Discovery might improve design, effectiveness of anti-cancer drugs
...have made a discovery that they believe eventually could help improve such drugs' design and effectiveness. The scientists have shown that the enzyme protein can be made to "fly through the vapor phase" -- from which solvent water is totally absent -- without changing its structure. When a solution contain...Manipulation of epigenome turns off as many genes as it turns on
...e hanging on to them. If these extra methyl groups could be removed, the thinking has gone, the gene could be restarted and the cancer slowed or stopped. But the new work shows that while the agents teste......logy Department documented a woman known as GW who could see colours like purple and blue in response to pe... Although many people claiming to have such powers could be charlatans, it is also conceivable that others are born with a gift of synaesthesia. "G...Urine testing might prove to be an alternative screening test for cervical cancer
... infrastructure, a urine-based approach to testing could have a huge impact." ...High fiber intake reduces estrogen levels in Latina women, according to researchers
...ls have been linked to breast cancer, this finding could provide a significant step toward preventing breast cancer. Their findings are being presented at the American Association for Cancer Research (AACR) third annual International Conference on Frontiers in Cancer Prevention Research in a poster prese......eoarthritis include age and family history. If we could understand the molecular mechanisms that create and maintain articular cartilage, it might be possible to discover what goes wrong in our joints as we age and to find better treatments for arthritis. Embryologists have already discovered quite a bit ...Gene linked to greater risk of heart disease in type 2 diabetes
...edicine at Harvard Medical School. "This knowledge could potentially lead to drugs or other methods that affect this pathway, reducing risk of heart attack and stroke in these patients." An estimated 18 million people in the United States have type 2 diabetes. People with diabetes are two to four times mo...Other highlights in the October 20 JNCI
...exate. To see if intrathecal carboxypeptidase G 2 could be used to treat accidental overdoses of intrathecal methotrexate in humans, Brigitte C. Widemann, M.D., of the National Cancer Institute, and colleagues administered the enzyme to seven patients 3 to 9 hours after an accidental overdose. Symptoms fr...Lag-3 gene dampens immune responses by controlling regulatory T-cell function
... cells and microorganisms. The finding could form the basis for new strategies for improving th... of anti-tumor effector cells. This braking action could inhibit an immune system attack on cancer cells. "This study adds to the mounting evidence that regu...Globetrotting pollutants turn up on Toronto street
...dstorm in the Sahara in Toronto air, findings that could someday give regulatory agencies an idea of who is...hey build up a library of particles, this research could make it possible to identify pollutants without any knowledge of their origin. ...Gene-altered mouse is model for rare autoimmune syndrome
...es. Also, the researchers found that they could induce symptoms of the syndrome in normal mice by ...ce. Bone marrow is the source of immune cells that could cause the disorder. The researchers' experiments with the Id3-deficient mice also revealed that T ce...Study in Royal Society journal on how relationship status influences sex ratios
...ments can affect the human sex ratio at birth, and could explain the fall in the proportion of male births in some developed countries over the past thirty years.Contact: Dr Karen Norberg, National Bureau of Economic Research, 1050 Massachusetts Avenue, CAMBRIDGE, MA 02138, USA Obtain...Leading scientists to discuss research applications for therapeutic cloning
...tes and warning that a ban on all cloning research could simply move the science offshore or to privately funded efforts not subject to U.S. regulation. Responsible clinical trials also need to be held soon, perhaps by 2008, Dr. Schatten adds....Large-scale forces shape local ocean life, global study shows
...practical: These invertebrates can't move, so they could be counted. And rock walls can be found from the poles to coral reefs and leave few places for creatures to hide, so estimates would be comparable and highly accurate.To get a true snapshot of the diversity of these species around the world, Witman a...ORNL system eliminates perchlorate, helps scientists trace source
... is natural or man-made. This latter application could be instrumental in tracking environmental perchlor...from public health issues to huge liabilities that could be imposed by agricultural and environmental cleanup needs," Gu said. "It recently has been found in...Neurosurgeons identify growth of new adult brain cells, possible treatment for epilepsy
...n in the brains of adults with epilepsy and say it could lead to ground-breaking treatment for the disease. William Bingaman, M.D., a neurosurgeon from the Cleveland Clinic, presented his findings at the 54th annual meeting of the Congress of Neurological Surgeons. Researchers studied patients with medica...Gene for Joubert syndrom with excessive brain folds discovered by UCSD researchers and Harvard team
... Prior to this finding, there was very little that could be offered in terms of genetic evaluation, but the current findings are a step in the right direction, Gleeson said, adding that "although there will ultimately be several more genes identified that can lead to the various forms of Joubert Syndrome, ...Early life stress can inhibit development of brain-cell communication zones, UCI study finds
...endritic growth in hippocampus tissue in which CRH could not exert any effect because the CRH receptor was eliminated via genetic engineering. "Thus, we had two lines of evidence suggesting that too much CRH in the developing hippocampus might lead to the abnormal dendrites," said Baram, a pediatric neurol...For inferring the biological tree of life, simple is better
... often turn out to be hazardous. In many cases, we could prevent damage from these chemicals altogether by using safer alternatives, but these are often overlooked because of government's reliance on risk assessment. Here again, simpler would lead to a better outcome."...... create the right hemisphere dominated brain which could help in science. The extremes of low testosterone and high testosterone for men would create the scientific brain, and the normal range in the middle would create the 'social science' brain, he said. "The question also arises as to why more women, w...