Joslin's new textbook is leading source for advances in diabetes care
...etes research and treatments. With the first 5,000 copies selling in less than two months, the book is now in its second printing -- demonstrating an enthusiastic market for this comprehensive guide. "Dramatic advances in the laboratory and the clinic are revolutionizing our understanding and the care of di...Several minute intermediate stage in virus-cell fusion discovered; opportunity for drug development
...ing the 'host' cell into a factory to produce more copies of the virus, which then spill out to invade other cells in the body. Scientists had assumed that once a virus begins fusing with a cell's membrane, infection of the host cell was inevitable. Thus, antiviral drug development has largely focused on pr...Researchers create infectious hepatitis C virus in a test tube
...it takes over the machinery of a host cell to make copies of itself. Much about the life cycle of HCV remains poorly understood because scientists have been unable to reproduce an infectious form of HCV that they can observe in cell cultures. The method developed by Rice and his colleagues, including scient...Immune cells' genetic 'jam session' is controlled by cell division machinery
..., halting the jam session. At the same time, other copies of Skp2 are causing the destruction of another protein in order to take the brakes off the DNA copying machinery. "This is the first evidence showing that a protein that controls regular cell division also controls an exclusive kind of recombination...Other highlights in the June 15 JNCI
...hat predisposes a person to renal tumors when both copies of the gene are inactivated. BHD syndrome is caused by a mutation in at least one copy of the BHD gene. People with BHD syndrome were found to have a sevenfold higher risk of renal cancer compared with the general population. Cathy D. Vocke, Ph.D., o...'Jumping genes' contribute to the uniqueness of individual brains
...ytes, were unaffected. At least in the germ line, copies of L1s appear to plug themselves more or less randomly into the genome of their host cell. "But in neuronal progenitor cells, these mobile elements seem to look for genes expressed in neurons. We think that's because when the cells start to different......and is manifested only in individuals carrying two copies of the mutant allele. The locus responsible for Van Buchem disease was previously mapped to the short arm of human chromosome 17 near the gene sclerostin (or SOST ), whose protein product functions as a negative regulator of bone formation. Mutat...Most common lung cancers may begin in newly discovered cells
...novel type of lung cell that can divide into fresh copies of itself and into the two more specialized kinds of cells deep in the lung. Their experiments show that at the earliest stage of tumor development, the stem cell appears to be the first lung cells that respond to a cancer-causing mutation. The newly...Study strengthens link between Foxp2 gene and language development
... engineered mice with either one or both disrupted copies of Foxp2 in order to examine the role of this gene...evelopment at Mount Sinai. Mice with two disrupted copies of Foxp2 had a complete absence of USVs, while mice with one disrupted gene emitted USVs at a signif...Saturated fats combined with genetic trait implicated in development of type 2 diabetes
...20 percent of type 2 diabetic Caucasians carry two copies of this polymorphism in their genes compared to only 10 percent in the non-diabetic Caucasian population." The researchers say this discovery opens up the distinct possibility of specific genetic screening of people at risk for type 2 diabetes, which...National Academies advisory: June 29 public briefing on ionizing radiation
...02-334-2138 or e-mail news@nas.edu >. Advance copies of the report will be available to reporters only beginning at noon EDT on Tuesday, June 28. THE REPORT IS EMBARGOED AND NOT FOR PUBLIC RELEASE BEFORE 11 A.M. EDT ON JUNE 29....Stolen gene allows insect virus to enter cells
...e." Blissard and Lung found messenger RNA (mRNA) copies of the gene in fruit fly cells, as well as F prote...roviruses had sprinkled host genomes with multiple copies of the f gene, a baculovirus picked it up through recombination. Unlike retroviruses, baculoviruse...LSU scientists develop new theory about human genome evolution by tracking 'stealth' DNA elements
...has led to the generation of more than one million copies of Alu elements in the human genome, making them the most abundant type of sequence present. Because Alu elements are so abundant, comprising approximately 10 percent of the total human genome, they have been thoroughly examined and characterized in ...North & South American researchers find architectural abnormalities in T. cruzi ribosome
...e subunits. After a string of messenger RNA (mRNA) copies the information encoded on a gene, it enters a sea of ribosomes, where that genetic information is translated into a protein product. Scientists have long known there was something strange about the genetic translational machinery of the Chagas para...Scientists identify novel gene driving the growth and survival of melanoma cells
...umors, the scientists observed as many as 13 extra copies of the MITF gene in 10 percent of primary melanomas and 21 percent of metastatic tumors. When they checked the treatment outcomes of the patients from whom the tumor samples were taken, researchers found poorer 5-year survival rates among patients wh...How HIV disables the cells' call for help
... strand of RNA, then forces the cell's DNA to make copies of it. Newly minted viruses created by the host DNA later break out of the cell membrane to infect other cells. Many believed that the very act of breaking into T cells and hijacking their DNA was enough to destroy the ability of these cells to call ...Protein amplification in melanoma is possible drug target
...l DNA replication process is altered, causing many copies of the gene to be produced instead of a single copy of a region of a chromosome. The researchers found that the MITF (microphthalmia-associated transcription factor) master regulator is the target of gene amplification in melanoma. MITF amplification...Elevated temperature enhances success of viral cancer therapy
...rst and die. The virus is modified so that it only copies itself in tumor cells and is safe for normal cells. In clinical trials, ONYX-015 was a successful therapy for many cancer patients, but the success varied considerably for reasons that were not well understood. Dr. Clodagh C. O'Shea and colleagues fr...New technique rapidly detects illness-causing bacteria
...f DNA from a sample and add enzymes that make many copies of the DNA. Duplicating or "amplifying" the DNA makes a pathogen easier to detect. The new process starts with genetic material that is extracted from a food sample. This material, called ribosomal RNA (rRNA), is responsible for translating genetic......ese proteins, and after binding to the cell, seven copies of it assemble into a specific complex that is capable of forming a pore in a cellular membrane. The pore permits the other two proteins, lethal factor (LF) and edema factor (EF), to enter the cell interior, where the factors interfere with metabolic...