells from which the protein moves,...Stimulating nerve cells with laser precision
...have brought the day when artificial limbs will be controlled directly by the brain considerably closer by discovering a method that uses laser light, rather than electricity, to stimulate and control nerve cells. The researchers have discovered that low-intensity infrared laser light can spark specific ner...VYTORIN (TM) superior again to Lipitor at lowering LDL (bad) cholesterol
...as a multicenter, randomized, double-blind, active controlled parallel-group study of 1,902 patients designed to...nt for patients treated with VYTORIN 10/80 mg. In controlled long-term (48 week) extensions, which included both newly-treated and previously-treated patients, t...Gene found to defend against environmental pollutants and pulmonary emphysema
...oke, the researchers were able to learn which gene controlled this natural defense mechanism. The researchers found that disruption of the Nrf2 gene caused earlier onset and more severe emphysema in a strain of mice that is resistant to cigarette smoke-related emphysema.Through gene chip analysis, the researche...Bristol scientists find key to unlock body's own cancer defence
...ended periods of time. This blood vessel growth is controlled by many factors, but VEGF is the most powerful factor. Dr Bates, said: "Now that we have found out that this protein works in living tissues, we need to find the best way of using it in cancer, with tumour models. We also need to try it in models of ...