DNA sequence controls expression of gene involved in cancer
...e discovery of a new region on the bcl-2 gene that controls its expression may be big news for cancer therapy. Several drugs that reduce the amount of bcl-2 present in the cell are already used in chemotherapy to induce apoptosis and overcome drug resistance in cancer cells....Study describes basic mechanism in cell growth control involving damaged DNA
...sources of UV radiation, especially sunlight."CDT1 controls DNA replication, making sure DNA replicates once and only once," said Xiong. "But after replication, CDT1 must be degraded to prevent re-replication before the cell finishes dividing. "And when DNA is damaged, the cell must find a way to very rapidly...New method identifies chromosome changes in malignant cells
... biologists often look for a master regulator that controls them all at once. "They can write whole papers about how interesting it is that they are regulated together, when in fact what is happening is that the whole chunk of the chromosome containing those genes has just been amplified." The work also may ...Study using robotic microscope shows how mutant Huntington's protein affects neurons
...dish to images it has stored and to manipulate its controls to look at the same neurons over and over again - like time-lapse photography. This allowed the investigators to follow changes in a single neuron or a group of neurons over a period of days. They used this automated microscope to study neurons tha...Time-lapse movies show brain cells move like a two-stroke engine
...ng neurons to the brain's cerebellar cortex, which controls movement and balance, continues until a child reaches the age of two. Serious disorders ranging from the epilepsies to cortical malformations result if the process goes awry, and the brain's proper architecture does not develop. Neurons are produced ...Scientists identify new cause of obesity
...central role in the "feast or fast" signaling that controls the urge to eat has now been found to influence ap... involved in the much-studied brain signaling that controls appetite. Rather it maintains the protein's intrinsic activity. The effort to tease apart the networ...Lag-3 gene dampens immune responses by controlling regulatory T-cell function
... Lag-3 is a key protein on regulatory T cells that controls effector T cell function. "The tumor-specific T cells generated by some anti-cancer vaccines are not very effective because regulatory T cells block their therapeutic activity," said Creg J. Workman, Ph.D., a postdoctoral researcher in Vig...Early life stress harms mental function and immune system in later years
...resses during the last third of their pregnancies; controls in this group were left alone. Adult female offspring were then given an intravenous injection of lipopolysaccharide, an immune challenger known to bring about stress and immune responses. The adult offspring were sacrificed at either zero, one, or t...Nitric oxide is essential for animal development
...lood pressure, contributes to the immune response, controls neurotransmission, and participates in cell differentiation; in fact, the list of the physiological functions for which NO action is important continues to grow. Nonetheless, it has long remained an open question whether NO is also actually necessary...Yerkes researchers to present array of new data at Society for Neuroscience Meeting
...y of the basal ganglia, a region of the brain that controls motor function. This finding sets the stage for further analysis of the role of these proteins in the development of Parkinson's disease. (5 pm 8 pm.) October 25, 2004 Each study is embargoed until the date and time of presentation. Symposium ...Novartis receives European marketing authorization for Emselex(R)
...by selectively inhibiting the detrusor muscle that controls bladder contraction while sparing the M1 and M2 receptors believed to be involved in central nervous system (CNS) and cardiovascular (CV) function, respectively. (1) Emselex has been shown to reduce the number of weekly incontinence episodes by up t...UCSD biologists discover chemical important in guiding visual system development
...eir evidence that the chemical messenger adenosine controls the timing of these bursts of electrical activity. Knowing what triggers these waves of activity could make it possible to recreate them for therapeutic purposes, they said, and may shed light on disorders caused by their disruption. "The wav...UCLA and Univ. of Utah researchers identify how a hormone regulates iron
..., researchers discovered that the hormone hepcidin controls ferroportin, an iron-transporting molecule on the surface of specific cells that contain iron. Hepcidin signals ferroportin not to release iron into the blood stream. Researchers realized that if there isn't enough hepcidin to regulate ferroportin...Reed biology professor receives $227,500 for E. coli research
...inue studying how the master regulator protein LER controls the disease process on the molecular level. The long-term goal of the laboratory is to use this knowledge to develop effective therapeutics for the treatment of this and related infections. In the United States, EHEC, a pathogen related to EPEC, is o...Gene found to defend against environmental pollutants and pulmonary emphysema
...tions have identified a "master gene" in mice that controls the action of 50 other genes whose products protect the lungs against environmental pollutants. The researchers believe their findings will provide a better understanding of the human body's defense mechanisms and could lead to the identification of ...Researchers tracking sources of arsenic contamination in water
...id. "We are trying to determine the biogeochemical controls on arsenic release. In this case, release was accelerated through human activity (mining). But we are also looking at how the mineral weathers; then, once it is in the water, how it interacts with the sediment and with bacteria." Since much of the ar...Stem Cells: Saving Lives or Crossing Lines?
...d Embryology Authority, the regulatory agency that controls human embryonic stem cell research in the U.K. Speakers from NBC News, 60 Minutes (CBS), National Institutes of Health, Harvard Business School, Cogene Biotech Ventures, Princeton University, Research!America, Michigan State University and other inst...Research confirms that vCJD prions can be removed from blood
...ed blood, was found to have scrapie. Of the three controls where scrapie was confirmed, only two had previously displayed clinical symptoms of the disease. No animals in the test arm had any clinical signs of the disease. "This latest research further confirms results from previous infectivity studies where...Sexual competition drives evolution of a sex-related gene
...nogelin, a major protein in the seminal fluid that controls the viscosity of semen immediately following ejaculation. In some species of primates, it allows semen to remain quite liquid after ejaculation, but in others, semenogelin molecules chemically crosslink with one another, increasing the viscosity of s......ogrammed DNA break at a specific genomic site that controls mating type, the yeast equivalent of gender. W...ce, has identified a new imprinting mechanism that controls sexual switching in yeast. The French group has now demonstrated that the genomic DNA at the mat...