Tag: "culture" at biology news
PTEN, TSC2, and tumorigenesis
... upon loss of the TSC genes has been shown in cell culture
experiments to be due to uncontrolled mTOR activity, as the mTOR inhibitor rapamycin can restore Akt activation. Our findings that relieving this feedback mechanism in vivo greatly enhances tumor growth in this mouse model of tuberous sclerosis comp...
New technique rapidly detects illness-causing bacteria
...urce quickly. It may also help to analyze a throat culture
swab, to tell if someone has an illness like strep throat. "We hope to see this technique commercialized, because it is very rapid compared to all the standard methods right now," said Nugen, the study's lead author. Nugen conducted his research in ...
Researchers identify gene's role in suppressing longevity
...sults too broadly, because dividing mouse cells in culture
are an imperfect model of how aging affects human ...an imperfect model for aging, and findings in cell culture
studies are far from directly applicable to effects in whole organisms. Alt and his colleagues are ...
'Achilles' heel' of the herpes virus possibly found
...am members in working with the genomic library and culture
of human and pig cells, especially U-M doctorate graduate Aleida Perez and postdoctoral fellows Qingxue Li and Pilar Perez-Romero. Perez-Romero is first author of one of the two new papers, and a co-author on the other. The two new papers show that ...
RPE meets EPR
...ctly how it happens." He grows human RPE cells in culture
in his lab, but "until now, we have had no direct ...s to boost melanin levels, first in cells grown in culture
and, if that appears promising, in animal models....
Pitt to teach green building in the tropics
...believe that by learning to adapt to the Brazilian culture
and to study, research, and live in Brazil for an extended period, the IGERT fellows will then have the confidence and ability to adjust to other cultures throughout the world," Beckman added. "This will make the graduating fellows highly desirable t...
New factor implicated in allergy and asthma attacks
...e produce damaging reactive oxygen species in cell culture
and, in experiments with mice, in their lungs and airway lining fluid. The resulting oxidative stress, Boldogh said, almost immediately prompted the production of inflammatory immune signaling molecules and accumulation of inflammatory cells, a down...
Discarded placentas deliver researchers promising cells similar to embryonic stem cells
... cells choosing to spread out at the bottom of the culture
dish thereby giving those cells just above them the best environment for replicating and for retaining their stem cell characteristics. With the addition of various growth factors, the authors report the amnion-derived cells could differentiate to be...
Firefly protein lets researchers monitor molecule linked to cancer
...ns are hitting this exact molecular target in cell culture
and laboratory animals," says senior investigator David Piwnica-Worms, M.D., Ph.D., professor of molecular biology and pharmacology and of radiology. Piwnica-Worms and lead author Shimon Gross, Ph.D., a postdoctoral fellow, measured light from the f...
Genetically modified maize not found in southern Mexico
...ountain villages in the region. In a country whose culture
and identity revolve heavily around maize, or corn the crop was first developed here thousands of years ago the thought of importing GM varieties that could contaminate native plants frightens many citizens. "The genetic diversity of native maize i...
Joslin researchers discover new gene for type 2 diabetes using DNA chips
...ducing the level of the ARNT gene in beta cells in culture
also produced defects in glucose-stimulated insulin release and alterations in islet gene expression that mimic those in humans with type 2 diabetes. "This study represents the first use of DNA chips to study islets of diabetic patients and the firs...
Rockefeller researchers show evidence of asymmetric cell division in mammalian skin
...ology at Rockefeller. "Through experiments in cell culture
in the 1980s, everyone believed that the epidermis maintained its protective function by ejecting cells from the basal layer and forcing them upward. Our data show that asymmetric divisions occur perpendicular to the basal layer, resulting in one of ...
TPA and ATRA a potential one-two punch for cancer of the pancreas
...d. "We found that the TPA/ATRA combination in cell culture
worked better than the individual compounds alone." The researchers injected cells from the human cancer cell lines into immunodeficient mice mice specifically bred so that their immune systems would not reject foreign biological material to gr...
Stem cells bring fast direct improvement, without differentiation, in acute renal failure
...vested easily from bone marrow, isolated, grown in culture
and genetically engineered. To test that MSC subsequently used in these studies retained their phenotype after being cultured, the researchers routinely tested whether their characteristic potential to differentiate into fat and bone cells was preser...
Team of international scientists departs today to discover the unknown in China's Himalayan region
.... To further explore new opportunities for linking culture
and environmental protection, Disney will research the legend of the yeti, a creature whose traditional role as "protector of the sacred" has been integral to preservation in this region. One of the world's hotspots, the Mountains of Southwest China...
Cultural norms not unique to human societies
...zee communities in Africa indeed reflect a form of culture
and establishes another link between human and chi... unexpected, but equally important, result of this culture
study, according to Dr. Horner. A few members of each group independently discovered the alternative...
VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease
...the excess of IFNγ. When researchers tried to culture
mast cells from the bone marrow of these mice, the mast cells died. Furthermore, a separate strain of mice with the same mutation as the first strain, but that had also been engineered to prevent IFNγ production, were found to have almost as ma...
NFCR - Prostate Cancer Foundation unite with Burnham Institute to expedite cancer drug discovery
...r Center to develop three-dimensional experimental culture
systems that simulate a tumor's micro-environment....a significant advancement over conventional tissue culture
methods in which cells are grown in two-dimension, as a flattened layer on plastic. The new method ...
First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
...erapeutic antibodies produced by conventional cell culture
methods. The new report was published in the Septe...ns as an alternative to established mammalian cell culture
systems," said Robert J. Etches, Ph.D., D. Sc., Origen Therapeutics vice president, research. "Antib...
Anthrax test, developed by army and CDC, receives FDA approval
.... "Wherever the virus is added to the surface of a culture
plate that has been inoculated with suspicious anthrax colony growth, you can see clear zones where the B. anthracis cells have been destroyed--whereas other bacterial cells grow unaffected." Well before the anthrax attacks of 2001, scientists at USA...
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