News tips from the Journal of Neuroscience
... were upregulated in the dorsal horn of the spinal cord after injury and were expressed only in microglia. The complement cascade culminates in C5 and C5a receptor (C5aR) activation and formation of the membrane attack complex (MAC). Both C5 and C5aR were upregulated dramatically after injury. Mice lackin...UCLA scientists produce functioning neurons from human embryonic stem cells
...e impulse-conducting cells in the brain and spinal cord - from human embryonic stem cells. However, the percentage of neurons in the cell culture was not high and the neurons were difficult to isolate from the other cells. UCLAs Yi Sun, an associate professor of psychiatry and biobehavioral sciences, a...New UD tissue-engineering research focuses on vocal cords
...al cords in 1997. Engineering pliable, new vocal cord tissue to replace scarred, rigid tissue in these p...isciplinary research team in determining how vocal cord cells respond to mechanical forces, which is the first step in engineering functional vocal cord tis...Stem cell therapy rescues motor neurons in ALS model
... is that while the motor neurons within the spinal cord are protected by the growth factor, their ability ...monstrated an affinity for the areas of the spinal cord where motor neurons were dying. According to Svendsen, the cells migrate to the area of damage where...JCI table of contents -- July 26, 2007
...in our understanding of tissue damage after spinal cord injury Acute spinal cord injury can damage spinal cord tissue and result in loss of functions such as mobility or feeling. In...U-M team identifies gene that regulates blood-forming fetal stem cells
..., that fetal blood-forming stem cells in umbilical cord blood behave differently than adult blood-forming stem cells after transplantation into patients. Now a U-M team led by Sean Morrison has identified the first known gene, Sox17, required for the maintenance of blood-forming stem cells in fetal mice...Scratch no more: Gene for itch sensation discovered
...eceptor found in a very small population of spinal cord nerve cells where pain and itch signals are transm...ponsible for itching in the brain or in the spinal cord until now." In fact, Chen's team became interested in GRPR because they were looking for genes in th...News tips from the Journal of Neuroscience
...conditioned WT mice extended axons into the spinal cord after a dorsal column injury, but axons in ATF3 transgenic mice did not. Similarly, ATF3-expressing neurons were unable to overcome myelin inhibition. Thus ATF by itself did not completely recapitulate the benefits of preconditioning. Making Syn...Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
... increases the bodys ability to repair the injured cord leading to permanent recovery from injury, accordi...eviewed journal PLoS ONE. Since repair of damaged cord directly correlates with prevention of paralysis, this research demonstrates that conventional clini...News tips from the Journal of Neuroscience
...ge J. Markelonis, and Tae H. Oh Traumatic spinal cord injury (SCI) leads not only to neuronal loss, but ...ntusion injury at T10/11 in adult rats, the spinal cord showed elevated levels of proNGF (nerve growth factor). Phosphorylated p38 protein-activated mitogen...Tiny tweezers and yeast help St. Jude show how cancer drug works
The annoying bulges of an over-wound telephone cord that shorten its reach and limit a callers motion help to explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators at St. Jude Children's Research Hospital and Delft University of Technology. Using...Complex ART procedures more likely to lead to umbilical cord abnormality
...roduction procedure, the more likely the umbilical cord develops in an atypical place or have other abnor...in pregnancies, was the first to examine umbilical cord abnormalities in such a large population. For many years, scientists have known that both singleto...Cord blood may preserve insulin levels in children with type 1 diabetes
GAINESVILLE, Fla. -- Umbilical cord blood may safely preserve insulin production in ch...rmine whether it is feasible to use a patients own cord blood stem cells to neutralize the bodys autoimmune attack on the pancreas and help restore the orga...Stem cell licensing deal positions Toronto as world leader in technology
...pany, will exclusively license its human umbilical cord perivascular cell (HUCPVC) technology to Stem Cell...ar mesenchymal stem cells from the human umbilical cord and we are extremely pleased to now be able to provide this opportunity to parents across the U.S., ...A faster way to recover from chemotherapy and marrow transplant
...for a marrow match, patients can receive umbilical cord blood, which also contains blood stem cells. But the number of stem cells in one cord of blood is often not adequate for older children and adults, leaving them with diminished immune fu...AAAS decries latest stem cell veto
...s for devastating conditions like diabetes, spinal cord injuries, and Parkinsons disease. The bill would m...s for devastating conditions like diabetes, spinal cord injuries, and Parkinson's disease. The bill would mandate that such research be allowed to compete f...News tips from the Journal of Neuroscience
...central projections of sensory axons in the spinal cord bifurcated normally in mice lacking Slit1/Slit2 or Robo1/Robo2, one branch consistently overshot the dorsal entry zone (DRZ) and prematurely grew into the spinal cord. This defect apparently arose from loss of negative or repulsive signaling by DRZ-e...Hot on the TRAIL of controlling inflammation in bacterial meningitis
...ay be of use to control inflammation of the spinal cord and brain, which causes brain cell death in this l...protective membranes covering the brain and spinal cord and is caused by infection with the bacterium Streptococcus pneumoniae. The observed swelling of the...JCI table of contents: June 14, 2007
...ay be of use to control inflammation of the spinal cord and brain, which causes brain cell death in this l...protective membranes covering the brain and spinal cord and is caused by infection with the bacterium Streptococcus pneumoniae. The observed swelling of the......bamer, Karin Pernold, and Lars Olson After spinal cord injury (SCI), physical and molecular barriers inhibit axon regeneration. These impediments arise in part from a glial scar consisting of reactive astrocytes as well as astrocytic release of growth inhibitors such as chondroitin sulfate proteoglycans....