Tag: "decoy" at biology news
New target for HIV/AIDS drugs and vaccine discovered
...d arm of our immune system, we can begin to design decoy
proteins or to devise new vaccines. Millions of lives depend on our finding a way to restore both aspects of our immune defense against HIV/AIDSthis study should go a long way toward that goal. ...
New way to target and kill antibiotic-resistant bacteria found
...ds at the same time. The team suspected a chemical decoy
a phosphate ion could plug this dual DNA binding site. Redinbo, who has a background in cancer and other disease-related research, realized that bisphosphonates were the right-size decoy. There are several bisphosphonates on the market; two prov...
Decoy pill saves brain cells
... The researchers injected laboratory mice with a decoy
peptide containing a snippet of a receptor that fa...ped the toxic enzyme calpain would latch on to the decoy
instead of the actual receptor, averting brain damage. As a test, the researchers then injected th...
Homing nanoparticles pack multiple assault on tumors
...rwise been directed toward CREKA-SPIO. The use of decoy
molecules extended the half-life of CREKA-SPIO in circulating blood five-fold, which greatly increased the nanoparticle's ability to home to tumors. The CREKA-SPIO that accumulated in the tumor enhanced blood clotting in tumor vessels, creating add...
Arthritis drug might reduce fatigue in cancer patients
...instead of hindering it. The drug etanercept is a decoy
receptor that blocks interaction with TNF. The researchers hypothesized that the drug might therefore work like a sponge to "soak up" TNF and lower the amount of the substance in the body, which would decrease tumor growth and help reduce fatigue. T...
Einstein researchers find potential new drugs for tuberculosis
...s normal cell-wall-building reaction. Two of these decoy
chemicals, 2-HA and 2-OA, proved much more potent than isoniazid at killing the bacteria--but not in the way the researchers expected. "We were surprised to find that 2-HA and 2-OA were actually being metabolized in mycobacteria into two different ...
Grabbing addiction by the tail
...te receptor and, once inside a neuron, serves as a decoy
to prevent the loss of glutamate receptors. Yu Tian Wang, an HHMI international research scholar, and colleagues at the University of British Columbia in Vancouver report their findings in the November 25, 2005, issue of the journal Science. In add...
JCI table of contents November, 2005
...reated human synovium-SCID mouse chimeras with the decoy
receptor TACI:Fc. Treatment destroyed germinal cen...ne colitis and murine Crohn disease with NF-kappaB decoy
oligodeoxynucleotides. The authors find that blockade of NF-kappaB activity is useful for both majo...
UCLA scientists reveal how Nipah virus infects cells
...th Nipah virus proteins embedded in its coat. The decoy
virus successfully infected cells vulnerable to th...ct Nipah-resistant cells. In the final step, the decoy
virus entered nerve cells and cells lining blood vessels by latching onto Ephrin-B2, proving that th...
New binding target for oncogenic viral protein
...s. Clurman and Welcker suspect that by acting as a decoy
and binding to Fbw7, T antigen protects cellular Fbw7 targets that facilitate viral replication and tumorigenesis. "I think this work underlines the importance of Fbw7 as an emerging tumor suppressor and the consequences of its loss in tumors," Dr. W...
Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
... the effects of excess RANK Ligand. OPG acts as a decoy
receptor, preventing RANK Ligand from binding to its receptor, RANK, on the surface of osteoclasts and osteoclast precursors. By binding to RANK Ligand, OPG prevents the formation and activation of osteoclasts and helps keep the bone loss process in...