Jan Lwe awarded 2007 EMBO Gold Medal
... to explore the bacterial cytoskeleton using X-ray crystallography and electron microscopy and are starting to use electron tomography of whole, frozen cells to visualise the cytoskeleton in cells. Jan is now determining how bacterial actin and tubulin homologues and other key molecules control chromosome separati...Researchers watch antibiotics, bacteria meet at atomic level
...ng technique called X-ray crystallography. X-ray crystallography let them create a computerized image showing the minute details of the elongation complex. In the second study, the team learned how the antibiotic streptolydigin blocks transcription. Streptolydigin has been around for several decades and the rese...Researchers use new approach to predict protein function
...tal techniques, computational techniques and X-ray crystallography for predicting the function of a protein of previously unknown function, Gerlt said. These methods will speed the task of identifying the biological roles of some of the hundreds of thousands of proteins whose functions have not yet been discovered...Malaria-resistant mosquitoes battle disease with 'molecular warhead'
...e UT Southwestern group used a method called X-ray crystallography to uncover TEP1s three-dimensional structure. They... the 1988 Nobel Prize in chemistry for using X-ray crystallography to describe the structure of a protein involved in photosynthesis. Malaria is one of the leading ...Researchers create model of cancer-preventing enzyme, study how it works
...n, as well as the bacterial version. Using X-ray crystallography and biochemical analysis, the team created a model of proline dehydrogenase that can tell scientists more about the molecules structure and functions. "The three-dimensional model tells us a lot about the structure of the molecules and...Argonne's Joachimiak and Rosenbaum honored with the 2007 Compton Award
...he APS as a premier location worldwide for protein crystallography research. "Andrzej and Gerd were nominated for t... of their individual, key contributions to protein crystallography research at the APS. The award underscores the worldwide stature of protein crystallography conducte...BCM, Rice make major advance in structural biology
...University, one of the founding fathers of protein crystallography in the North America, said, "This recent success in X-ray crystallographic refinement is revolutionary for the field of structure biology in terms of improving large and flexible complex structures that are becoming far more abundant nowadays. It is ...Researchers figure out what makes a simple biological clock tick
...o they could determine their structure using X-ray crystallography repeatedly failed. It wasnt until they began putting the mixture under the transmission electron microscope that they realized the reason for this failure. "It turns out that the complexes do not form one static structure, which is why we could not c...RNA enzyme structure offers a glimpse into the origins of life
...rystals of the ribozyme so that he could use x-ray crystallography to determine its structure. Crystallizing RNA molecules is extremely difficult, and Robertson tried dozens of different versions of the ribozyme under different conditions before he succeeded. Using x-ray crystallography--which involves shining a bea...Study reveals how some molecules inhibit growth of lung cancer cells
...by Michael Eck, MD, PhD, of Dana-Farber used X-ray crystallography to determine the structure of two mutated forms of the epidermal growth factor receptor (EGFR) in lung cancer cells. EGFR, a protein known as a tyrosine kinase, plays a key role in relaying growth signals within cells. When mutated, it can become ove...Chemical switch triggers critical cell activities
...ite with nothing to do and nowhere to go. An X-ray crystallography image could then capture that moment....Study reveals molecular basis of botulism toxin's deadly activity
...process, but the details were unknown. Using x-ray crystallography on type B (there are seven structurally and functi...fellow in the Stevens lab, who conducted the x-ray crystallography work for the study along with Qing Chai, another Scripps Research postdoctoral fellow. "If you block...Botulism study could lead to new vaccines and treatments to counter bioterrorist attacks
... studies, scientists used a technique called X-ray crystallography to produce the first three-dimensional, atomic-sca...omas Binz of the Medical School of Hannover. X-ray crystallography was conducted at SSRL and the Lawrence Berkeley National Laboratory. Research was supported by HHMI,...Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity
...of the polymerase II transcribing complex by X-ray crystallography in 2001. Those structures revealed the complex with a nucleotide still in the enzymes addition site, just after it had been added to the RNA transcript. Later X-ray structures revealed the transcribing complex with the addition site available for en...Learning how nature splits water
...tive combination of x-ray spectroscopy and protein crystallography to yield the highest-resolution structures yet of ...study to combine x-ray absorption spectroscopy and crystallography in such a detailed manner to determine the structure of an active metal site in a protein, especial...Genetic repair mechanism clears the way for sealing DNA breaks
...urce. The researchers used a combination of X-ray crystallography and small angle X-ray scattering (SAXS). They conducted their studies with a model organism called Sulfolobus solfataricus that has many of the same biochemical characteristics of multicelled organisms, including humans. "We expected that DNA ligase...New study shows how genetic repair mechanism helps seal DNA breaks
...h resolution, the team used a combination of x-ray crystallography and small angle x-ray scattering (SAXS) at the SIBYLS beamline at Berkeley Lab's Advanced Light Source. "This paper shows that the SIBYLS beamline is well suited to define dynamic interactions that control cell biology and processes such as cancer,"...Squeeze play: Protein's grip like a baseball bunter's
...om Rice and UT-Houston used a combination of X-ray crystallography and nuclear magnetic resonance (NMR) to determine ...rip in this situation. "The combination of X-ray crystallography and NMR residual dipolar couplings allowed us to identify both the overall structure of the complex ...Burnham awarded $12.7 million from NIH to create one of nation's top neuroscience research centers
... 13 core areas, including: stem cells, proteomics, crystallography and nuclear magnetic imaging work, structural biology, functional genomics, genetic analysis, neurobehavior in mice, diseases of nerve cells, electrophysiology studies of nerve impulse transmission, drug screening, and biostatistics and computational...Biologists probe the machinery of cellular protein factories
...crystals and Korostelev and Laurberg performed the crystallography and solved the structure, Noller said....