After flu exposure, mild exercise protects mature mice from dying
... they'll be studying include: lung histopathology, cytokine gene and protein expression in the lung, and possible development of flu-specific immune cells. At the moment, the laboratory also has a large NIH-funded human clinical trial underway examining whether or not moderate exercise training can improve im...New insight into progression of colorectal cancer
...trating T lymphocytes. Specifically, a form of the cytokine interleukin (IL)-6 was shown to play a key role and inhibition of TGF-b-dependent IL-6 trans-signaling prevented tumor progression. The researchers conclude that development and progression of colorectal cancer is dependent on TGF-b production in tum...Yerkes researchers to present array of new data at Society for Neuroscience Meeting
... by examining, for the first time, the activity of cytokine proteins in the brain that regulate the immune system. They determined, using rats reared differently, those animals that had negative early life experiences had decreased immune system function as adults. (2 pm 3 pm) Jim Herndon, PhD, research pr...JCI table of contents November 1, 2004
...mily members may be primary targets of profibrotic cytokine signaling and that imatinib represents a potentially effective in vivo therapy for growth-dependent fibrosis in an animal model. TITLE: Imatinib mesylate inhibits the profibrogenic activity of TGF-b and prevents bleomycin-mediated lung fibrosis AUTH...First human trial of bioartificial kidney shows promise for acute renal failure
... with toxic waste products, and cannot provide the cytokine regulation function of living cells. Traditional therapy for patients with acute or chronic renal failure involves dialysis or kidney transplant, both of which have limitations. Humes and his colleagues began developing this technology a decade ago, ...A new target for control of obesity
...and is implicated in a variety of growth factor or cytokine pathways present in these cells. The physiological function of Shp2 is largely unknown. Whether it is active in multiple pathways or focused on a single pathway remains to be seen. In recent years, in vitro experiments suggest that Shp2 plays a...Rethinking new therapies for Crohn's disease at U.Va.
...Crohn's, which blocks the production of the type 1 cytokine TNF. He points out that infliximab therapy does not relieve Crohn's symptoms or induce remission in some patients. Plus, type 1 cytokines are important in combating infections, and blocking them can reactivate latent tuberculosis in some patients. ...Rare immunodeficiency provides new insight into immune system function
... information about the regulation of T helper cell cytokine secretion, a process that is absolutely critical f...at T helper cells in these animals exhibit reduced cytokine production. Dr. Pamela L. Schwartzberg from the National Human Genome Research Institute and colleag...Abundance of myostatin in infected swine may result in reduced muscle mass
...ve reduced appetite when they are sick. "The cytokine molecules are the key, because they are the messengers used by the immune system to alter other systems that are relevant to growth," Johnson said. At the suggestion of co-author Jeffery Escobar, a former doctoral student now with the USDA/A...New protein structure may aid in design of therapeutics for autoimmune disease
...uction results in defects in T cell activation and cytokine production." Dr. Somers and his colleagues at Wyeth determined the three-dimensional structure of the catalytic domain of PKCΘ using x-ray crystallography. "This is the first structure of a PKC at atomic resolution," notes Dr. Somers. "More...New findings in innate immunity may lead to treatments for atherosclerosis
... regulates the expression of the anti-inflammatory cytokine IL-10. Because atherosclerosis patients often have...These IRAKs then activate and/or regulate specific cytokine gene expression," explains Dr. Liwu Li of the Wake Forest University School of Medicine. However, th...Racial disparities noted in immune system genes
... race-specific distribution of allelic variants in cytokine genes known to promote inflammation. Chromosomes and genes occur in alternative forms, and these alternative genetic forms are called alleles. Cytokines are proteins that are secreted by immune system cells that regulate the body's immune response to...New signaling step for key player in Crohn's Disease
... to somehow both activate and inhibit inflammatory cytokine responses in the cell. The work is reported by Lewis Cantley and colleagues at Harvard Medical School. Crohn's Disease is an autoimmune inflammatory disorder of the gastrointestinal tract and is histologically characterized by inflammation, epithelia...EB and IUPS - Where cures of tomorrow can be seen in the science of today
...armacology; biomedical engineering; interferon and cytokine research; neuroimmunology, mucosal, and natural immunity, to name a few. Throughout the week, scientists - and reporters covering the meeting - will be able to choose among scientific presentations listed in telephone-book sized programs, searchable...Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
...d remember, possibly via some link (says Bilbo) to cytokine IL-1BETA production....Mouse model of leukemia yields exciting therapeutic implications for rare childhood cancer
...tein Shp2 is required for normal growth factor and cytokine signaling. Mutations in Shp2 cause Noonan Syndrome (NS), which is associated with an increased risk of juvenile myelomonocytic leukemia (JMML), and Shp2 mutations have been associated with sporadic JMML as well as other leukemias. Dr. M. Golam Mohi...Anita Roberts to deliver Excellence in Science lecture
...haracterized, together with Dr. Michael Sporn, the cytokine transforming growth factor- (TGF-). Growth factors are proteins that bind to receptors on cell surfaces to activate cellular proliferation and differentiation. Many growth factors are quite versatile, stimulating cellular division in numerous differ...JCI table of contents April 1, 2005
...ls from XLP patients had reduced production of the cytokine IL-10 and did not effectively stimulate B cell immunoglobulin production. The results identify IL-10 as a key player contributing to impaired humoral immunity in XLP and offer potential therapeutic approaches for the treatment of this immunodeficienc...Cooperation is keya new way of looking at MicroRNA and how it controls gene expression
...ases. For example, the expression of inflammatory cytokine proteins by immune system cells must be finely tuned so that these proteins do not cause more damage to the body than the bacterial infection they were produced to defeat. Excessive inflammation can lead to organ failure and death, and this is exactl......ulations," says Jackman. To determine whether the cytokine levels could be differentiated from a healthy popu...ary based on infectious agent, they hope to create cytokine profiles that will help identify specific diseases. They are also working on redesigning the breath...