New gene marker may identify need for intense AML therapy
...vels are determined by measuring the number of RNA copies of the gene that are present in cells. A high number of RNA copies indicates a high level of gene activity; a low number indicates low gene activity.) The study exami...US Surgeon General urges Americans to know their family health history
... Initiative. In the past year, more than 360,000 copies of the original "My Family Health Portrait" comput... HHS Web site. In addition, more than 85,000 print copies of the tool have been distributed nationwide. "Building on the foundation laid by the Human Genome ...Two genetic traits giving Africans malaria protection lose effectiveness when they occur together
...le disease, which occurs when someone inherits two copies of the sickle gene, one from each parent.) Studies have shown that when children with the sickle trait are exposed to malaria, they suffer far fewer parasites and are 90 percent less likely to be hospitalized by a malaria infection than those withou...Scientists observe how a close bond activates the immune system
...rts multiplying, eventually producing thousands of copies of itself. These T cell clones are capable of killing invaders outright and marshaling other cells to destroy them. In the new study, Gabriele Campi, a graduate student in Dr. Dustin's laboratory, and Kaspar Mossman, a graduate student of Dr. Grove...New technique multiplies life span in simple organisms
... of Letters, Arts and Sciences. Rather than adding copies of SIR2 to yeast, Longo's research groupdeleted the gene altogether. The result was a dramatically extended life span - up to six timeslonger than normal - when the SIR2 deletion was combined withcaloric restriction and/or a mutation in one or two ge...Researchers find pathways linking caloric restriction to aging process
... can't delete the gene entirely. But mice have two copies of the TOR gene, which means the researchers can knock out one copy, essentially cutting activity on the TOR pathway in half. They can then study the lifespan of those mice compared to others, and also look at the progression of age-related condition...'Sex' helps bacteria cope with a changing world
...e of new genes in animals, gene duplication, where copies of genes are made by accident and then altered over time. To test why these new genes were needed by E.coli, the researchers cross examined dozens of E.coli's closest bacterial relatives to see which genes were most commonly exchanged between them. ...Figuring out the ups and downsand sidewaysof neural development
...viding chromosomes in the nucleus and drag the two copies apart, ensuring that each daughter cell has its fair share. In an article in the November 23, 2005, issue of Neuron, Mihaela igman and colleagues have pinpointed a key regulator of spindle orientation in mammals. They drew on discoveries made in the ...Deleted genes help predict outcome in a children's cancer
...curs almost always in tumors not showing amplified copies of the MYCN gene. "Children known to have MYCN amplification are more likely to already be receiving the most aggressive therapy," said Dr. Maris. "However, it is important to look for 1p36 LOH and unbalanced 11q LOH in children with localized disea...Study links progressive aphasia syndrome to prion gene
...mal cellular processes. People normally have two copies of every gene. In the new study, Dr. Mastrianni and his colleagues found that almost 85 percent of the people with PPA who took part in this study had one copy of the prion gene coding for the methionine variant and the other coding for valine. "Th...New book on rain forests, slash-and-burn agriculture
...s" is published by Columbia University Press. Hard copies are $79.50; paperback copies are $39.50....Molecule links Down syndrome to Alzheimer's
...l retardation. It is caused when a child has three copies of chromosome 21, rather than the usual two. One of the genes on chromosome 21 encodes a transporter that pumps the molecule myo-inositol into the brain. The increased levels of myo-inositol in the brains of people with Down syndrome could be explai...Unexpected link between gene in liver and iron overload
...d. Furthermore, they added, people with two mutant copies of the gene suffer from severe juvenile hemochromatosis. The findings, therefore, have potential significance for the treatment of iron overload, Deng said. "Several genes cause hemochromatosis, but in all cases, hepcidin levels are down," he said. "...Learning about sex from an elegant worm
Most cells in the body contain two copies of every chromosome, one from each parent. Sex involves gently scrambling the genetic material of the chromosomes to produce variations within each species, creating individuals variously equipped to meet life's challenges. The secret of sex is meios......ldren had a variation in at least one of their two copies of the TNF-alpha gene. The team based the paper on...rs began looking at TNF-alpha. Each person has two copies of the TNF-alpha gene. In one important spot on the gene, some people have the base known as "G"; ot...New methods offer insight into regulatory DNA
...illion base-pairs of chromosome 21 sequence: three copies of chromosome 21 lead to Down Syndrome. The third was a region of chromosome 20 10 million base-pairs that is known to be associated with diabetes and obesity. In comparison with gene sequences that contain the instructions to make proteins, regula...Researchers quantify more noise in gene expression
...ering. "Many individual genes produce less than 10 copies of regulatory messenger molecules, which is such a...rescence gene pair in experiments with one to five copies of the gene pair per cell, the team was able to measure the extrinsic-noise floor, a parameter that ......id. "We subsequently found that patients with two copies of one version of the UGT1A1 gene had few side eff...version had more difficulty, and patients with two copies of the alternative version were at high risk for severe side effects. "So relying on one standard ...A year on from the Asian tsunami, satellites are aiding regional rebuilding
... in electronic form, a thousand waterproofed-paper copies of the map were delivered to the UN HIC for local ...eeds, is one reason for the map's popularity. Some copies have even gone astray from their official owners, and ended up for sale at high prices in local mark...Little known DNA repair enzyme may be a tumor suppressor gene
...rally have the ability to make completely accurate copies of strands of DNA, in certain situations damaged areas, called lesions, can bring this replication machinery to a complete halt. In the last few years, scientists have learned of the existence of a variety of so-called lesion-replicating polymerases ...